Statin Pathway (Homo sapiens)

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Curation Tags

Description

Statins inhibit endogenous cholesterol production by competitive inhibition of HMG-CoA reductase (HMGCR), the enzyme that catalyzes conversion of HMG-CoA to mevalonate, an early rate-limiting step in cholesterol synthesis. This pathway delineates genes involved in statin pharmacogenomics, including genes involved in mediating the effects of statins on plasma lipoprotein metabolism.

Sources: PharmGKB and Wikipedia

Ontology Tags

 

Bibliography

  1. Chen H, Ikeda U, Shimpo M, Shimada K; ''Direct effects of statins on cells primarily involved in atherosclerosis.''; Hypertens Res, 2000 PubMed
  2. Wetterau JR, Lin MC, Jamil H; ''Microsomal triglyceride transfer protein.''; Biochim Biophys Acta, 1997 PubMed

History

View all...
CompareRevisionActionTimeUserComment
71273view22:20, 16 October 2013MaintBotAutomated update of data sources
69841view15:36, 11 July 2013EveloOntology Term : 'cardiovascular system disease' added !
68390view20:59, 4 July 2013Mkutmonreplaced interactions in legend with graphical lines
67910view23:17, 27 June 2013AlexanderPicoAdded ref for MTP:PDI complex
64356view05:43, 24 May 2013EgonwAdded missing metabolite identifiers.
59209view19:50, 22 February 2013MaintBotUpdated Ensembl and UniProt data source
45117view23:22, 6 October 2011KhanspersOntology Term : 'hepatocyte' added !
45116view23:20, 6 October 2011KhanspersOntology Term : 'statin drug pathway' added !
45115view23:20, 6 October 2011KhanspersOntology Term : 'CL:0000679' removed !
43561view21:13, 29 June 2011Samuel Sklarmir33 added
41203view23:44, 1 March 2011MaintBotRemoved redundant pathway information and comments
40175view21:38, 14 February 2011AlexanderPicoadded legend
40174view21:34, 14 February 2011AlexanderPicoModified description
39393view02:43, 20 November 2010AlexanderPicoSpecify description
39392view02:35, 20 November 2010AlexanderPicoupdated cells
38114view23:59, 12 August 2010AlexanderPico
38074view04:30, 9 August 2010AlexanderPicoliver cell
38073view04:26, 9 August 2010AlexanderPico
38072view04:25, 9 August 2010AlexanderPicooverhaul
37434view23:17, 2 June 2010NsalomonisSpecify description
35535view14:14, 12 February 2010Thomasadded literature
34460view18:26, 10 December 2009MaintBotAutomatic update of empty xrefs
34038view18:56, 9 December 2009KhanspersPeriodical save, work in progress
34024view18:46, 9 December 2009KhanspersPeriodical save, work in progress
33994view18:36, 9 December 2009KhanspersPeriodical save, work in progress
32094view13:43, 14 August 2009MaintBotFixed group labels
29996view22:27, 23 June 2009NsalomonisModified description
21586view11:32, 14 November 2008MaintBot[[Pathway:Homo sapiens:Statin Pathway PharmGKB]] moved to [[Pathway:WP430]]: Moved to stable identifier
20390view19:54, 3 November 2008AlexanderPico
18816view08:31, 7 September 2008AlexanderPicoModified categories
16871view17:42, 27 June 2008Nsalomonisreduced legend
16869view17:40, 27 June 2008Nsalomonislayout
16867view17:37, 27 June 2008Nsalomonischange
16865view17:30, 27 June 2008Nsalomonismore
16863view17:23, 27 June 2008Nsalomoniscompacted
16861view17:19, 27 June 2008NsalomonisReverted to version '01:43, 18 June 2008' by Nsalomonis
16858view17:19, 27 June 2008NsalomonisReverted to version '01:42, 18 June 2008' by Nsalomonis
16582view19:22, 22 June 2008AlexanderPicoModified categories
16321view01:43, 18 June 2008NsalomonisSpecify description
16319view01:42, 18 June 2008NsalomonisSpecify description
16317view01:39, 18 June 2008Nsalomonisupdated URL for GenMAPP notes
15281view07:25, 27 May 2008Thomasgrouped APO
15016view01:10, 25 May 2008AlexanderPicoConnected!
15014view01:01, 25 May 2008AlexanderPicoFixed metabolites
15012view00:54, 25 May 2008AlexanderPicoPeriodical save, work in progress
13119view11:17, 17 May 2008MaintBotautomated metabolite conversion
11881view18:17, 8 May 2008KhanspersChanged author and contact info
8402view13:46, 7 January 2008MaintBot[[Pathway:Human:Statin Pathway PharmGKB]] moved to [[Pathway:Homo sapiens:Statin Pathway PharmGKB]]: Renaming species
7818view16:20, 18 December 2007MaintBotfixed category names
7395view12:42, 4 November 2007MaintBotAdded categories to GPML

External references

View all...
NameTypeDatabase referenceComment
HDLMetaboliteC01834 (KEGG Compound)
MIR33AGeneProductENSG00000207932 (Ensembl)
CYP7A1GeneProduct1581 (Entrez Gene)
SqualeneMetaboliteHMDB00256 (HMDB)
SOAT1GeneProduct6646 (Entrez Gene)
TriglycerideMetaboliteC00422 (KEGG Compound)
DGAT1GeneProduct8694 (Entrez Gene)
APOA5GeneProduct116519 (Entrez Gene)
LDLRGeneProduct3949 (Entrez Gene)
Acyl-CoA synthetaseProtein84532 (Entrez Gene)
SCARB1GeneProduct949 (Entrez Gene)
Fatty acidMetaboliteC00162 (KEGG Compound)
LRP1GeneProduct4035 (Entrez Gene)
IDLMetaboliteC01834 (KEGG Compound)
LPLGeneProduct4023 (Entrez Gene)
ABCG8GeneProduct64241 (Entrez Gene)
LIPCGeneProduct3990 (Entrez Gene)
DAGMetaboliteC00165 (KEGG Compound)
CETPGeneProduct1071 (Entrez Gene)
SQLEGeneProduct6713 (Entrez Gene)
LCATGeneProduct3931 (Entrez Gene)
APOA2GeneProduct336 (Entrez Gene)
ABCA1GeneProduct19 (Entrez Gene)
HMGCRGeneProduct3156 (Entrez Gene)
APOA1GeneProduct335 (Entrez Gene)
PhospholipidMetaboliteC00865 (KEGG Compound)
APOA4GeneProduct337 (Entrez Gene)
LDLMetaboliteC01834 (KEGG Compound)
APOC1GeneProduct341 (Entrez Gene)
VLDLMetaboliteC01834 (KEGG Compound)
APOEGeneProduct348 (Entrez Gene)
ABCG5GeneProduct64240 (Entrez Gene)
APOC2GeneProduct344 (Entrez Gene)
APOBGeneProduct338 (Entrez Gene)
APOC3GeneProduct345 (Entrez Gene)
MTTPProtein4547 (Entrez Gene)
PLTPGeneProduct5360 (Entrez Gene)
MevalonateMetaboliteCHEBI:25350 (ChEBI)
CholesterolMetabolite57-88-5 (CAS)
FDFT1GeneProduct2222 (Entrez Gene)
Cholic AcidMetabolite81-25-4 (CAS)
Acyl-CoAMetaboliteHMDB03419 (HMDB)
Acetyl-CoAMetaboliteHMDB01206 (HMDB)
PDIA2Protein64714 (Entrez Gene)
StatinMetaboliteCHEBI:35664 (ChEBI)
LipoproteinsMetaboliteCHEBI:6495 (ChEBI)
Cholesterol esterMetaboliteC02530 (KEGG Compound)
MIR33BGeneProductENSG00000207839 (Ensembl)
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