Integrated Breast Cancer Pathway (Homo sapiens)

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Curation Tags

Description

This pathway incorporates the most important proteins for Breast Cancer. The Rp score from the Connectivity-Maps (C-Maps) webserver was used to determine the rank of the most important proteins in Breast Cancer. These proteins were then used to determine the most important pathways involved in Breast Cancer by using the Human Pathway Database (HPD). The pathways retrieved from the Human Pathway Database were from several sources such as Protein Lounge, BioCarta, KEGG, and NCI-Nature. The pathways were then annotated. Protein-protein relations for the most important proteins for Breast Cancer were determined by annotating the pathways and by literature review. The protein-protein interactions are mapped onto this pathway.

Ontology Tags

 

Bibliography

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History

View all...
CompareRevisionActionTimeUserComment
80445view06:02, 23 June 2015KhanspersAdded mir29b targeting of PTEN
80429view19:56, 22 June 2015KhanspersAdded additional mir21 targeting
80428view19:33, 22 June 2015KhanspersAdded mir21 targeting of BMPR2
80427view19:03, 22 June 2015KhanspersAdded mir21 targeting of PTEN
79991view19:59, 29 April 2015Zariannotated ODC1 , MYC, JUN , fra-1 , cyc-D and PPAR
72732view00:57, 4 December 2013Jakechendeleted unconnected genes.
72731view00:56, 4 December 2013Jakechenupdated DAG1
71652view19:34, 17 October 2013MaintBotUpdated data sources
70228view18:59, 15 July 2013KhanspersReverted to version '11:48, 29 June 2013' by Khanspers
70227view18:57, 15 July 2013Khanspersminor layout
68045view11:48, 29 June 2013EgonwAdded more identifiers for metabolites which were previously marked as 'unknown'.
68044view11:32, 29 June 2013EgonwAdding identifiers for metabolites which were previously marked as 'unknown'.
67397view10:55, 26 June 2013DdiglesOntology Term : 'breast cancer pathway' added !
63220view21:01, 8 May 2013MaintBotUpdating gpml version
59204view19:37, 22 February 2013MaintBotUpdated Ensembl data source
51834view19:03, 23 September 2012SaibrahiPeriodical save, work in progress
51161view21:15, 30 August 2012SaibrahiPeriodical save, work in progress
51083view19:46, 28 August 2012Pragat11Periodical save, work in progress
51082view19:36, 28 August 2012Pragat11Periodical save, work in progress
51081view19:25, 28 August 2012Pragat11Periodical save, work in progress
51020view19:18, 26 August 2012SaibrahiSpecify description
51019view19:12, 26 August 2012SaibrahiPeriodical save, work in progress
51018view19:01, 26 August 2012SaibrahiPeriodical save, work in progress
50408view17:03, 15 August 2012SaibrahiPeriodical save, work in progress
46412view16:54, 26 January 2012SaibrahiPeriodical save, work in progress
44857view09:53, 6 October 2011MartijnVanIerselOntology Term : 'breast cancer' added !
44468view20:27, 14 September 2011MaintBotModified categories
43855view13:21, 8 August 2011SaibrahiPeriodical save, work in progress
43849view19:54, 5 August 2011SaibrahiPeriodical save, work in progress
43848view19:43, 5 August 2011SaibrahiPeriodical save, work in progress
43847view19:33, 5 August 2011SaibrahiPeriodical save, work in progress
43846view19:22, 5 August 2011SaibrahiPeriodical save, work in progress
43845view18:59, 5 August 2011SaibrahiPeriodical save, work in progress
43831view14:45, 5 August 2011SaibrahiSpecify description
43830view14:37, 5 August 2011SaibrahiPeriodical save, work in progress
43829view14:26, 5 August 2011SaibrahiPeriodical save, work in progress
43828view14:16, 5 August 2011SaibrahiPeriodical save, work in progress
43827view13:55, 5 August 2011SaibrahiSpecify description
43826view13:46, 5 August 2011SaibrahiPeriodical save, work in progress
43823view13:33, 5 August 2011SaibrahiPeriodical save, work in progress
43822view13:23, 5 August 2011SaibrahiPeriodical save, work in progress
43768view20:04, 22 July 2011SaibrahiPeriodical save, work in progress
43767view19:54, 22 July 2011SaibrahiPeriodical save, work in progress
43766view19:24, 22 July 2011SaibrahiSpecify description
43765view16:00, 22 July 2011SaibrahiSpecify description
43764view15:54, 22 July 2011SaibrahiPeriodical save, work in progress
43763view15:46, 22 July 2011SaibrahiSpecify description
43754view19:35, 21 July 2011SaibrahiSpecify description
43753view19:33, 21 July 2011SaibrahiPeriodical save, work in progress
43752view19:08, 21 July 2011SaibrahiPeriodical save, work in progress

External references

View all...
NameTypeDatabase referenceComment
Cell survival and Proliferation
HIPK2ProteinQ9H2X6 (Uniprot-TrEMBL)
GR ProteinP01833 (Uniprot-TrEMBL)
CSNK1DGeneProductENSG00000141551 (Ensembl)
Cell Survival
P53ProteinP04637 (Uniprot-TrEMBL)
C9JNK1ProteinC9JNK1 (Uniprot-TrEMBL)
ATRProteinQ13535 (Uniprot-TrEMBL)
SP1GeneProductENSG00000185591 (Ensembl)
DCAKDProteinQ8WVC6 (Uniprot-TrEMBL)
CorticosteroneMetabolite5753 (PubChem-compound)
BRCA1ProteinP38398 (Uniprot-TrEMBL)
CTNB1 degradation
PMLProteinP29590 (Uniprot-TrEMBL)
FADDGeneProductENSG00000168040 (Ensembl)
PIAS1ProteinO75925 (Uniprot-TrEMBL)
ProteinProtein
HDAC1Protein
FlutamideMetabolite3397 (PubChem-compound)
SIRT1ProteinQ96EB6 (Uniprot-TrEMBL)
NCOA2GeneProductENSG00000124151 (Ensembl)
CDK2ProteinP24941 (Uniprot-TrEMBL)
Gene Expression
CDK4ProteinP11802 (Uniprot-TrEMBL)
P65 ProteinC9JP65 (Uniprot-TrEMBL)
E2F1ProteinQ01094 (Uniprot-TrEMBL)
FluoxymesteroneMetabolite6205 (Chemspider)
PTENProteinP60484 (Uniprot-TrEMBL)
Tetradecanoylphorbol AcetateMetabolite22833501 (PubChem-compound)
ATMProteinQ13315 (Uniprot-TrEMBL)
ERAL1GeneProductENSG00000132591 (Ensembl)
CHK2ProteinO96017 (Uniprot-TrEMBL) Phosphorylated
PRProteinP12270 (Uniprot-TrEMBL)
STAT1ProteinP42224 (Uniprot-TrEMBL)
BRCA2GeneProductENSG00000139618 (Ensembl)
ATF1ProteinP18846 (Uniprot-TrEMBL)
P38GeneProduct84640 (Entrez Gene)
CHK1ProteinO14757 (Uniprot-TrEMBL)
CASP8GeneProductENSG00000064012 (Ensembl)
PLK3CAGeneProduct1263 (Entrez Gene)
HDAC1/HDAC2GeneProductENSG00000116478 (Ensembl)
HDAC1ProteinQ13547 (Uniprot-TrEMBL)
CASP9GeneProductENSG00000132906 (Ensembl)
BLMProteinP54132 (Uniprot-TrEMBL)
TSC2GeneProductENSG00000103197 (Ensembl)
MSH2ProteinP43246 (Uniprot-TrEMBL)
DonepezilMetabolite3152 (PubChem-compound)
MSH6ProteinP52701 (Uniprot-TrEMBL)
CDK7GeneProduct1022 (Entrez Gene)
Q8NBS1ProteinQ8NBS1 (Uniprot-TrEMBL)
LetrozoleMetabolite3765 (Chemspider)
MRE11ProteinP49959 (Uniprot-TrEMBL)
fra-1Protein8061 (Entrez Gene)
RAD50ProteinQ92878 (Uniprot-TrEMBL)
TestosteroneMetabolite5791 (Chemspider)
BACH1ProteinO14867 (Uniprot-TrEMBL)
GRNGeneProductENSG00000030582 (Ensembl)
DAG1GeneProductENSG00000173402 (Ensembl)
Apoptosis
PKCB1ProteinQ9ULU4 (Uniprot-TrEMBL)
Cancer Development
RASGRP3GeneProductENSG00000152689 (Ensembl)
E2F1GeneProduct1869 (Entrez Gene)
KRASGeneProductENSG00000133703 (Ensembl)
IMPA1GeneProductENSG00000133731 (Ensembl)
RASGEF1AGeneProduct221002 (Entrez Gene)
NCOA3GeneProductENSG00000124151 (Ensembl)
ABC3GProteinQ9HC16 (Uniprot-TrEMBL)
JUNGeneProductENSG00000177606 (Ensembl)
RAP1AGeneProductENSG00000116473 (Ensembl)
BARD1GeneProductENSG00000138376 (Ensembl)
IPKAProteinP61925 (Uniprot-TrEMBL)
P13ProteinQ9UHV8 (Uniprot-TrEMBL)
BRAFProteinP15056 (Uniprot-TrEMBL)
MitomycinMetaboliteCHEBI:25357 (ChEBI)
MPIP1ProteinP30304 (Uniprot-TrEMBL)
HydrocortisoneMetabolite5754 (PubChem-compound)
RRASProteinP10301 (Uniprot-TrEMBL)
P85ProteinO00459 (Uniprot-TrEMBL)
SMEK2GeneProductENSG00000138041 (Ensembl)
XRCC3GeneProductENSG00000126215 (Ensembl)
CERK1ProteinQ8TCT0 (Uniprot-TrEMBL)
GCRGeneProductENSG00000113161 (Ensembl)
SELKProteinQ9Y6D0 (Uniprot-TrEMBL)
FOXO1GeneProductENSG00000150907 (Ensembl)
NF1ProteinP21359 (Uniprot-TrEMBL)
BleomycinMetabolite456190 (PubChem-compound)
RAC1ProteinP63000 (Uniprot-TrEMBL)
NFKB1 ProteinP19838 (Uniprot-TrEMBL)
RALGAPA1GeneProductENSG00000174373 (Ensembl)
MTORGeneProductENSG00000198793 (Ensembl)
RALAProteinP11233 (Uniprot-TrEMBL)
Anti-Apoptosis
RHOGeneProduct6010 (Entrez Gene)
MPIP2 ProteinP30305 (Uniprot-TrEMBL)
CDC42GeneProductENSG00000070831 (Ensembl)
AHRGeneProductENSG00000106546 (Ensembl)
ALKB1ProteinQ13686 (Uniprot-TrEMBL)
AmpicillinMetabolite6249 (PubChem-compound)
TSC1ProteinQ92574 (Uniprot-TrEMBL)
CYP19A1GeneProductENSG00000137869 (Ensembl)
RHEBProteinQ15382 (Uniprot-TrEMBL)
ODC1Protein4953 (Entrez Gene)
AKT1ProteinP31749 (Uniprot-TrEMBL)
MYCProtein4609 (Entrez Gene)
GSK3AProteinP49840 (Uniprot-TrEMBL)
PPARProtein8061 (Entrez Gene)
CCND1ProteinP24385 (Uniprot-TrEMBL)
LapatnibMetabolite208908 (PubChem-compound)
MDM2ProteinQ00987 (Uniprot-TrEMBL)
MIR29B1RnaENSG00000207748 (Ensembl)
NOXA1ProteinQ86UR1 (Uniprot-TrEMBL)
CycloheximideMetabolite6197 (PubChem-compound)
BADProteinQ92934 (Uniprot-TrEMBL)
DexamethasoneMetabolite5743 (PubChem-compound)
PAK1ProteinQ13153 (Uniprot-TrEMBL)
ITPKCGeneProductENSG00000086544 (Ensembl)
BCL2ProteinP10415 (Uniprot-TrEMBL)
TamoxifenMetabolite2733526 (PubChem-compound)
UBIMProteinP35544 (Uniprot-TrEMBL)
Cell Cycle arrest
MMP1ProteinP03956 (Uniprot-TrEMBL)
EstradiolMetabolite5757 (PubChem-compound)
BAKProteinQ16611 (Uniprot-TrEMBL)
P13KGeneProductENSG00000229882 (Ensembl)
PPRB/RBProteinP06400 (Uniprot-TrEMBL)
ERProteinP16591 (Uniprot-TrEMBL)
WEE1ProteinP30291 (Uniprot-TrEMBL)
ARProteinQ9UNE0 (Uniprot-TrEMBL)
CDC25AGeneProduct993 (Entrez Gene)
DHTGeneProductENSG00000181192 (Ensembl)
NAB1ProteinQ13506 (Uniprot-TrEMBL)
DihydrotestosteroneMetaboliteHMDB02961 (HMDB)
RAD51ProteinQ06609 (Uniprot-TrEMBL)
Transcription
SMAD4ProteinQ13485 (Uniprot-TrEMBL)
ESR1GeneProductENSG00000091831 (Ensembl)
UBE2FProteinQ969M7 (Uniprot-TrEMBL)
Cell proliferation
SMAD2ProteinQ15796 (Uniprot-TrEMBL)
RAD54LGeneProductENSG00000085999 (Ensembl)
MYCProteinP01106 (Uniprot-TrEMBL)
SMCA4ProteinP51532 (Uniprot-TrEMBL)
MAXProteinP61244 (Uniprot-TrEMBL)
MAPKsGeneProduct5594 (Entrez Gene)
ZMIZ1ProteinQ9ULJ6 (Uniprot-TrEMBL)
ERKGeneProduct64781 (Entrez Gene)
BMPR1AGeneProductENSG00000107779 (Ensembl)
NocodazoleMetabolite4122 (PubChem-compound)
BMPR2ProteinQ13873 (Uniprot-TrEMBL)
HydroxyureaMetabolite3657 (PubChem-compound)
SMAD7ProteinO15105 (Uniprot-TrEMBL)
ANDRProteinP10275 (Uniprot-TrEMBL)
SMAD1ProteinQ15797 (Uniprot-TrEMBL)
GDIGeneProduct2664 (Entrez Gene)
SMAD3ProteinQ13485 (Uniprot-TrEMBL)
CASP3GeneProductENSG00000164305 (Ensembl)
SMAD6ProteinO43541 (Uniprot-TrEMBL)
ABL1GeneProductENSG00000097007 (Ensembl)
SMAD4ProteinQ15796 (Uniprot-TrEMBL)
CBPGeneProductENSG00000005810 (Ensembl)
TGFR1ProteinP36897 (Uniprot-TrEMBL)
TFPIGeneProductENSG00000003436 (Ensembl)
TGFR2ProteinP37173 (Uniprot-TrEMBL)
P85AGeneProductENSG00000125450 (Ensembl)
TAK1LProteinP57077 (Uniprot-TrEMBL)
PLK3GeneProductENSG00000173846 (Ensembl)
TAB1ProteinQ15750 (Uniprot-TrEMBL)
CREBGeneProductENSG00000118260 (Ensembl)
RPP38GeneProductENSG00000152464 (Ensembl)
IRS1GeneProductENSG00000169047 (Ensembl)
CIP1ProteinQ9NPC3 (Uniprot-TrEMBL)
Methyl MethanesulfonateMetabolite4156 (PubChem-compound)
JKIP1ProteinQ96N16 (Uniprot-TrEMBL)
PlicamycinMetabolite457831 (PubChem-compound)
UBP15ProteinQ9Y4E8 (Uniprot-TrEMBL)
BARD1GeneProduct580 (Entrez Gene)
UBP16ProteinQ9Y5T5 (Uniprot-TrEMBL)
TSC1GeneProductENSG00000165699 (Ensembl)
FADDProteinQ13158 (Uniprot-TrEMBL)
STK11GeneProductENSG00000118046 (Ensembl)
TRADDProteinQ15628 (Uniprot-TrEMBL)
CDH1GeneProductENSG00000039068 (Ensembl)
FLIP1ProteinQ7Z7B0 (Uniprot-TrEMBL)
PHBGeneProductENSG00000167085 (Ensembl)
BIDProteinP55957 (Uniprot-TrEMBL)
EP300GeneProductENSG00000100393 (Ensembl)
UBP21ProteinQ9UK80 (Uniprot-TrEMBL)
CTNB1ProteinP35222 (Uniprot-TrEMBL)
B5MEC1ProteinB5MEC1 (Uniprot-TrEMBL)
Lithium ChlorideMetabolite433294 (PubChem-compound)
EGFRProteinP00533 (Uniprot-TrEMBL)
ANXA1GeneProductENSG00000135046 (Ensembl)
JAK1ProteinP23458 (Uniprot-TrEMBL)
RHOGeneProductENSG00000163914 (Ensembl)
DNA
AURKAGeneProductENSG00000087586 (Ensembl)
VEGFAGeneProductENSG00000112715 (Ensembl)
Penicillin GMetabolite5693 (Chemspider)
Angiogenesis
RaloxifeneMetabolite4859 (Chemspider)
Proliferative genes
Exemstane
CERKGeneProduct64781 (Entrez Gene)
AnastrozoleMetabolite2102 (Chemspider)
SMEK1GeneProductENSG00000100796 (Ensembl)
Proteasome
IKKAProteinO15111 (Uniprot-TrEMBL)
TCF/LEFProtein
B3KP27ProteinB3KP27 (Uniprot-TrEMBL)
JUNProtein3725 (Entrez Gene)
RAFProteinP10398 (Uniprot-TrEMBL)
cyc-DProtein
AQP73ProteinA6NL99 (Uniprot-TrEMBL)
Conjugated Estrogens
GADD45AGeneProductENSG00000116717 (Ensembl)
FulvestrantMetabolite104741 (PubChem-compound)
MYT1ProteinQ01538 (Uniprot-TrEMBL)
PaclitaxelMetabolite10368587 (Chemspider)
PLK1ProteinP53350 (Uniprot-TrEMBL)
MIR21RnaENSG00000199004 (Ensembl)
BAXGeneProductENSG00000087088 (Ensembl)
MIR29B2RnaENSG00000207790 (Ensembl)
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