Focal Adhesion (Homo sapiens)

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Description

Cell-matrix adhesions play essential roles in important biological processes including cell motility, cell proliferation, cell differentiation, regulation of gene expression and cell survival. At the cell-extracellular matrix contact points, specialized structures are formed and termed focal adhesions, where bundles of actin filaments are anchored to transmembrane receptors of the integrin family through a multi-molecular complex of junctional plaque proteins. Some of the constituents of focal adhesions participate in the structural link between membrane receptors and the actin cytoskeleton, while others are signalling molecules, including different protein kinases and phosphatases, their substrates, and various adapter proteins. Integrin signaling is dependent upon the non-receptor tyrosine kinase activities of the FAK and src proteins as well as the adaptor protein functions of FAK, src and Shc to initiate downstream signaling events. These signalling events culminate in reorganization of the actin cytoskeleton; a prerequisite for changes in cell shape and motility, and gene expression. Similar morphological alterations and modulation of gene expression are initiated by the binding of growth factors to their respective receptors, emphasizing the considerable crosstalk between adhesion- and growth factor-mediated signalling. Source: KEGG http://www.genome.jp/kegg/pathway/hsa/hsa04510.html

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Bibliography

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History

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CompareRevisionActionTimeUserComment
71714view20:06, 17 October 2013MaintBotremoved data source from nodes without identifier
69965view21:06, 11 July 2013MaintBotupdating to 2013 schema
45270view18:49, 7 October 2011AlexanderPico
45269view18:49, 7 October 2011AlexanderPicoOntology Term : 'cell adhesion signaling pathway' added !
41071view23:19, 1 March 2011MaintBotRemoved redundant pathway information and comments
35287view22:50, 11 February 2010KhanspersAdded lit refs
35280view22:39, 11 February 2010KhanspersLit refs
35272view20:40, 11 February 2010KhanspersModified description
32638view14:51, 21 August 2009MaintBotautoconversion of Entrez symbols to IDs
32393view16:59, 15 August 2009MaintBotFixed text labels
32041view13:29, 14 August 2009MaintBotFixed group labels
21323view11:31, 14 November 2008MaintBot[[Pathway:Homo sapiens:Focal adhesion KEGG]] moved to [[Pathway:WP306]]: Moved to stable identifier
13963view11:11, 20 May 2008Thomasadded connectors / groups
13899view14:12, 19 May 2008ThomasWIP on connectors
13897view13:53, 19 May 2008ThomasWIP on connectors
13895view13:37, 19 May 2008ThomasPeriodical save, work in progress
13012view11:05, 17 May 2008MaintBotSticky edges patch by Sjoerd
8058view13:46, 7 January 2008MaintBot[[Pathway:Human:Focal adhesion KEGG]] moved to [[Pathway:Homo sapiens:Focal adhesion KEGG]]: Renaming species
7651view16:07, 18 December 2007MaintBotfixed category names
7222view12:41, 4 November 2007MaintBotAdded categories to GPML
6319view22:17, 22 May 2007169.230.77.174gpml file for [[Human:Focal_adhesion_KEGG]]

External references

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NameTypeDatabase referenceComment
TLN1GeneProduct7094 (Entrez Gene)
TNCGeneProduct3371 (Entrez Gene)
PIP3GeneProduct829662 (Entrez Gene)
TNRGeneProduct7143 (Entrez Gene)
PAK1GeneProduct5058 (Entrez Gene)
VTNGeneProduct7448 (Entrez Gene)
MAPK4GeneProduct5596 (Entrez Gene) MAPK4; mitogen-activated protein kinase 4 [EC:2.7.1.-]
VWFGeneProduct7450 (Entrez Gene)
ACTBGeneProduct60 (Entrez Gene)
LAMC1GeneProduct3915 (Entrez Gene)
BADGeneProduct572 (Entrez Gene)
LAMC3GeneProduct10319 (Entrez Gene)
TXKGeneProduct7294 (Entrez Gene)
TNNGeneProduct63923 (Entrez Gene)
MAP2K2GeneProduct5605 (Entrez Gene) MAP2K2; mitogen-activated protein kinase kinase 2 [EC:2.7.1.-]
COL5A3GeneProduct50509 (Entrez Gene)
AKT3GeneProduct10000 (Entrez Gene)
TNXBGeneProduct7148 (Entrez Gene)
PIK3R5GeneProduct23533 (Entrez Gene)
COL4A6GeneProduct1288 (Entrez Gene)
PDGFDGeneProduct80310 (Entrez Gene)
EGFGeneProduct1950 (Entrez Gene)
CCND1GeneProduct595 (Entrez Gene)
FIGFGeneProduct2277 (Entrez Gene)
PDGFRAGeneProduct5156 (Entrez Gene)
HGFGeneProduct3082 (Entrez Gene)
TNK1GeneProduct8711 (Entrez Gene)
IGF1GeneProduct3479 (Entrez Gene)
MAP2K6GeneProduct5608 (Entrez Gene) MAP2K6; mitogen-activated protein kinase kinase 6 [EC:2.7.1.-
PDGFAGeneProduct5154 (Entrez Gene)
ARHGAP5GeneProduct394 (Entrez Gene)
PDGFBGeneProduct5155 (Entrez Gene)
PDPK1GeneProduct5170 (Entrez Gene)
PGFGeneProduct5228 (Entrez Gene)
PPP1R12AGeneProduct4659 (Entrez Gene)
PELOGeneProduct53918 (Entrez Gene)
PIK3CDGeneProduct5293 (Entrez Gene)
ITGA2GeneProduct3673 (Entrez Gene)
VAV1GeneProduct7409 (Entrez Gene)
ITGA3GeneProduct3675 (Entrez Gene)
PAK7GeneProduct57144 (Entrez Gene)
ITGA4GeneProduct3676 (Entrez Gene)
BCAR1GeneProduct9564 (Entrez Gene)
ITGA5GeneProduct3678 (Entrez Gene)
BIRC4GeneProductBirc4 (Entrez Gene)
ITGA6GeneProduct3655 (Entrez Gene)
Ha-RasGeneProduct
ITGA7GeneProduct3679 (Entrez Gene)
KDRGeneProduct3791 (Entrez Gene)
ITGA8GeneProduct8516 (Entrez Gene)
PTK6GeneProduct5753 (Entrez Gene)
ITGA9GeneProduct3680 (Entrez Gene)
STYK1GeneProduct55359 (Entrez Gene)
ITGA10GeneProduct8515 (Entrez Gene)
BRAFGeneProduct673 (Entrez Gene)
ITGA11GeneProduct22801 (Entrez Gene)
SEPP1GeneProductSepp1 (Entrez Gene) SEPP1; selenoprotein P plasma
ITGA2BGeneProduct3674 (Entrez Gene)
MAPK1GeneProduct5594 (Entrez Gene) MAPK1; mitogen-activated protein kinase 1 [EC:2.7.1.-]
ITGAEGeneProduct3682 (Entrez Gene)
MAP2K1GeneProduct5604 (Entrez Gene) MAP2K1; mitogen-activated protein kinase kinase 1 [EC:2.7.1.-]
ITGADGeneProduct3681 (Entrez Gene)
FARP2GeneProduct9855 (Entrez Gene)
ITGALGeneProduct3683 (Entrez Gene)
CAPN1GeneProduct823 (Entrez Gene)
ITGAMGeneProduct3684 (Entrez Gene)
AKT1GeneProduct207 (Entrez Gene)
ITGAVGeneProduct3685 (Entrez Gene)
ROCK2GeneProduct9475 (Entrez Gene)
ITGAXGeneProduct3687 (Entrez Gene)
MYLKGeneProduct4638 (Entrez Gene)
ITGB1GeneProduct3688 (Entrez Gene)
GSK3BGeneProduct2932 (Entrez Gene)
ITGB2GeneProduct3689 (Entrez Gene)
PIK3R2GeneProduct5296 (Entrez Gene)
ITGB3GeneProduct3690 (Entrez Gene)
PIK3CBGeneProduct5291 (Entrez Gene)
ITGB4GeneProduct3691 (Entrez Gene)
RAC2GeneProduct5880 (Entrez Gene)
ITGB5GeneProduct3693 (Entrez Gene)
PAK2GeneProduct5062 (Entrez Gene)
ITGB6GeneProduct3694 (Entrez Gene)
ELK1GeneProduct2002 (Entrez Gene)
ITGB8GeneProduct3696 (Entrez Gene)
VEGFBGeneProduct7423 (Entrez Gene)
RAP1AGeneProduct5906 (Entrez Gene) RAP1A; RAP1A member of RAS oncogene family
RAPGEF1GeneProduct2889 (Entrez Gene)
RAP1BGeneProduct5908 (Entrez Gene) RAP1B; RAP1B member of RAS oncogene family
BIRC2GeneProduct329 (Entrez Gene)
DOCK1GeneProduct1793 (Entrez Gene) DOCK1; dedicator of cyto-kinesis
MAPK9GeneProduct5601 (Entrez Gene)
SHC1GeneProduct6464 (Entrez Gene) SHC1; SHC (Src homology 2 domain containing) transforming protein 1
CCND3GeneProduct896 (Entrez Gene)
SHC3GeneProduct53358 (Entrez Gene) SHC3; neuronal Sh
Diap1GeneProduct
SOS1GeneProduct6654 (Entrez Gene) SOS1; son of sevenless homolog 1 (Drosophila)
THBS4GeneProduct7060 (Entrez Gene)
ZYXGeneProduct7791 (Entrez Gene) ZYX; zyxin
METGeneProduct4233 (Entrez Gene)
CAV1GeneProduct857 (Entrez Gene) CAV1; caveolin 1 caveolae protein 22kD
PDGFRBGeneProduct5159 (Entrez Gene)
CAV3GeneProduct859 (Entrez Gene) CAV3; caveolin 3
SRMSGeneProduct6725 (Entrez Gene)
FYNGeneProduct2534 (Entrez Gene) FYN; FYN oncogene related to SRC FGR YES [EC:2.7.1.112]
TESK2GeneProduct10420 (Entrez Gene)
GRB2GeneProduct2885 (Entrez Gene) GRB2; growth factor receptor-bound protein 2
TNK2GeneProduct10188 (Entrez Gene)
VASPGeneProduct7408 (Entrez Gene) VASP; vasodilator-stimulated phosphoprotein
ARAFGeneProduct369 (Entrez Gene) ARAF1; v-raf murine sarcoma 3611 viral oncogene homolog 1 [EC:2.7.1.-]
SRCGeneProduct6714 (Entrez Gene) SRC; v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian) [EC:2.7.1.112]
RAF1GeneProduct5894 (Entrez Gene) RAF1; v-raf-1 murine leukemia viral oncogene homolog 1 [EC:2.7.1.-]
ILKGeneProduct3611 (Entrez Gene) ILK; integrin-linked kinase [EC:2.7.1.-]
MAPK7GeneProduct5598 (Entrez Gene) MAPK7; mitogen-activated protein kinase 7 [EC:2.7.1.-
CAV2GeneProduct858 (Entrez Gene) CAV2; caveolin 2
MAP2K5GeneProduct5607 (Entrez Gene) MAP2K5; mitogen-activated protein kinase kinase 5 [EC:2.7.1.-]
ACTN1GeneProduct87 (Entrez Gene)
MAPK12GeneProduct6300 (Entrez Gene) MAPK12; mitogen-activated protein kinase 12 [EC:2.7.1.-]
VCLGeneProduct7414 (Entrez Gene) VCL; vinculin
MAPK6GeneProduct5597 (Entrez Gene) MAPK6; mitogen-activated protein kinase 6 [EC:2.7.1.-]
CHADGeneProduct1101 (Entrez Gene)
MAP2K3GeneProduct5606 (Entrez Gene) MAP2K3; mitogen-activated protein kinase kinase 3 [EC:2.7.1.-]
COL11A1GeneProduct1301 (Entrez Gene)
PTK2GeneProduct5747 (Entrez Gene) PTK2; PTK2 protein tyrosine kinase 2 [EC:2.7.1.112
COL11A2GeneProduct1302 (Entrez Gene)
RHOBGeneProduct388 (Entrez Gene)
COL2A1GeneProduct1280 (Entrez Gene)
FLNAGeneProduct2316 (Entrez Gene)
COL3A1GeneProduct1281 (Entrez Gene)
PXNGeneProduct5829 (Entrez Gene)
COL4A1GeneProduct1282 (Entrez Gene)
RHOAGeneProduct387 (Entrez Gene)
COL4A2GeneProduct1284 (Entrez Gene)
PARVBGeneProduct29780 (Entrez Gene)
COL4A4GeneProduct1286 (Entrez Gene)
AKT2GeneProduct208 (Entrez Gene)
COL5A1GeneProduct1289 (Entrez Gene)
ROCK1GeneProduct6093 (Entrez Gene)
COL5A2GeneProduct1290 (Entrez Gene)
PIP5K1CGeneProduct23396 (Entrez Gene)
COL6A2GeneProduct1292 (Entrez Gene)
MYL6GeneProduct4637 (Entrez Gene)
COL1A1GeneProduct1277 (Entrez Gene)
MYLK2GeneProduct85366 (Entrez Gene)
COL1A2GeneProduct1278 (Entrez Gene)
ACTG1GeneProduct71 (Entrez Gene)
COMPGeneProduct1311 (Entrez Gene)
PIK3CAGeneProduct5290 (Entrez Gene)
FN1GeneProduct2335 (Entrez Gene)
PIK3R1GeneProduct5295 (Entrez Gene)
IBSPGeneProduct3381 (Entrez Gene)
PIK3CGGeneProduct5294 (Entrez Gene)
LAMA2GeneProduct3908 (Entrez Gene)
PIK3R4GeneProduct30849 (Entrez Gene)
LAMA3GeneProduct3909 (Entrez Gene)
PTENGeneProduct5728 (Entrez Gene)
LAMA4GeneProduct3910 (Entrez Gene)
RAC1GeneProduct5879 (Entrez Gene)
LAMA5GeneProduct3911 (Entrez Gene)
RAC3GeneProduct5881 (Entrez Gene)
LAMB1GeneProduct3912 (Entrez Gene)
PAK3GeneProduct5063 (Entrez Gene)
LAMB2GeneProduct3913 (Entrez Gene)
PAK4GeneProduct10298 (Entrez Gene)
LAMC2GeneProduct3918 (Entrez Gene)
PAK6GeneProduct56924 (Entrez Gene)
RELNGeneProduct5649 (Entrez Gene)
PDGFCGeneProduct56034 (Entrez Gene)
SPP1GeneProduct6696 (Entrez Gene)
VEGFGeneProductVEGF (Entrez Gene)
THBS1GeneProduct7057 (Entrez Gene)
VEGFCGeneProduct7424 (Entrez Gene)
THBS2GeneProduct7058 (Entrez Gene)
CRKGeneProduct1398 (Entrez Gene)
THBS3GeneProduct7059 (Entrez Gene)
CDC42GeneProduct998 (Entrez Gene)
LAMB3GeneProduct3914 (Entrez Gene)
BCL2GeneProduct596 (Entrez Gene)
LAMA1GeneProduct284217 (Entrez Gene)
BIRC3GeneProduct330 (Entrez Gene)
BLKGeneProduct640 (Entrez Gene)
MAPK8GeneProduct5599 (Entrez Gene)
EGFRGeneProduct1956 (Entrez Gene)
JUNGeneProduct3725 (Entrez Gene)
ERBB2GeneProduct2064 (Entrez Gene)
CCND2GeneProduct894 (Entrez Gene)
FGRGeneProduct2268 (Entrez Gene)
ITGB7GeneProduct3695 (Entrez Gene)
FLT1GeneProduct2321 (Entrez Gene)
CatnbGeneProduct
HCKGeneProduct3055 (Entrez Gene)
Crk1GeneProduct
IGF1RGeneProduct3480 (Entrez Gene)
PIP2GeneProduct
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