Focal Adhesion (Homo sapiens)

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Cell-matrix adhesions play essential roles in important biological processes including cell motility, cell proliferation, cell differentiation, regulation of gene expression and cell survival. At the cell-extracellular matrix contact points, specialized structures are formed and termed focal adhesions, where bundles of actin filaments are anchored to transmembrane receptors of the integrin family through a multi-molecular complex of junctional plaque proteins. Some of the constituents of focal adhesions participate in the structural link between membrane receptors and the actin cytoskeleton, while others are signalling molecules, including different protein kinases and phosphatases, their substrates, and various adapter proteins. Integrin signaling is dependent upon the non-receptor tyrosine kinase activities of the FAK and src proteins as well as the adaptor protein functions of FAK, src and Shc to initiate downstream signaling events. These signalling events culminate in reorganization of the actin cytoskeleton; a prerequisite for changes in cell shape and motility, and gene expression. Similar morphological alterations and modulation of gene expression are initiated by the binding of growth factors to their respective receptors, emphasizing the considerable crosstalk between adhesion- and growth factor-mediated signalling. Source: KEGG

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  1. Oloumi A, McPhee T, Dedhar S; ''Regulation of E-cadherin expression and beta-catenin/Tcf transcriptional activity by the integrin-linked kinase.''; Biochim Biophys Acta, 2004 PubMed
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  3. Danen EH, Yamada KM; ''Fibronectin, integrins, and growth control.''; J Cell Physiol, 2001 PubMed
  4. Schlaepfer DD, Mitra SK; ''Multiple connections link FAK to cell motility and invasion.''; Curr Opin Genet Dev, 2004 PubMed
  5. Comoglio PM, Boccaccio C, Trusolino L; ''Interactions between growth factor receptors and adhesion molecules: breaking the rules.''; Curr Opin Cell Biol, 2003 PubMed
  6. Guo W, Giancotti FG; ''Integrin signalling during tumour progression.''; Nat Rev Mol Cell Biol, 2004 PubMed
  7. Vanhaesebroeck B, Alessi DR; ''The PI3K-PDK1 connection: more than just a road to PKB.''; Biochem J, 2000 PubMed
  8. Schmitz AA, Govek EE, Böttner B, Van Aelst L; ''Rho GTPases: signaling, migration, and invasion.''; Exp Cell Res, 2000 PubMed
  9. Nicholson KM, Anderson NG; ''The protein kinase B/Akt signalling pathway in human malignancy.''; Cell Signal, 2002 PubMed
  10. Hlobilková A, Knillová J, Bártek J, Lukás J, Kolár Z; ''The mechanism of action of the tumour suppressor gene PTEN.''; Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub, 2003 PubMed
  11. Mitra SK, Hanson DA, Schlaepfer DD; ''Focal adhesion kinase: in command and control of cell motility.''; Nat Rev Mol Cell Biol, 2005 PubMed
  12. Burridge K, Wennerberg K; ''Rho and Rac take center stage.''; Cell, 2004 PubMed
  13. Turner CE; ''Paxillin and focal adhesion signalling.''; Nat Cell Biol, 2000 PubMed
  14. Berman AE, Kozlova NI, Morozevich GE; ''Integrins: structure and signaling.''; Biochemistry (Mosc), 2003 PubMed
  15. Lee JW, Juliano R; ''Mitogenic signal transduction by integrin- and growth factor receptor-mediated pathways.''; Mol Cells, 2004 PubMed
  16. Parsons JT; ''Focal adhesion kinase: the first ten years.''; J Cell Sci, 2003 PubMed
  17. Stupack DG, Cheresh DA; ''Get a ligand, get a life: integrins, signaling and cell survival.''; J Cell Sci, 2002 PubMed


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78800view18:41, 30 January 2015EgonwFixed an Entrez identifier: BIRC4 = 331.
71714view20:06, 17 October 2013MaintBotremoved data source from nodes without identifier
69965view21:06, 11 July 2013MaintBotupdating to 2013 schema
45270view18:49, 7 October 2011AlexanderPico
45269view18:49, 7 October 2011AlexanderPicoOntology Term : 'cell adhesion signaling pathway' added !
41071view23:19, 1 March 2011MaintBotRemoved redundant pathway information and comments
35287view22:50, 11 February 2010KhanspersAdded lit refs
35280view22:39, 11 February 2010KhanspersLit refs
35272view20:40, 11 February 2010KhanspersModified description
32638view14:51, 21 August 2009MaintBotautoconversion of Entrez symbols to IDs
32393view16:59, 15 August 2009MaintBotFixed text labels
32041view13:29, 14 August 2009MaintBotFixed group labels
21323view11:31, 14 November 2008MaintBot[[Pathway:Homo sapiens:Focal adhesion KEGG]] moved to [[Pathway:WP306]]: Moved to stable identifier
13963view11:11, 20 May 2008Thomasadded connectors / groups
13899view14:12, 19 May 2008ThomasWIP on connectors
13897view13:53, 19 May 2008ThomasWIP on connectors
13895view13:37, 19 May 2008ThomasPeriodical save, work in progress
13012view11:05, 17 May 2008MaintBotSticky edges patch by Sjoerd
8058view13:46, 7 January 2008MaintBot[[Pathway:Human:Focal adhesion KEGG]] moved to [[Pathway:Homo sapiens:Focal adhesion KEGG]]: Renaming species
7651view16:07, 18 December 2007MaintBotfixed category names
7222view12:41, 4 November 2007MaintBotAdded categories to GPML
6319view22:17, 22 May 2007169.230.77.174gpml file for [[Human:Focal_adhesion_KEGG]]

External references

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NameTypeDatabase referenceComment
TLN1GeneProduct7094 (Entrez Gene)
TNCGeneProduct3371 (Entrez Gene)
PIP3GeneProduct829662 (Entrez Gene)
TNRGeneProduct7143 (Entrez Gene)
PAK1GeneProduct5058 (Entrez Gene)
VTNGeneProduct7448 (Entrez Gene)
MAPK4GeneProduct5596 (Entrez Gene) MAPK4; mitogen-activated protein kinase 4 [EC:2.7.1.-]
VWFGeneProduct7450 (Entrez Gene)
ACTBGeneProduct60 (Entrez Gene)
LAMC1GeneProduct3915 (Entrez Gene)
BADGeneProduct572 (Entrez Gene)
LAMC3GeneProduct10319 (Entrez Gene)
TXKGeneProduct7294 (Entrez Gene)
TNNGeneProduct63923 (Entrez Gene)
MAP2K2GeneProduct5605 (Entrez Gene) MAP2K2; mitogen-activated protein kinase kinase 2 [EC:2.7.1.-]
COL5A3GeneProduct50509 (Entrez Gene)
AKT3GeneProduct10000 (Entrez Gene)
TNXBGeneProduct7148 (Entrez Gene)
PIK3R5GeneProduct23533 (Entrez Gene)
COL4A6GeneProduct1288 (Entrez Gene)
PDGFDGeneProduct80310 (Entrez Gene)
EGFGeneProduct1950 (Entrez Gene)
CCND1GeneProduct595 (Entrez Gene)
FIGFGeneProduct2277 (Entrez Gene)
PDGFRAGeneProduct5156 (Entrez Gene)
HGFGeneProduct3082 (Entrez Gene)
TNK1GeneProduct8711 (Entrez Gene)
IGF1GeneProduct3479 (Entrez Gene)
MAP2K6GeneProduct5608 (Entrez Gene) MAP2K6; mitogen-activated protein kinase kinase 6 [EC:2.7.1.-
PDGFAGeneProduct5154 (Entrez Gene)
ARHGAP5GeneProduct394 (Entrez Gene)
PDGFBGeneProduct5155 (Entrez Gene)
PDPK1GeneProduct5170 (Entrez Gene)
PGFGeneProduct5228 (Entrez Gene)
PPP1R12AGeneProduct4659 (Entrez Gene)
PELOGeneProduct53918 (Entrez Gene)
PIK3CDGeneProduct5293 (Entrez Gene)
ITGA2GeneProduct3673 (Entrez Gene)
VAV1GeneProduct7409 (Entrez Gene)
ITGA3GeneProduct3675 (Entrez Gene)
PAK7GeneProduct57144 (Entrez Gene)
ITGA4GeneProduct3676 (Entrez Gene)
BCAR1GeneProduct9564 (Entrez Gene)
ITGA5GeneProduct3678 (Entrez Gene)
BIRC4GeneProduct331 (Entrez Gene)
ITGA6GeneProduct3655 (Entrez Gene)
ITGA7GeneProduct3679 (Entrez Gene)
KDRGeneProduct3791 (Entrez Gene)
ITGA8GeneProduct8516 (Entrez Gene)
PTK6GeneProduct5753 (Entrez Gene)
ITGA9GeneProduct3680 (Entrez Gene)
STYK1GeneProduct55359 (Entrez Gene)
ITGA10GeneProduct8515 (Entrez Gene)
BRAFGeneProduct673 (Entrez Gene)
ITGA11GeneProduct22801 (Entrez Gene)
SEPP1GeneProductSepp1 (Entrez Gene) SEPP1; selenoprotein P plasma
ITGA2BGeneProduct3674 (Entrez Gene)
MAPK1GeneProduct5594 (Entrez Gene) MAPK1; mitogen-activated protein kinase 1 [EC:2.7.1.-]
ITGAEGeneProduct3682 (Entrez Gene)
MAP2K1GeneProduct5604 (Entrez Gene) MAP2K1; mitogen-activated protein kinase kinase 1 [EC:2.7.1.-]
ITGADGeneProduct3681 (Entrez Gene)
FARP2GeneProduct9855 (Entrez Gene)
ITGALGeneProduct3683 (Entrez Gene)
CAPN1GeneProduct823 (Entrez Gene)
ITGAMGeneProduct3684 (Entrez Gene)
AKT1GeneProduct207 (Entrez Gene)
ITGAVGeneProduct3685 (Entrez Gene)
ROCK2GeneProduct9475 (Entrez Gene)
ITGAXGeneProduct3687 (Entrez Gene)
MYLKGeneProduct4638 (Entrez Gene)
ITGB1GeneProduct3688 (Entrez Gene)
GSK3BGeneProduct2932 (Entrez Gene)
ITGB2GeneProduct3689 (Entrez Gene)
PIK3R2GeneProduct5296 (Entrez Gene)
ITGB3GeneProduct3690 (Entrez Gene)
PIK3CBGeneProduct5291 (Entrez Gene)
ITGB4GeneProduct3691 (Entrez Gene)
RAC2GeneProduct5880 (Entrez Gene)
ITGB5GeneProduct3693 (Entrez Gene)
PAK2GeneProduct5062 (Entrez Gene)
ITGB6GeneProduct3694 (Entrez Gene)
ELK1GeneProduct2002 (Entrez Gene)
ITGB8GeneProduct3696 (Entrez Gene)
VEGFBGeneProduct7423 (Entrez Gene)
RAP1AGeneProduct5906 (Entrez Gene) RAP1A; RAP1A member of RAS oncogene family
RAPGEF1GeneProduct2889 (Entrez Gene)
RAP1BGeneProduct5908 (Entrez Gene) RAP1B; RAP1B member of RAS oncogene family
BIRC2GeneProduct329 (Entrez Gene)
DOCK1GeneProduct1793 (Entrez Gene) DOCK1; dedicator of cyto-kinesis
MAPK9GeneProduct5601 (Entrez Gene)
SHC1GeneProduct6464 (Entrez Gene) SHC1; SHC (Src homology 2 domain containing) transforming protein 1
CCND3GeneProduct896 (Entrez Gene)
SHC3GeneProduct53358 (Entrez Gene) SHC3; neuronal Sh
SOS1GeneProduct6654 (Entrez Gene) SOS1; son of sevenless homolog 1 (Drosophila)
THBS4GeneProduct7060 (Entrez Gene)
ZYXGeneProduct7791 (Entrez Gene) ZYX; zyxin
METGeneProduct4233 (Entrez Gene)
CAV1GeneProduct857 (Entrez Gene) CAV1; caveolin 1 caveolae protein 22kD
PDGFRBGeneProduct5159 (Entrez Gene)
CAV3GeneProduct859 (Entrez Gene) CAV3; caveolin 3
SRMSGeneProduct6725 (Entrez Gene)
FYNGeneProduct2534 (Entrez Gene) FYN; FYN oncogene related to SRC FGR YES [EC:]
TESK2GeneProduct10420 (Entrez Gene)
GRB2GeneProduct2885 (Entrez Gene) GRB2; growth factor receptor-bound protein 2
TNK2GeneProduct10188 (Entrez Gene)
VASPGeneProduct7408 (Entrez Gene) VASP; vasodilator-stimulated phosphoprotein
ARAFGeneProduct369 (Entrez Gene) ARAF1; v-raf murine sarcoma 3611 viral oncogene homolog 1 [EC:2.7.1.-]
SRCGeneProduct6714 (Entrez Gene) SRC; v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian) [EC:]
RAF1GeneProduct5894 (Entrez Gene) RAF1; v-raf-1 murine leukemia viral oncogene homolog 1 [EC:2.7.1.-]
ILKGeneProduct3611 (Entrez Gene) ILK; integrin-linked kinase [EC:2.7.1.-]
MAPK7GeneProduct5598 (Entrez Gene) MAPK7; mitogen-activated protein kinase 7 [EC:2.7.1.-
CAV2GeneProduct858 (Entrez Gene) CAV2; caveolin 2
MAP2K5GeneProduct5607 (Entrez Gene) MAP2K5; mitogen-activated protein kinase kinase 5 [EC:2.7.1.-]
ACTN1GeneProduct87 (Entrez Gene)
MAPK12GeneProduct6300 (Entrez Gene) MAPK12; mitogen-activated protein kinase 12 [EC:2.7.1.-]
VCLGeneProduct7414 (Entrez Gene) VCL; vinculin
MAPK6GeneProduct5597 (Entrez Gene) MAPK6; mitogen-activated protein kinase 6 [EC:2.7.1.-]
CHADGeneProduct1101 (Entrez Gene)
MAP2K3GeneProduct5606 (Entrez Gene) MAP2K3; mitogen-activated protein kinase kinase 3 [EC:2.7.1.-]
COL11A1GeneProduct1301 (Entrez Gene)
PTK2GeneProduct5747 (Entrez Gene) PTK2; PTK2 protein tyrosine kinase 2 [EC:
COL11A2GeneProduct1302 (Entrez Gene)
RHOBGeneProduct388 (Entrez Gene)
COL2A1GeneProduct1280 (Entrez Gene)
FLNAGeneProduct2316 (Entrez Gene)
COL3A1GeneProduct1281 (Entrez Gene)
PXNGeneProduct5829 (Entrez Gene)
COL4A1GeneProduct1282 (Entrez Gene)
RHOAGeneProduct387 (Entrez Gene)
COL4A2GeneProduct1284 (Entrez Gene)
PARVBGeneProduct29780 (Entrez Gene)
COL4A4GeneProduct1286 (Entrez Gene)
AKT2GeneProduct208 (Entrez Gene)
COL5A1GeneProduct1289 (Entrez Gene)
ROCK1GeneProduct6093 (Entrez Gene)
COL5A2GeneProduct1290 (Entrez Gene)
PIP5K1CGeneProduct23396 (Entrez Gene)
COL6A2GeneProduct1292 (Entrez Gene)
MYL6GeneProduct4637 (Entrez Gene)
COL1A1GeneProduct1277 (Entrez Gene)
MYLK2GeneProduct85366 (Entrez Gene)
COL1A2GeneProduct1278 (Entrez Gene)
ACTG1GeneProduct71 (Entrez Gene)
COMPGeneProduct1311 (Entrez Gene)
PIK3CAGeneProduct5290 (Entrez Gene)
FN1GeneProduct2335 (Entrez Gene)
PIK3R1GeneProduct5295 (Entrez Gene)
IBSPGeneProduct3381 (Entrez Gene)
PIK3CGGeneProduct5294 (Entrez Gene)
LAMA2GeneProduct3908 (Entrez Gene)
PIK3R4GeneProduct30849 (Entrez Gene)
LAMA3GeneProduct3909 (Entrez Gene)
PTENGeneProduct5728 (Entrez Gene)
LAMA4GeneProduct3910 (Entrez Gene)
RAC1GeneProduct5879 (Entrez Gene)
LAMA5GeneProduct3911 (Entrez Gene)
RAC3GeneProduct5881 (Entrez Gene)
LAMB1GeneProduct3912 (Entrez Gene)
PAK3GeneProduct5063 (Entrez Gene)
LAMB2GeneProduct3913 (Entrez Gene)
PAK4GeneProduct10298 (Entrez Gene)
LAMC2GeneProduct3918 (Entrez Gene)
PAK6GeneProduct56924 (Entrez Gene)
RELNGeneProduct5649 (Entrez Gene)
PDGFCGeneProduct56034 (Entrez Gene)
SPP1GeneProduct6696 (Entrez Gene)
VEGFGeneProductVEGF (Entrez Gene)
THBS1GeneProduct7057 (Entrez Gene)
VEGFCGeneProduct7424 (Entrez Gene)
THBS2GeneProduct7058 (Entrez Gene)
CRKGeneProduct1398 (Entrez Gene)
THBS3GeneProduct7059 (Entrez Gene)
CDC42GeneProduct998 (Entrez Gene)
LAMB3GeneProduct3914 (Entrez Gene)
BCL2GeneProduct596 (Entrez Gene)
LAMA1GeneProduct284217 (Entrez Gene)
BIRC3GeneProduct330 (Entrez Gene)
BLKGeneProduct640 (Entrez Gene)
MAPK8GeneProduct5599 (Entrez Gene)
EGFRGeneProduct1956 (Entrez Gene)
JUNGeneProduct3725 (Entrez Gene)
ERBB2GeneProduct2064 (Entrez Gene)
CCND2GeneProduct894 (Entrez Gene)
FGRGeneProduct2268 (Entrez Gene)
ITGB7GeneProduct3695 (Entrez Gene)
FLT1GeneProduct2321 (Entrez Gene)
HCKGeneProduct3055 (Entrez Gene)
IGF1RGeneProduct3480 (Entrez Gene)
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