This pathway was created using the GPCRDB (Horn et al., 1998), http://www.gpcr.org/7tm/ (originally at http://www.cmbi.kun.nl/7tm/). The groupings are based on the GPCR phylogenetic tree available from the GPCRDB and the training sets used by Karchin et al. (Bioinformatics, 2002, pg. 147-159). The labels indicate children and grandchildren of the various classes of GPCRs as described by these references.
Horn F, Weare J, Beukers MW, Hörsch S, Bairoch A, Chen W, Edvardsen O, Campagne F, Vriend G; ''GPCRDB: an information system for G protein-coupled receptors.''; Nucleic Acids Res, 1998 PubMed
Karchin R, Karplus K, Haussler D; ''Classifying G-protein coupled receptors with support vector machines.''; Bioinformatics, 2002 PubMed