Alzheimers Disease (Homo sapiens)

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Description

This pathway displays current genes, proteolytic events and other processes associated with the progression of Alzheimer's disease. This pathway was adapted from KEGG on 10/7/2011. Note: mitochondrial associated genes Cx I through Cx V are not currently included, as these correspond to over a hundred distinct factors. See below source URL for more information. Source: KEGG (http://www.genome.jp/kegg/pathway/hsa/hsa05010.html)

Comments

 
Adapted from KEGG

Ontology Tags

 

Bibliography

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  2. Takuma K, Yan SS, Stern DM, Yamada K; ''Mitochondrial dysfunction, endoplasmic reticulum stress, and apoptosis in Alzheimer's disease.''; J Pharmacol Sci, 2005 PubMed
  3. Bezprozvanny I, Mattson MP; ''Neuronal calcium mishandling and the pathogenesis of Alzheimer's disease.''; Trends Neurosci, 2008 PubMed
  4. Hölscher C; ''Possible causes of Alzheimer's disease: amyloid fragments, free radicals, and calcium homeostasis.''; Neurobiol Dis, 1998 PubMed
  5. Bojarski L, Herms J, Kuznicki J; ''Calcium dysregulation in Alzheimer's disease.''; Neurochem Int, 2008 PubMed
  6. Katayama T, Imaizumi K, Manabe T, Hitomi J, Kudo T, Tohyama M; ''Induction of neuronal death by ER stress in Alzheimer's disease.''; J Chem Neuroanat, 2004 PubMed
  7. Small DH, Mok SS, Bornstein JC; ''Alzheimer's disease and Abeta toxicity: from top to bottom.''; Nat Rev Neurosci, 2001 PubMed
  8. Mattson MP; ''Pathways towards and away from Alzheimer's disease.''; Nature, 2004 PubMed
  9. Parihar MS, Hemnani T; ''Alzheimer's disease pathogenesis and therapeutic interventions.''; J Clin Neurosci, 2004 PubMed
  10. Cowburn RF, Popescu BO, Ankarcrona M, Dehvari N, Cedazo-Minguez A; ''Presenilin-mediated signal transduction.''; Physiol Behav, 2007 PubMed
  11. Shen Y, He P, Zhong Z, McAllister C, Lindholm K; ''Distinct destructive signal pathways of neuronal death in Alzheimer's disease.''; Trends Mol Med, 2006 PubMed
  12. Reese LC, Zhang W, Dineley KT, Kayed R, Taglialatela G; ''Selective induction of calcineurin activity and signaling by oligomeric amyloid beta.''; Aging Cell, 2008 PubMed
  13. Lee MS, Kwon YT, Li M, Peng J, Friedlander RM, Tsai LH; ''Neurotoxicity induces cleavage of p35 to p25 by calpain.''; Nature, 2000 PubMed
  14. Hauptmann S, Keil U, Scherping I, Bonert A, Eckert A, Müller WE; ''Mitochondrial dysfunction in sporadic and genetic Alzheimer's disease.''; Exp Gerontol, 2006 PubMed
  15. Avila J; ''Tau phosphorylation and aggregation in Alzheimer's disease pathology.''; FEBS Lett, 2006 PubMed
  16. Ivins KJ, Thornton PL, Rohn TT, Cotman CW; ''Neuronal apoptosis induced by beta-amyloid is mediated by caspase-8.''; Neurobiol Dis, 1999 PubMed
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History

View all...
CompareRevisionActionTimeUserComment
75217view20:21, 9 May 2014KhanspersAdding lit refs
75209view20:04, 9 May 2014KhanspersAdded states, fixed missing xrefs, changed some pathway nodes to labels
71384view18:40, 17 October 2013MaintBotAutomated update of data sources
63153view20:17, 8 May 2013MaintBotUpdating GPML version
59190view19:07, 22 February 2013MaintBotUpdated Ensembl and UniProt data source
45384view03:10, 8 October 2011NsalomonisAdded missing edges
45375view21:24, 7 October 2011KhanspersModified categories
45313view20:05, 7 October 2011NsalomonisModified description
45307view20:04, 7 October 2011NsalomonisModified description
45302view20:01, 7 October 2011Nsalomonisfinished initial layout
45300view19:49, 7 October 2011NsalomonisSpecify description
45299view19:44, 7 October 2011NsalomonisPeriodical save, work in progress
45298view19:38, 7 October 2011NsalomonisSpecify description
45297view19:34, 7 October 2011NsalomonisPeriodical save, work in progress
45267view18:48, 7 October 2011NsalomonisSpecify description
45259view18:44, 7 October 2011NsalomonisPeriodical save, work in progress
45240view18:22, 7 October 2011NsalomonisSpecify description
45237view18:13, 7 October 2011NsalomonisPeriodical save, work in progress
45236view18:12, 7 October 2011NsalomonisSpecify description
45235view17:53, 7 October 2011NsalomonisPeriodical save, work in progress
45232view17:43, 7 October 2011NsalomonisPeriodical save, work in progress
45224view17:33, 7 October 2011NsalomonisPeriodical save, work in progress
45210view17:23, 7 October 2011NsalomonisPeriodical save, work in progress
45206view17:13, 7 October 2011NsalomonisPeriodical save, work in progress
45205view17:02, 7 October 2011NsalomonisPeriodical save, work in progress
45169view06:40, 7 October 2011ThomasOntology Term : 'Alzheimers Dementia' added !
45168view06:40, 7 October 2011ThomasOntology Term : 'Alzheimer disease pathway' added !
45167view05:45, 7 October 2011NsalomonisSpecify description
45166view05:39, 7 October 2011NsalomonisPeriodical save, work in progress
45163view05:10, 7 October 2011NsalomonisSpecify description
45162view05:02, 7 October 2011NsalomonisPeriodical save, work in progress
45161view04:51, 7 October 2011NsalomonisPeriodical save, work in progress
45160view04:39, 7 October 2011NsalomonisPeriodical save, work in progress
45159view04:19, 7 October 2011NsalomonisPeriodical save, work in progress
45158view04:09, 7 October 2011NsalomonisPeriodical save, work in progress
45157view03:59, 7 October 2011NsalomonisPeriodical save, work in progress
45156view03:49, 7 October 2011NsalomonisPeriodical save, work in progress
45155view03:38, 7 October 2011NsalomonisPeriodical save, work in progress
45154view03:28, 7 October 2011NsalomonisPeriodical save, work in progress
45153view03:18, 7 October 2011NsalomonisPeriodical save, work in progress
45119view23:31, 6 October 2011NsalomonisSpecify description
45118view23:30, 6 October 2011NsalomonisPeriodical save, work in progress
45114view23:20, 6 October 2011NsalomonisPeriodical save, work in progress
45109view22:36, 6 October 2011NsalomonisPeriodical save, work in progress
45104view22:25, 6 October 2011NsalomonisPeriodical save, work in progress
45100view22:05, 6 October 2011NsalomonisNew pathway

External references

View all...
NameTypeDatabase referenceComment
GRIN2AGeneProductENSG00000183454 (Ensembl)
CDK5GeneProductENSG00000164885 (Ensembl)
APPBP1GeneProductENSG00000159593 (Ensembl)
CASP12GeneProductENSG00000204403 (Ensembl)
ApoptosisPathwayWP254 (WikiPathways)
PSEN2GeneProductENSG00000143801 (Ensembl)
Oxidative PhosphorylationPathwayWP623 (WikiPathways)
PLCB1GeneProductENSG00000182621 (Ensembl)
Modulation of gene expressionPathwayWP1821 (WikiPathways)
ITPR1GeneProductENSG00000150995 (Ensembl)
Induction of ApoptosisPathwayWP1896 (WikiPathways)
APPGeneProductENSG00000142192 (Ensembl)
IP3MetaboliteHMDB01498 (HMDB)
SNCAGeneProductENSG00000145335 (Ensembl)
CalciumMetaboliteHMDB00464 (HMDB)
CACNA1DGeneProductENSG00000157388 (Ensembl)
IronMetaboliteHMDB00692 (HMDB)
TNFGeneProductENSG00000232810 (Ensembl)
CopperMetaboliteHMDB00657 (HMDB)
ATP2A3GeneProductENSG00000074370 (Ensembl)
Hydrogen peroxideMetaboliteHMDB03125 (HMDB)
CAPN2GeneProductENSG00000162909 (Ensembl)
Calcium Signaling PathwayPathway
DNA damagePathway
Protein oxidationPathway
CHP2GeneProduct63928 (Entrez Gene)
NOMetaboliteHMDB03378 (HMDB)
CASP9GeneProductENSG00000132906 (Ensembl)
APBB1GeneProductENSG00000166313 (Ensembl)
GRIN1GeneProductENSG00000176884 (Ensembl)
GAPDHGeneProductENSG00000111640 (Ensembl)
GRIN2CGeneProductENSG00000161509 (Ensembl)
ADAM10GeneProductENSG00000137845 (Ensembl)
CACNA1SGeneProductENSG00000081248 (Ensembl)
BACE1GeneProductENSG00000186318 (Ensembl)
PLCB3GeneProductENSG00000149782 (Ensembl)
PSENENGeneProductENSG00000205155 (Ensembl)
MAPK1GeneProductENSG00000100030 (Ensembl)
PSEN1GeneProductENSG00000080815 (Ensembl)
ATP2A2GeneProductENSG00000174437 (Ensembl)
NCSTNGeneProductENSG00000162736 (Ensembl)
ERN1GeneProductENSG00000178607 (Ensembl)
APH1AGeneProductENSG00000117362 (Ensembl)
ITPR3GeneProductENSG00000096433 (Ensembl)
IDEGeneProductENSG00000119912 (Ensembl)
CDK5R1GeneProductENSG00000176749 (Ensembl)
MMEGeneProductENSG00000196549 (Ensembl)
GSK3BGeneProductENSG00000082701 (Ensembl)
LPLGeneProductENSG00000175445 (Ensembl)
Lipid peroxidationPathwayWP1878 (WikiPathways)
APOEGeneProductENSG00000130203 (Ensembl)
PPP3R2GeneProductENSG00000188386 (Ensembl)
LRP1GeneProductENSG00000123384 (Ensembl)
ADAM17GeneProductENSG00000151694 (Ensembl)
FASGeneProductENSG00000026103 (Ensembl)
APAF1GeneProductENSG00000120868 (Ensembl)
TNFRSF1AGeneProductENSG00000067182 (Ensembl)
CASP3GeneProductENSG00000164305 (Ensembl)
FADDGeneProductENSG00000168040 (Ensembl)
GPCRGeneProduct
CASP8GeneProductENSG00000064012 (Ensembl)
CACNA1CGeneProductENSG00000151067 (Ensembl)
Cx IGeneProduct
GRIN2BGeneProductENSG00000150086 (Ensembl)
Cx IIGeneProduct
GRIN2DGeneProductENSG00000105464 (Ensembl)
Cx IIIGeneProduct
CACNA1FGeneProductENSG00000102001 (Ensembl)
Cx IVGeneProduct
GNAQGeneProductENSG00000156052 (Ensembl)
Cx VGeneProduct
PLCB2GeneProductENSG00000137841 (Ensembl)
APP processingPathway
PLCB4GeneProductENSG00000101333 (Ensembl)
HSD17B10GeneProductENSG00000072506 (Ensembl)
IL1BGeneProductENSG00000125538 (Ensembl)
BIDGeneProductENSG00000015475 (Ensembl)
MAPK3GeneProductENSG00000102882 (Ensembl)
CYCSGeneProductENSG00000172115 (Ensembl)
RYR3GeneProductENSG00000198838 (Ensembl)
CALM1GeneProductENSG00000198668 (Ensembl)
ATP2A1GeneProductENSG00000196296 (Ensembl)
CHPGeneProduct11261 (Entrez Gene)
EIF2AK3GeneProductENSG00000172071 (Ensembl)
BADGeneProductENSG00000002330 (Ensembl)
ATF6GeneProductENSG00000118217 (Ensembl)
CALM2GeneProductENSG00000143933 (Ensembl)
ITPR2GeneProductENSG00000123104 (Ensembl)
CALM3GeneProductENSG00000160014 (Ensembl)
CAPN1GeneProductENSG00000014216 (Ensembl)
CALML3GeneProductENSG00000178363 (Ensembl)
TP53GeneProductENSG00000141510 (Ensembl)
CALML5GeneProductENSG00000178372 (Ensembl)
NOS1GeneProductENSG00000089250 (Ensembl)
PPP3CAGeneProductENSG00000138814 (Ensembl)
TAUGeneProductENSG00000186868 (Ensembl)
PPP3CBGeneProductENSG00000107758 (Ensembl)
CASP7GeneProductENSG00000165806 (Ensembl)
PPP3CCGeneProductENSG00000120910 (Ensembl)
InflammationPathwayWP453 (WikiPathways)
PPP3R1GeneProductENSG00000221823 (Ensembl)
ONOO-MetaboliteHMDB02179 (HMDB)
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