Parkin-Ubiquitin Proteasomal System pathway (Homo sapiens)

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This pathway describes the Parkin-Ubiquitin proteasome degradation system.

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Ontology Terms



  1. Smith SB, Dampier W, Tozeren A, Brown JR, Magid-Slav M; ''Identification of common biological pathways and drug targets across multiple respiratory viruses based on human host gene expression analysis.''; PLoS One, 2012 PubMed


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72121view23:35, 24 October 2013AlexanderPicoadd xref to pathway datanode
72120view23:27, 24 October 2013AlexanderPicotesting tag update
72119view23:26, 24 October 2013AlexanderPicotesting tag update; removed old category
71356view18:35, 17 October 2013MaintBotAutomated update of data sources
68883view17:26, 8 July 2013MaintBotUpdated to 2013 gpml schema
67576view11:28, 26 June 2013DdiglesOntology Term : 'ubiquitin/proteasome degradation pathway' added !
59316view19:02, 25 February 2013MaintBotModified description
59088view22:07, 21 February 2013MaintBotUpdated Ensembl and UniProt data source
57681view20:49, 31 January 2013KhanspersModified categories
53587view19:36, 9 November 2012KhanspersVersion 1 finished
53586view19:33, 9 November 2012KhanspersPeriodical save, work in progress
53585view19:23, 9 November 2012KhanspersPeriodical save, work in progress
53584view19:12, 9 November 2012KhanspersPeriodical save, work in progress
53583view19:02, 9 November 2012KhanspersPeriodical save, work in progress
53544view20:34, 8 November 2012KhanspersAdded lit ref
53543view20:32, 8 November 2012KhanspersPeriodical save
53541view20:21, 8 November 2012KhanspersPeriodical save, work in progress
53540view20:10, 8 November 2012KhanspersPeriodical save, work in progress
53531view19:21, 8 November 2012KhanspersPeriodical save, work in progress
53529view19:10, 8 November 2012KhanspersPeriodical save, work in progress
53466view20:48, 7 November 2012KhanspersNew pathway - first draft
53465view20:44, 7 November 2012KhanspersPeriodical save, work in progress
53464view20:33, 7 November 2012KhanspersNew pathway

External references


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NameTypeDatabase referenceComment
Alpha-synucleinGeneProduct6622 (Entrez Gene)
CASKGeneProduct8573 (Entrez Gene)
CHIPGeneProduct10273 (Entrez Gene)
Caspase-1GeneProduct834 (Entrez Gene)
Caspase-8GeneProduct841 (Entrez Gene)
Cullin 1GeneProduct8454 (Entrez Gene)
Cyclin EGeneProduct898 (Entrez Gene)
DORFINGeneProduct25897 (Entrez Gene)
FBXW7GeneProduct55294 (Entrez Gene)
HSPA14GeneProduct51182 (Entrez Gene)
HSPA1AGeneProduct3303 (Entrez Gene)
HSPA1BGeneProduct3304 (Entrez Gene)
HSPA1LGeneProduct3305 (Entrez Gene)
HSPA2GeneProduct3306 (Entrez Gene)
HSPA4GeneProduct3308 (Entrez Gene)
HSPA5GeneProduct3309 (Entrez Gene)
HSPA6GeneProduct3310 (Entrez Gene)
HSPA7GeneProductENSG00000225217 (Ensembl)
HSPA8GeneProduct3312 (Entrez Gene)
HSPA9GeneProduct3313 (Entrez Gene)
PAELRGeneProduct2861 (Entrez Gene)
PSMC1GeneProduct5700 (Entrez Gene)
PSMC2GeneProduct5701 (Entrez Gene)
PSMC3GeneProduct5702 (Entrez Gene)
PSMC4GeneProduct5704 (Entrez Gene)
PSMC5GeneProduct5705 (Entrez Gene)
PSMC6GeneProduct5706 (Entrez Gene)
PSMD10GeneProduct5716 (Entrez Gene)
PSMD11GeneProduct5717 (Entrez Gene)
PSMD12GeneProduct5718 (Entrez Gene)
PSMD13GeneProduct5719 (Entrez Gene)
PSMD14GeneProduct10213 (Entrez Gene)
PSMD1GeneProduct5707 (Entrez Gene)
PSMD2GeneProduct5708 (Entrez Gene)
PSMD3GeneProduct5709 (Entrez Gene)
PSMD4GeneProduct5710 (Entrez Gene)
PSMD5GeneProduct5711 (Entrez Gene)
PSMD6GeneProduct9861 (Entrez Gene)
PSMD7GeneProduct5713 (Entrez Gene)
PSMD8GeneProduct5714 (Entrez Gene)
PSMD9GeneProduct5715 (Entrez Gene)
ParkinGeneProduct5071 (Entrez Gene)
Proteasomal DegradationPathwayWP183 (WikiPathways)
SIAH1GeneProduct6477 (Entrez Gene)
SIAH2GeneProduct6478 (Entrez Gene)
Septin 5GeneProduct5413 (Entrez Gene)
Synphilin 1GeneProduct9627 (Entrez Gene)
TUBA1AGeneProduct7846 (Entrez Gene)
TUBA1BGeneProduct10376 (Entrez Gene)
TUBA1CGeneProduct84790 (Entrez Gene)
TUBA3CGeneProduct7278 (Entrez Gene)
TUBA3DGeneProduct113457 (Entrez Gene)
TUBA3EGeneProduct112714 (Entrez Gene)
TUBA4AGeneProduct7277 (Entrez Gene)
TUBA4BGeneProductENSG00000243910 (Ensembl)
TUBA8GeneProduct51807 (Entrez Gene)
TUBAL3GeneProduct79861 (Entrez Gene)
TUBB1GeneProduct81027 (Entrez Gene)
TUBBGeneProduct203068 (Entrez Gene)
TUBB2AGeneProduct7280 (Entrez Gene)
TUBB2BGeneProduct347733 (Entrez Gene)
TUBB2CGeneProduct10383 (Entrez Gene)
TUBB3GeneProduct10381 (Entrez Gene)
TUBB4GeneProduct10382 (Entrez Gene)
TUBB4QGeneProduct56604 (Entrez Gene)
TUBB6GeneProduct84617 (Entrez Gene)
TUBB8GeneProduct347688 (Entrez Gene)
UBCH7GeneProduct7332 (Entrez Gene)
UBCH8GeneProduct9246 (Entrez Gene)
UBE1GeneProduct7317 (Entrez Gene)
UBE2G1GeneProduct7326 (Entrez Gene)
UBE2G2GeneProduct7327 (Entrez Gene)
UBE2J1GeneProduct51465 (Entrez Gene)
UBE2J2GeneProduct118424 (Entrez Gene)

Annotated Interactions

No annotated interactions

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