Vitamin B6 (pyridoxine, pyridoxal, pyridoxamine) biosynthesis and salvage pathway (Zea mays)

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Description

Several forms of the vitamin are known, but pyridoxal 5’-phosphate (PLP) is the biologically active form and is a cofactor in various reactions of amino acid metabolism, including transamination, deamination, and decarboxylation, racemization and others. In plants PLP is synthesized de novo in the cytosol by the two-protein (PDX1/PDX2) PLP synthase complex from pentose phosphate, triose phosphate, and glutamine pre-cursors (reviewed in Fitzpatrick, 2011). PLP can also be made in chloroplasts or cytosol from pyridoxamine 5'-phosphate (PMP) or pyridoxine 5'-phosphate (PNP) by the salvage enzyme pyridoxamine 5'-phosphate oxidase. Pyridoxine glucosides are major forms of vitamin B6 in plants (Gregory and Ink, 1987). The details of vitamin B6 biosynthesis (especially its compartmentation) in plants are far from being elucidated. This diagram is an attempt to capture the current state of the art

Ontology Tags

 

Bibliography

  1. Gerdes S, Lerma-Ortiz C, Frelin O, Seaver SM, Henry CS, de Crécy-Lagard V, Hanson AD; ''Plant B Vitamin Pathways and their Compartmentation: a Guide for the Perplexed.''; J Exp Bot, 2012 PubMed

History

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CompareRevisionActionTimeUserComment
73526view23:37, 29 January 2014KhanspersModified title
71902view17:51, 22 October 2013MaintBotRemoved source from datanodes with empty id
70256view21:41, 15 July 2013MaintBotupdated to 2013 schema
65176view19:12, 5 June 2013MaintBotModified categories
55416view19:07, 14 December 2012SvetaGModified title
54618view06:28, 5 December 2012SvetaGModified description
54617view06:07, 5 December 2012SvetaGPeriodical save, work in progress
54616view05:47, 5 December 2012SvetaGPeriodical save, work in progress
54615view05:35, 5 December 2012SvetaGSpecify description
54614view04:40, 5 December 2012SvetaGPeriodical save, work in progress
54326view23:28, 27 November 2012SvetaGSpecify description
54325view23:27, 27 November 2012SvetaGPeriodical save, work in progress
54324view23:20, 27 November 2012SvetaGSpecify description
54323view23:15, 27 November 2012SvetaGSpecify description
53372view00:31, 6 November 2012PjaiswalModified title
53197view23:43, 30 October 2012PjaiswalModified categories
53104view01:06, 30 October 2012MaintBotModified categories
53098view21:28, 29 October 2012PjaiswalOntology Term : 'vitamin B6 metabolic pathway' added !
53097view21:27, 29 October 2012PjaiswalOntology Term : 'plant cell' added !
53096view21:27, 29 October 2012PjaiswalModified categories
53095view21:26, 29 October 2012PjaiswalNew pathway

External references

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NameTypeDatabase referenceComment
PO4Metabolite
pyridoxal 5'-phosphateMetabolite
D-ribulose 5-PMetabolite
1.4.3.5GeneProduct1.4.3.5 (Enzyme Nomenclature)
pyridoxamine 5'-phosphateMetabolite
pyridoxalMetabolite
(photo)chemical / enzymatic pyridoxal oxidationGeneProduct
2.7.1.35GeneProduct2.7.1.35 (Enzyme Nomenclature)
GRMZM2G069758GeneProductGRMZM2G069758 (Gramene Maize)
ATPMetabolite
Dihydroxyacetone-PMetabolite
vitamin B6 transporterGeneProduct
H2OMetabolite
D-glyceraldehyde 3-PMetabolite
2.6.1.30GeneProduct2.6.1.30 (Enzyme Nomenclature)
PDX2GeneProduct
GRMZM2G023528GeneProductGRMZM2G023528 (Gramene Maize)
5'-O-beta-D-glucosylpyridoxineMetabolite
GRMZM2G022130GeneProductGRMZM2G022130 (Gramene Maize)
2.4.1.160GeneProduct2.4.1.160 (Enzyme Nomenclature)
PDX1GeneProduct
GRMZM2G120652GeneProductGRMZM2G120652 (Gramene Maize)
D-ribose 5PMetabolite
pyridoxamineMetabolite
glycosylpyridoxine hydrolaseGeneProduct
pyridoxineMetabolite
D-glucoseMetabolite
PLP-dependent enzyme side-activityGeneProduct
4-pyridoxic acidMetabolite
1.1.1.65GeneProduct1.1.1.65 (Enzyme Nomenclature)
3.1.3.74GeneProduct3.1.3.74 (Enzyme Nomenclature)
ADPMetabolite
GRMZM5G850015GeneProductGRMZM5G850015 (Gramene Maize)
O2Metabolite
GRMZM2G061988GeneProductGRMZM2G061988 (Gramene Maize)
H2O2Metabolite
GRMZM2G398107GeneProductGRMZM2G398107 (Gramene Maize)
NH3Metabolite
ORMetabolite
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