MAPK Signaling Pathway (Homo sapiens)

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Description

The mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals express at least four distinctly regulated groups of MAPKs, extracellular signal-related kinases (ERK)-1/2, Jun amino-terminal kinases (JNK1/2/3), p38 proteins (p38alpha/beta/gamma/delta) and ERK5, that are activated by specific MAPKKs: MEK1/2 for ERK1/2, MKK3/6 for the p38, MKK4/7 (JNKK1/2) for the JNKs, and MEK5 for ERK5. Each MAPKK, however, can be activated by more than one MAPKKK, increasing the complexity and diversity of MAPK signalling. Presumably each MAPKKK confers responsiveness to distinct stimuli. For example, activation of ERK1/2 by growth factors depends on the MAPKKK c-Raf, but other MAPKKKs may activate ERK1/2 in response to pro-inflammatory stimuli. Source: KEGG http://www.genome.jp/dbget-bin/www_bget?pathway:map04010

Comments

GenMAPP remarks 
Converted to human by GenMAPP.org

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Bibliography

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  1. Tanoue T, Nishida E; ''Docking interactions in the mitogen-activated protein kinase cascades.''; Pharmacol Ther, 2002 PubMed
  2. Chen Z, Gibson TB, Robinson F, Silvestro L, Pearson G, Xu B, Wright A, Vanderbilt C, Cobb MH; ''MAP kinases.''; Chem Rev, 2001 PubMed
  3. Chen CY, Weng YH, Chien KY, Lin KJ, Yeh TH, Cheng YP, Lu CS, Wang HL; ''(G2019S) LRRK2 activates MKK4-JNK pathway and causes degeneration of SN dopaminergic neurons in a transgenic mouse model of PD.''; Cell Death Differ, 2012 PubMed
  4. Huang EJ, Reichardt LF; ''Trk receptors: roles in neuronal signal transduction.''; Annu Rev Biochem, 2003 PubMed
  5. Yang SH, Sharrocks AD, Whitmarsh AJ; ''Transcriptional regulation by the MAP kinase signaling cascades.''; Gene, 2003 PubMed
  6. Cho H, Lee J, Kwak NJ, Lee KH, Rha S, Kim YH, Cho YY, Yang KH, Kim K, Lim Y; ''Silica induces nuclear factor-kappaB activation through TAK1 and NIK in Rat2 cell line.''; Toxicol Lett, 2003 PubMed
  7. Harper SJ, LoGrasso P; ''Signalling for survival and death in neurones: the role of stress-activated kinases, JNK and p38.''; Cell Signal, 2001 PubMed
  8. Takeda K, Ichijo H; ''Neuronal p38 MAPK signalling: an emerging regulator of cell fate and function in the nervous system.''; Genes Cells, 2002 PubMed
  9. Abell AN, Granger DA, Johnson GL; ''MEKK4 stimulation of p38 and JNK activity is negatively regulated by GSK3beta.''; J Biol Chem, 2007 PubMed
  10. Dent P, Yacoub A, Fisher PB, Hagan MP, Grant S; ''MAPK pathways in radiation responses.''; Oncogene, 2003 PubMed
  11. Zhu X, Lee HG, Raina AK, Perry G, Smith MA; ''The role of mitogen-activated protein kinase pathways in Alzheimer's disease.''; Neurosignals, 2002 PubMed

History

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CompareRevisionActionTimeUserComment
72103view21:47, 24 October 2013Mkutmonadded datasource for "Wnt signaling pathway", "Apoptosis" and "Cell cycle"
70631view00:25, 20 August 2013MaintBotUpdated xrefs by Anatoly Urisman
70021view01:51, 12 July 2013AlexanderPicoModified title
68899view17:29, 8 July 2013MaintBotUpdated to 2013 gpml schema
67443view11:02, 26 June 2013DdiglesOntology Term : 'mitogen activated protein kinase signaling pathway' added !
54211view22:33, 23 November 2012AlexanderPicoAdded Vemurafenib
54210view22:29, 23 November 2012AlexanderPicoAdded lrrk2
44890view10:14, 6 October 2011MartijnVanIerselOntology Term : 'MAPK signaling pathway' added !
41048view23:16, 1 March 2011MaintBotRemoved redundant pathway information and comments
38878view18:52, 24 September 2010KhanspersAdded pathway links and changed line types
38877view18:44, 24 September 2010Khanspers
37347view17:34, 28 May 2010KhanspersConnectors
35657view22:02, 12 February 2010KhanspersLit Refs
35656view22:01, 12 February 2010KhanspersLiterature references
35655view21:59, 12 February 2010KhanspersLiterature references
35654view21:49, 12 February 2010KhanspersModified description
32414view17:06, 15 August 2009MaintBotFixed text labels
32071view13:36, 14 August 2009MaintBotFixed group labels
28779view12:49, 6 March 2009BingoGADD45A-MAP3K4 literature link
21482view11:31, 14 November 2008MaintBot[[Pathway:Homo sapiens:MAPK signaling pathway KEGG]] moved to [[Pathway:WP382]]: Moved to stable identifier
15384view21:59, 27 May 2008KhanspersAdded link to pathway
15380view21:35, 27 May 2008Khanspersadded connectors and changed labels
15378view21:34, 27 May 2008KhanspersPeriodical save, work in progress
15375view21:14, 27 May 2008KhanspersPeriodical save, work in progress
15373view21:04, 27 May 2008KhanspersPeriodical save, work in progress
15370view21:00, 27 May 2008Khanspersadded connectors
15367view19:56, 27 May 2008Khanspersadded connectors
15365view19:52, 27 May 2008KhanspersPeriodical save, work in progress
15363view19:42, 27 May 2008KhanspersPeriodical save, work in progress
12944view10:43, 17 May 2008MaintBotSticky edges patch by Sjoerd
8248view13:46, 7 January 2008MaintBot[[Pathway:Human:MAPK signaling pathway KEGG]] moved to [[Pathway:Homo sapiens:MAPK signaling pathway KEGG]]: Renaming species
7744view16:14, 18 December 2007MaintBotfixed category names
7277view12:41, 4 November 2007MaintBotAdded categories to GPML
6350view22:18, 22 May 2007S.Burelgpml file for [[Human:MAPK_signaling_pathway_KEGG]]

External references

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NameTypeDatabase referenceComment
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MKNK1GeneProduct8569 (Entrez Gene)
PRKCDGeneProduct5580 (Entrez Gene)
MAP3K7GeneProduct6885 (Entrez Gene)
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IL1AGeneProduct3552 (Entrez Gene)
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PPP3R2GeneProduct5535 (Entrez Gene)
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MAPK8IP3GeneProduct23162 (Entrez Gene)
PPM1BGeneProduct5495 (Entrez Gene)
MAPK9GeneProduct5601 (Entrez Gene)
MAP2K5GeneProduct5607 (Entrez Gene)
PAK1GeneProduct5058 (Entrez Gene)
MAPK7GeneProduct5598 (Entrez Gene)
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p53 signaling pathwayPathway
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MAP3K14GeneProduct9020 (Entrez Gene)
IL1BGeneProduct3553 (Entrez Gene)
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cAMPMetaboliteHMDB00058 (HMDB)
IKBKBGeneProduct3551 (Entrez Gene)
Wnt signaling pathwayPathwayWP428 (WikiPathways)
DUSP1GeneProduct1843 (Entrez Gene)
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DUSP6GeneProduct1848 (Entrez Gene)
LRRK2-mutGeneProduct120892 (Entrez Gene)
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BRAF V600EGeneProduct673 (Entrez Gene)
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