Thick Ascending Limb Transporters (Rattus norvegicus)

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This pathway shows the main transporters in the thick ascending limb of the Loop of Henle

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Ontology Terms



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  1. Cabral PD, Herrera M; ''Membrane-associated aquaporin-1 facilitates osmotically driven water flux across the basolateral membrane of the thick ascending limb.''; Am J Physiol Renal Physiol, 2012 PubMed
  2. FĂ©raille E, Doucet A; ''Sodium-potassium-adenosinetriphosphatase-dependent sodium transport in the kidney: hormonal control.''; Physiol Rev, 2001 PubMed
  3. Lee JW, Chou CL, Knepper MA; ''Deep Sequencing in Microdissected Renal Tubules Identifies Nephron Segment-Specific Transcriptomes.''; J Am Soc Nephrol, 2015 PubMed
  4. Hebert SC, Andreoli TE; ''Control of NaCl transport in the thick ascending limb.''; Am J Physiol, 1984 PubMed
  5. Greger R; ''Ion transport mechanisms in thick ascending limb of Henle's loop of mammalian nephron.''; Physiol Rev, 1985 PubMed
  6. Mount DB; ''Thick ascending limb of the loop of Henle.''; Clin J Am Soc Nephrol, 2014 PubMed


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91330view18:17, 2 February 2017Khanspersconnected interactions
89594view15:56, 19 September 2016AgustinGVOntology Term : 'kidney loop of henle thick ascending limb epithelial cell' added !
89125view19:21, 22 August 2016KhanspersModified title
89122view19:17, 22 August 2016KhanspersReverted to version '19:22, 18 August 2016' by Khanspers
89121view19:17, 22 August 2016KhanspersModified title
89037view19:22, 18 August 2016AlexanderPicoConverted interactions to graphical lines to avoid constraints and validation triggers
89036view19:13, 18 August 2016AgustinGVRefs.
89032view19:03, 18 August 2016MaintBotOntology Term : 'regulatory pathway' added !
89031view19:03, 18 August 2016MaintBotOntology Term : 'transport pathway' added !
89030view19:00, 18 August 2016AgustinGVSpecify description
89029view18:59, 18 August 2016AgustinGVSpecify description
89027view18:48, 18 August 2016AgustinGV
89026view18:40, 18 August 2016AgustinGV
89025view18:35, 18 August 2016AgustinGVUpdate CAs
89024view18:20, 18 August 2016AgustinGVModified description
89023view18:19, 18 August 2016AgustinGVOntology Term : 'transporting cell' added !
89022view18:17, 18 August 2016AgustinGVOntology Term : 'kidney epithelial cell' added !
89021view18:16, 18 August 2016AgustinGVMinor alignment
89020view18:14, 18 August 2016AgustinGVNew pathway

External references


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NameTypeDatabase referenceComment
2 ClMetaboliteHMDB00492 (HMDB)
2 KMetaboliteHMDB00586 (HMDB)
3 NaMetaboliteHMDB00588 (HMDB)
ADPMetaboliteHMDB01341 (HMDB)
ATP1A1GeneProduct24211 (Entrez Gene)
ATP1B1GeneProduct25650 (Entrez Gene)
ATPMetaboliteHMDB00538 (HMDB)
Aquaporin 1GeneProduct25240 (Entrez Gene)
BarttinGeneProduct79430 (Entrez Gene)
CA2GeneProduct54231 (Entrez Gene)
CA4GeneProduct29242 (Entrez Gene)
CLC-K2GeneProduct79430 (Entrez Gene)
CO2MetaboliteHMDB01967 (HMDB)
ClMetaboliteHMDB00492 (HMDB)
H2OMetaboliteHMDB02111 (HMDB)
HCO3MetaboliteHMDB00595 (HMDB)
HMetaboliteHMDB59597 (HMDB)
KCC4GeneProduct308069 (Entrez Gene)
KMetaboliteHMDB00586 (HMDB)
NBCn1GeneProduct117955 (Entrez Gene)
NHE3GeneProduct24784 (Entrez Gene)
NKCC2GeneProduct25065 (Entrez Gene)
NaMetaboliteHMDB00588 (HMDB)
ROMKGeneProduct24521 (Entrez Gene)

Annotated Interactions

No annotated interactions

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