IL-2 Signaling Pathway (Homo sapiens)

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Description

IL-2 is a multifunctional cytokine with pleiotropic effects on several cells of the immune system. IL-2 was originally discovered as a T cell growth factor, but it was also found to have actions related to B cell proliferation, and cytolytic activity of natural killer cells. IL-2 also activates lymphokine activated killer cells. In contrast to its proliferative effects, IL-2 also has potent activity in a process known as activation-induced cell death. More recently, IL-2 was shown to promote tolerance through its effects on regulatory T cell development. IL-2 clinically has anti-cancer effects as well as utility in supporting T cell numbers in HIV/AIDS. There are three classes of IL-2 receptors, binding IL-2 with low, intermediate, or high-affinity. The low affinity receptor (IL-2Rα alone) is not functional; signaling by IL-2 involves either the high affinity hetero-trimeric receptor containing IL-2Rα, IL-2Rβ and the common cytokine receptor gamma chain (originally named IL-2Rγ and now generally denoted as γc) or the intermediate affinity heterodimeric receptor composed of IL-2Rβ and γc. IL-2 stimulation induces the activation of the Janus family tyrosine kinases JAK1 and JAK3, which associate with IL-2Rβ and γc, respectively. These kinases in turn phosphorylate IL-2Rβ and induce tyrosine phosphorylation of STATs (signal transducers and activators of transcription) and various other downstream targets. The downstream signaling pathways activated by IL-2 also involves mitogen-activated protein kinase and phosphoinositide 3-kinase signaling modules, leading to both mitogenic and anti-apoptotic signals. Please access this pathway at NetSlim database.

Comments

GenMAPP notes 
NetPath_14 - IL-2 signaling pathway. NetPath (http://www.netpath.org) is a collaborative project between PandeyLab at Johns Hopkins University (http://pandeylab.igm.jhmi.edu) and the Institute of Bioinformatics (http://www.ibioinformatics.org). If you use this pathway, you must cite the NetPath website until the pathway is published.
GenMAPP remarks 
http://www.netpath.org

Ontology Tags

 

Bibliography

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History

View all...
CompareRevisionActionTimeUserComment
72047view16:52, 24 October 2013Mkutmonupdated annotations
70015view01:49, 12 July 2013AlexanderPicoModified title
67369view10:43, 26 June 2013Christine ChichesterOntology Term : 'interleukin-2 signaling pathway' added !
63209view20:57, 8 May 2013MaintBotUpdating gpml version
59182view18:45, 22 February 2013MaintBotUpdated Ensembl data source
48400view07:35, 24 May 2012NetPathModified description
48399view07:30, 24 May 2012NetPathModified description
46125view21:34, 18 December 2011AlexanderPicofixed entrez references
45366view20:58, 7 October 2011AlexanderPicoOntology Term : 'DOID:8406' removed !
45130view00:47, 7 October 2011AlexanderPicofixed db ref
44843view09:45, 6 October 2011MartijnVanIerselOntology Term : 'Interleukin mediated signaling pathway' added !
44833view07:58, 6 October 2011Mkutmonconnected some lines
44622view17:54, 22 September 2011KhanspersUpdating content to NetSlim
44106view20:29, 24 August 2011KhanspersReverted to version '23:39, 1 March 2011' by Khanspers
44029view23:05, 22 August 2011KhanspersModified description
44028view23:03, 22 August 2011KhanspersUpdating pathway from NetSlim
41145view23:39, 1 March 2011MaintBotRemoved redundant pathway information and comments
35641view21:29, 12 February 2010KhanspersModified description
20779view11:29, 14 November 2008MaintBot[[Pathway:Homo sapiens:IL-2 NetPath 14]] moved to [[Pathway:WP49]]: Moved to stable identifier
8164view13:46, 7 January 2008MaintBot[[Pathway:Human:IL-2 NetPath 14]] moved to [[Pathway:Homo sapiens:IL-2 NetPath 14]]: Renaming species
7702view16:10, 18 December 2007MaintBotfixed category names
7241view12:41, 4 November 2007MaintBotAdded categories to GPML
6335view22:17, 22 May 2007A.Pandeygpml file for [[Human:IL-2_NetPath_14]]

External references

View all...
NameTypeDatabase referenceComment
MAPK3Protein5595 (Entrez Gene)
SOS1Protein6654 (Entrez Gene)
STAT3Protein6774 (Entrez Gene)
NMIProtein9111 (Entrez Gene)
STAT1Protein6772 (Entrez Gene)
CISHProtein1154 (Entrez Gene)
MAPK1Protein5594 (Entrez Gene)
RPS6KB2Protein6199 (Entrez Gene)
AKT1Protein207 (Entrez Gene)
STAT5BProtein6777 (Entrez Gene)
CBLProtein867 (Entrez Gene)
MAP2K1Protein5604 (Entrez Gene)
GAB2Protein9846 (Entrez Gene)
GRB2Protein2885 (Entrez Gene)
MAP2K2Protein5605 (Entrez Gene)
PTPN11Protein5781 (Entrez Gene)
SHC1Protein6464 (Entrez Gene)
STAT5AProtein6776 (Entrez Gene)
FYNProtein2534 (Entrez Gene)
PIK3R1Protein5295 (Entrez Gene)
IL2Protein3558 (Entrez Gene)
MTORProtein4137 (Entrez Gene)
CRKLProtein1399 (Entrez Gene)
RAF1Protein5894 (Entrez Gene)
LCKProtein3932 (Entrez Gene)
IL2RBProtein3560 (Entrez Gene)
IL2RGProtein3561 (Entrez Gene)
FOXO3AProtein2309 (Entrez Gene)
RPS6Protein6194 (Entrez Gene)
JAK3Protein3718 (Entrez Gene)
MYCRna4609 (Entrez Gene)
PTK2BProtein2185 (Entrez Gene)
BCL2Rna596 (Entrez Gene)
RPS6KB1Protein6198 (Entrez Gene)
JUNRna3725 (Entrez Gene)
JAK1Protein3716 (Entrez Gene)
CCND2Rna894 (Entrez Gene)
SYKProtein6850 (Entrez Gene)
IL2RAProteinENSG00000134460 (Ensembl)
SOCS3Protein9021 (Entrez Gene)
FOSRna2353 (Entrez Gene)
HRASGeneProductENSG00000174775 (Ensembl)
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