Alzheimers Disease (Homo sapiens)

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Description

This pathway displays current genes, proteolytic events and other processes associated with the progression of Alzheimer's disease. This pathway was adapted from KEGG on 10/7/2011. Note: mitochondrial associated genes Cx I through Cx V are not currently included, as these correspond to over a hundred distinct factors. See below source URL for more information. Source: KEGG (http://www.genome.jp/kegg/pathway/hsa/hsa05010.html)

Comments

 
Adapted from KEGG

Ontology Tags

 

Bibliography

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History

View all...
CompareRevisionActionTimeUserComment
71384view18:40, 17 October 2013MaintBotAutomated update of data sources
63153view20:17, 8 May 2013MaintBotUpdating GPML version
59190view19:07, 22 February 2013MaintBotUpdated Ensembl and UniProt data source
45384view03:10, 8 October 2011NsalomonisAdded missing edges
45375view21:24, 7 October 2011KhanspersModified categories
45313view20:05, 7 October 2011NsalomonisModified description
45307view20:04, 7 October 2011NsalomonisModified description
45302view20:01, 7 October 2011Nsalomonisfinished initial layout
45300view19:49, 7 October 2011NsalomonisSpecify description
45299view19:44, 7 October 2011NsalomonisPeriodical save, work in progress
45298view19:38, 7 October 2011NsalomonisSpecify description
45297view19:34, 7 October 2011NsalomonisPeriodical save, work in progress
45267view18:48, 7 October 2011NsalomonisSpecify description
45259view18:44, 7 October 2011NsalomonisPeriodical save, work in progress
45240view18:22, 7 October 2011NsalomonisSpecify description
45237view18:13, 7 October 2011NsalomonisPeriodical save, work in progress
45236view18:12, 7 October 2011NsalomonisSpecify description
45235view17:53, 7 October 2011NsalomonisPeriodical save, work in progress
45232view17:43, 7 October 2011NsalomonisPeriodical save, work in progress
45224view17:33, 7 October 2011NsalomonisPeriodical save, work in progress
45210view17:23, 7 October 2011NsalomonisPeriodical save, work in progress
45206view17:13, 7 October 2011NsalomonisPeriodical save, work in progress
45205view17:02, 7 October 2011NsalomonisPeriodical save, work in progress
45169view06:40, 7 October 2011ThomasOntology Term : 'Alzheimers Dementia' added !
45168view06:40, 7 October 2011ThomasOntology Term : 'Alzheimer disease pathway' added !
45167view05:45, 7 October 2011NsalomonisSpecify description
45166view05:39, 7 October 2011NsalomonisPeriodical save, work in progress
45163view05:10, 7 October 2011NsalomonisSpecify description
45162view05:02, 7 October 2011NsalomonisPeriodical save, work in progress
45161view04:51, 7 October 2011NsalomonisPeriodical save, work in progress
45160view04:39, 7 October 2011NsalomonisPeriodical save, work in progress
45159view04:19, 7 October 2011NsalomonisPeriodical save, work in progress
45158view04:09, 7 October 2011NsalomonisPeriodical save, work in progress
45157view03:59, 7 October 2011NsalomonisPeriodical save, work in progress
45156view03:49, 7 October 2011NsalomonisPeriodical save, work in progress
45155view03:38, 7 October 2011NsalomonisPeriodical save, work in progress
45154view03:28, 7 October 2011NsalomonisPeriodical save, work in progress
45153view03:18, 7 October 2011NsalomonisPeriodical save, work in progress
45119view23:31, 6 October 2011NsalomonisSpecify description
45118view23:30, 6 October 2011NsalomonisPeriodical save, work in progress
45114view23:20, 6 October 2011NsalomonisPeriodical save, work in progress
45109view22:36, 6 October 2011NsalomonisPeriodical save, work in progress
45104view22:25, 6 October 2011NsalomonisPeriodical save, work in progress
45100view22:05, 6 October 2011NsalomonisNew pathway

External references

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NameTypeDatabase referenceComment
GPCRGeneProduct
TP53GeneProductENSG00000141510 (Ensembl)
APPBP1GeneProductENSG00000159593 (Ensembl)
IL1BGeneProductENSG00000125538 (Ensembl)
ApoptosisPathwayWP254 (WikiPathways)
PPP3R2GeneProductENSG00000188386 (Ensembl)
Oxidative PhosphorylationPathwayWP623 (WikiPathways)
CACNA1FGeneProductENSG00000102001 (Ensembl)
Modulation of gene expressionPathwayWP1821 (WikiPathways)
EIF2AK3GeneProductENSG00000172071 (Ensembl)
Induction of ApoptosisPathwayWP1896 (WikiPathways)
DNA damagePathway
Cell DeathPathway
APAF1GeneProductENSG00000120868 (Ensembl)
IP3MetaboliteHMDB01498 (HMDB)
GRIN2BGeneProductENSG00000150086 (Ensembl)
CalciumMetaboliteHMDB00464 (HMDB)
PLCB2GeneProductENSG00000137841 (Ensembl)
IronMetaboliteHMDB00692 (HMDB)
RYR3GeneProductENSG00000198838 (Ensembl)
CopperMetaboliteHMDB00657 (HMDB)
ITPR2GeneProductENSG00000123104 (Ensembl)
Hydrogen peroxideMetaboliteHMDB03125 (HMDB)
TAUGeneProductENSG00000186868 (Ensembl)
Neuronal InjuryPathway
APPGeneProductENSG00000142192 (Ensembl)
Calcium Signaling PathwayPathway
ADAM17GeneProductENSG00000151694 (Ensembl)
Protein oxidationPathway
CASP3GeneProductENSG00000164305 (Ensembl)
NOMetaboliteHMDB03378 (HMDB)
CACNA1CGeneProductENSG00000151067 (Ensembl)
APBB1GeneProductENSG00000166313 (Ensembl)
GRIN2DGeneProductENSG00000105464 (Ensembl)
GAPDHGeneProductENSG00000111640 (Ensembl)
GNAQGeneProductENSG00000156052 (Ensembl)
ADAM10GeneProductENSG00000137845 (Ensembl)
PLCB4GeneProductENSG00000101333 (Ensembl)
BACE1GeneProductENSG00000186318 (Ensembl)
MAPK3GeneProductENSG00000102882 (Ensembl)
PSENENGeneProductENSG00000205155 (Ensembl)
ATP2A1GeneProductENSG00000196296 (Ensembl)
PSEN1GeneProductENSG00000080815 (Ensembl)
ATF6GeneProductENSG00000118217 (Ensembl)
NCSTNGeneProductENSG00000162736 (Ensembl)
CAPN1GeneProductENSG00000014216 (Ensembl)
APH1AGeneProductENSG00000117362 (Ensembl)
NOS1GeneProductENSG00000089250 (Ensembl)
IDEGeneProductENSG00000119912 (Ensembl)
CASP7GeneProductENSG00000165806 (Ensembl)
MMEGeneProductENSG00000196549 (Ensembl)
Lipid peroxidationPathwayWP1878 (WikiPathways)
LPLGeneProductENSG00000175445 (Ensembl)
PPP3R1GeneProductENSG00000221823 (Ensembl)
APOEGeneProductENSG00000130203 (Ensembl)
CHP2GeneProduct63928 (Entrez Gene)
LRP1GeneProductENSG00000123384 (Ensembl)
PSEN2GeneProductENSG00000143801 (Ensembl)
FASGeneProductENSG00000026103 (Ensembl)
CASP9GeneProductENSG00000132906 (Ensembl)
TNFRSF1AGeneProductENSG00000067182 (Ensembl)
SNCAGeneProductENSG00000145335 (Ensembl)
FADDGeneProductENSG00000168040 (Ensembl)
GRIN1GeneProductENSG00000176884 (Ensembl)
CASP8GeneProductENSG00000064012 (Ensembl)
GRIN2AGeneProductENSG00000183454 (Ensembl)
Cx IGeneProduct
GRIN2CGeneProductENSG00000161509 (Ensembl)
Cx IIGeneProduct
CACNA1DGeneProductENSG00000157388 (Ensembl)
Cx IIIGeneProduct
CACNA1SGeneProductENSG00000081248 (Ensembl)
Cx IVGeneProduct
PLCB1GeneProductENSG00000182621 (Ensembl)
Cx VGeneProduct
PLCB3GeneProductENSG00000149782 (Ensembl)
APP processingPathway
TNFGeneProductENSG00000232810 (Ensembl)
Lower energy production?Pathway
MAPK1GeneProductENSG00000100030 (Ensembl)
HSD17B10GeneProductENSG00000072506 (Ensembl)
CASP12GeneProductENSG00000204403 (Ensembl)
BIDGeneProductENSG00000015475 (Ensembl)
ATP2A2GeneProductENSG00000174437 (Ensembl)
CYCSGeneProductENSG00000172115 (Ensembl)
ATP2A3GeneProductENSG00000074370 (Ensembl)
CALM1GeneProductENSG00000198668 (Ensembl)
ERN1GeneProductENSG00000178607 (Ensembl)
CHPGeneProduct11261 (Entrez Gene)
ITPR1GeneProductENSG00000150995 (Ensembl)
BADGeneProductENSG00000002330 (Ensembl)
ITPR3GeneProductENSG00000096433 (Ensembl)
CALM2GeneProductENSG00000143933 (Ensembl)
CAPN2GeneProductENSG00000162909 (Ensembl)
CALM3GeneProductENSG00000160014 (Ensembl)
CDK5R1GeneProductENSG00000176749 (Ensembl)
CALML3GeneProductENSG00000178363 (Ensembl)
CDK5GeneProductENSG00000164885 (Ensembl)
CALML5GeneProductENSG00000178372 (Ensembl)
GSK3BGeneProductENSG00000082701 (Ensembl)
PPP3CAGeneProductENSG00000138814 (Ensembl)
Mitochondrial dysfunctionPathway
PPP3CBGeneProductENSG00000107758 (Ensembl)
InflammationPathwayWP453 (WikiPathways)
PPP3CCGeneProductENSG00000120910 (Ensembl)
ONOO-MetaboliteHMDB02179 (HMDB)
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