Integrated Breast Cancer Pathway (Homo sapiens)

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Curation Tags

Description

This pathway incorporates the most important proteins for Breast Cancer. The Rp score from the Connectivity-Maps (C-Maps) webserver was used to determine the rank of the most important proteins in Breast Cancer. These proteins were then used to determine the most important pathways involved in Breast Cancer by using the Human Pathway Database (HPD). The pathways retrieved from the Human Pathway Database were from several sources such as Protein Lounge, BioCarta, KEGG, and NCI-Nature. The pathways were then annotated. Protein-protein relations for the most important proteins for Breast Cancer were determined by annotating the pathways and by literature review. The protein-protein interactions are mapped onto this pathway.

Ontology Tags

 

Bibliography

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  1. Zhang H, Shi X, Zhang QJ, Hampong M, Paddon H, Wahyuningsih D, Pelech S; ''Nocodazole-induced p53-dependent c-Jun N-terminal kinase activation reduces apoptosis in human colon carcinoma HCT116 cells.''; J Biol Chem, 2002 PubMed
  2. Horton JK, Stefanick DF, Naron JM, Kedar PS, Wilson SH; ''Poly(ADP-ribose) polymerase activity prevents signaling pathways for cell cycle arrest after DNA methylating agent exposure.''; J Biol Chem, 2005 PubMed
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History

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CompareRevisionActionTimeUserComment
72732view00:57, 4 December 2013Jakechendeleted unconnected genes.
72731view00:56, 4 December 2013Jakechenupdated DAG1
71652view19:34, 17 October 2013MaintBotUpdated data sources
70228view18:59, 15 July 2013KhanspersReverted to version '11:48, 29 June 2013' by Khanspers
70227view18:57, 15 July 2013Khanspersminor layout
68045view11:48, 29 June 2013EgonwAdded more identifiers for metabolites which were previously marked as 'unknown'.
68044view11:32, 29 June 2013EgonwAdding identifiers for metabolites which were previously marked as 'unknown'.
67397view10:55, 26 June 2013DdiglesOntology Term : 'breast cancer pathway' added !
63220view21:01, 8 May 2013MaintBotUpdating gpml version
59204view19:37, 22 February 2013MaintBotUpdated Ensembl data source
51834view19:03, 23 September 2012SaibrahiPeriodical save, work in progress
51161view21:15, 30 August 2012SaibrahiPeriodical save, work in progress
51083view19:46, 28 August 2012Pragat11Periodical save, work in progress
51082view19:36, 28 August 2012Pragat11Periodical save, work in progress
51081view19:25, 28 August 2012Pragat11Periodical save, work in progress
51020view19:18, 26 August 2012SaibrahiSpecify description
51019view19:12, 26 August 2012SaibrahiPeriodical save, work in progress
51018view19:01, 26 August 2012SaibrahiPeriodical save, work in progress
50408view17:03, 15 August 2012SaibrahiPeriodical save, work in progress
46412view16:54, 26 January 2012SaibrahiPeriodical save, work in progress
44857view09:53, 6 October 2011MartijnVanIerselOntology Term : 'breast cancer' added !
44468view20:27, 14 September 2011MaintBotModified categories
43855view13:21, 8 August 2011SaibrahiPeriodical save, work in progress
43849view19:54, 5 August 2011SaibrahiPeriodical save, work in progress
43848view19:43, 5 August 2011SaibrahiPeriodical save, work in progress
43847view19:33, 5 August 2011SaibrahiPeriodical save, work in progress
43846view19:22, 5 August 2011SaibrahiPeriodical save, work in progress
43845view18:59, 5 August 2011SaibrahiPeriodical save, work in progress
43831view14:45, 5 August 2011SaibrahiSpecify description
43830view14:37, 5 August 2011SaibrahiPeriodical save, work in progress
43829view14:26, 5 August 2011SaibrahiPeriodical save, work in progress
43828view14:16, 5 August 2011SaibrahiPeriodical save, work in progress
43827view13:55, 5 August 2011SaibrahiSpecify description
43826view13:46, 5 August 2011SaibrahiPeriodical save, work in progress
43823view13:33, 5 August 2011SaibrahiPeriodical save, work in progress
43822view13:23, 5 August 2011SaibrahiPeriodical save, work in progress
43768view20:04, 22 July 2011SaibrahiPeriodical save, work in progress
43767view19:54, 22 July 2011SaibrahiPeriodical save, work in progress
43766view19:24, 22 July 2011SaibrahiSpecify description
43765view16:00, 22 July 2011SaibrahiSpecify description
43764view15:54, 22 July 2011SaibrahiPeriodical save, work in progress
43763view15:46, 22 July 2011SaibrahiSpecify description
43754view19:35, 21 July 2011SaibrahiSpecify description
43753view19:33, 21 July 2011SaibrahiPeriodical save, work in progress
43752view19:08, 21 July 2011SaibrahiPeriodical save, work in progress
43751view18:38, 21 July 2011SaibrahiPeriodical save, work in progress
43750view18:18, 21 July 2011SaibrahiPeriodical save, work in progress
43749view18:07, 21 July 2011SaibrahiPeriodical save, work in progress
43748view17:47, 21 July 2011SaibrahiPeriodical save, work in progress
43700view18:07, 15 July 2011SaibrahiSpecify description

External references

View all...
NameTypeDatabase referenceComment
ERProteinP16591 (Uniprot-TrEMBL)
Lithium ChlorideMetabolite433294 (PubChem-compound)
HIPK2ProteinQ9H2X6 (Uniprot-TrEMBL)
ABL1GeneProductENSG00000097007 (Ensembl)
CSNK1DGeneProductENSG00000141551 (Ensembl)
PLK1ProteinP53350 (Uniprot-TrEMBL)
P53ProteinP04637 (Uniprot-TrEMBL)
SMCA4ProteinP51532 (Uniprot-TrEMBL)
ATRProteinQ13535 (Uniprot-TrEMBL)
PlicamycinMetabolite457831 (PubChem-compound)
DCAKDProteinQ8WVC6 (Uniprot-TrEMBL)
Proteasome
BRCA1ProteinP38398 (Uniprot-TrEMBL)
TamoxifenMetabolite2733526 (PubChem-compound)
PMLProteinP29590 (Uniprot-TrEMBL)
Transcription
PIAS1ProteinO75925 (Uniprot-TrEMBL)
HydroxyureaMetabolite3657 (PubChem-compound)
HDAC1Protein
PLK3GeneProductENSG00000173846 (Ensembl)
SIRT1ProteinQ96EB6 (Uniprot-TrEMBL)
CDH1GeneProductENSG00000039068 (Ensembl)
CDK2ProteinP24941 (Uniprot-TrEMBL)
Penicillin GMetabolite5693 (Chemspider)
CDK4ProteinP11802 (Uniprot-TrEMBL)
Conjugated Estrogens
E2F1ProteinQ01094 (Uniprot-TrEMBL)
DexamethasoneMetabolite5743 (PubChem-compound)
PTENProteinP60484 (Uniprot-TrEMBL)
EstradiolMetabolite5757 (PubChem-compound)
ATMProteinQ13315 (Uniprot-TrEMBL)
DHTGeneProductENSG00000181192 (Ensembl)
CHK2ProteinO96017 (Uniprot-TrEMBL) Phosphorylated
Cell proliferation
STAT1ProteinP42224 (Uniprot-TrEMBL)
ERKGeneProduct64781 (Entrez Gene)
ATF1ProteinP18846 (Uniprot-TrEMBL)
GDIGeneProduct2664 (Entrez Gene)
CHK1ProteinO14757 (Uniprot-TrEMBL)
TFPIGeneProductENSG00000003436 (Ensembl)
PLK3CAGeneProduct1263 (Entrez Gene)
IRS1GeneProductENSG00000169047 (Ensembl)
HDAC1ProteinQ13547 (Uniprot-TrEMBL)
TSC1GeneProductENSG00000165699 (Ensembl)
BLMProteinP54132 (Uniprot-TrEMBL)
EP300GeneProductENSG00000100393 (Ensembl)
MSH2ProteinP43246 (Uniprot-TrEMBL)
RHOGeneProductENSG00000163914 (Ensembl)
MSH6ProteinP52701 (Uniprot-TrEMBL)
Exemstane
Q8NBS1ProteinQ8NBS1 (Uniprot-TrEMBL)
JUNProtein
MRE11ProteinP49959 (Uniprot-TrEMBL)
PaclitaxelMetabolite10368587 (Chemspider)
RAD50ProteinQ92878 (Uniprot-TrEMBL)
CycloheximideMetabolite6197 (PubChem-compound)
BACH1ProteinO14867 (Uniprot-TrEMBL)
ITPKCGeneProductENSG00000086544 (Ensembl)
DAG1GeneProductENSG00000173402 (Ensembl)
Cell Cycle arrest
PKCB1ProteinQ9ULU4 (Uniprot-TrEMBL)
P13KGeneProductENSG00000229882 (Ensembl)
RASGRP3GeneProductENSG00000152689 (Ensembl)
ARProteinQ9UNE0 (Uniprot-TrEMBL)
KRASGeneProductENSG00000133703 (Ensembl)
DihydrotestosteroneMetaboliteHMDB02961 (HMDB)
RASGEF1AGeneProduct221002 (Entrez Gene)
ESR1GeneProductENSG00000091831 (Ensembl)
ABC3GProteinQ9HC16 (Uniprot-TrEMBL)
RAD54LGeneProductENSG00000085999 (Ensembl)
RAP1AGeneProductENSG00000116473 (Ensembl)
MAPKsGeneProduct5594 (Entrez Gene)
IPKAProteinP61925 (Uniprot-TrEMBL)
NocodazoleMetabolite4122 (PubChem-compound)
BRAFProteinP15056 (Uniprot-TrEMBL)
ANDRProteinP10275 (Uniprot-TrEMBL)
MPIP1ProteinP30304 (Uniprot-TrEMBL)
CASP3GeneProductENSG00000164305 (Ensembl)
RRASProteinP10301 (Uniprot-TrEMBL)
CBPGeneProductENSG00000005810 (Ensembl)
SMEK2GeneProductENSG00000138041 (Ensembl)
P85AGeneProductENSG00000125450 (Ensembl)
CERK1ProteinQ8TCT0 (Uniprot-TrEMBL)
CREBGeneProductENSG00000118260 (Ensembl)
SELKProteinQ9Y6D0 (Uniprot-TrEMBL)
Methyl MethanesulfonateMetabolite4156 (PubChem-compound)
NF1ProteinP21359 (Uniprot-TrEMBL)
BARD1GeneProduct580 (Entrez Gene)
RAC1ProteinP63000 (Uniprot-TrEMBL)
STK11GeneProductENSG00000118046 (Ensembl)
RALGAPA1GeneProductENSG00000174373 (Ensembl)
PHBGeneProductENSG00000167085 (Ensembl)
RALAProteinP11233 (Uniprot-TrEMBL)
CTNB1ProteinP35222 (Uniprot-TrEMBL)
RHOGeneProduct6010 (Entrez Gene)
ANXA1GeneProductENSG00000135046 (Ensembl)
CDC42GeneProductENSG00000070831 (Ensembl)
AURKAGeneProductENSG00000087586 (Ensembl)
ALKB1ProteinQ13686 (Uniprot-TrEMBL)
RaloxifeneMetabolite4859 (Chemspider)
TSC1ProteinQ92574 (Uniprot-TrEMBL)
AnastrozoleMetabolite2102 (Chemspider)
RHEBProteinQ15382 (Uniprot-TrEMBL)
TCF/LEFProtein
AKT1ProteinP31749 (Uniprot-TrEMBL)
cyc-DProtein
GSK3AProteinP49840 (Uniprot-TrEMBL)
FulvestrantMetabolite104741 (PubChem-compound)
CCND1ProteinP24385 (Uniprot-TrEMBL)
C9JNK1ProteinC9JNK1 (Uniprot-TrEMBL)
MDM2ProteinQ00987 (Uniprot-TrEMBL)
BAXGeneProductENSG00000087088 (Ensembl)
NOXA1ProteinQ86UR1 (Uniprot-TrEMBL)
GRNGeneProductENSG00000030582 (Ensembl)
BADProteinQ92934 (Uniprot-TrEMBL)
Tetradecanoylphorbol AcetateMetabolite22833501 (PubChem-compound)
PAK1ProteinQ13153 (Uniprot-TrEMBL)
Apoptosis
BCL2ProteinP10415 (Uniprot-TrEMBL)
FADDGeneProductENSG00000168040 (Ensembl)
UBIMProteinP35544 (Uniprot-TrEMBL)
Cancer Development
MMP1ProteinP03956 (Uniprot-TrEMBL)
ERAL1GeneProductENSG00000132591 (Ensembl)
BAKProteinQ16611 (Uniprot-TrEMBL)
E2F1GeneProduct1869 (Entrez Gene)
PPRB/RBProteinP06400 (Uniprot-TrEMBL)
Cell survival and Proliferation
WEE1ProteinP30291 (Uniprot-TrEMBL)
IMPA1GeneProductENSG00000133731 (Ensembl)
CDC25AGeneProduct993 (Entrez Gene)
PRProteinP12270 (Uniprot-TrEMBL)
NAB1ProteinQ13506 (Uniprot-TrEMBL)
NCOA3GeneProductENSG00000124151 (Ensembl)
RAD51ProteinQ06609 (Uniprot-TrEMBL)
ProteinProtein
SMAD4ProteinQ13485 (Uniprot-TrEMBL)
JUNGeneProductENSG00000177606 (Ensembl)
UBE2FProteinQ969M7 (Uniprot-TrEMBL)
BRCA2GeneProductENSG00000139618 (Ensembl)
SMAD2ProteinQ15796 (Uniprot-TrEMBL)
BARD1GeneProductENSG00000138376 (Ensembl)
MYCProteinP01106 (Uniprot-TrEMBL)
SP1GeneProductENSG00000185591 (Ensembl)
MAXProteinP61244 (Uniprot-TrEMBL)
P13ProteinQ9UHV8 (Uniprot-TrEMBL)
ZMIZ1ProteinQ9ULJ6 (Uniprot-TrEMBL)
P38GeneProduct84640 (Entrez Gene)
BMPR1AGeneProductENSG00000107779 (Ensembl)
MitomycinMetaboliteCHEBI:25357 (ChEBI)
BMPR2ProteinQ13873 (Uniprot-TrEMBL)
FlutamideMetabolite3397 (PubChem-compound)
SMAD7ProteinO15105 (Uniprot-TrEMBL)
HydrocortisoneMetabolite5754 (PubChem-compound)
SMAD1ProteinQ15797 (Uniprot-TrEMBL)
CASP8GeneProductENSG00000064012 (Ensembl)
SMAD3ProteinQ13485 (Uniprot-TrEMBL)
P85ProteinO00459 (Uniprot-TrEMBL)
SMAD6ProteinO43541 (Uniprot-TrEMBL)
Cell Survival
SMAD4ProteinQ15796 (Uniprot-TrEMBL)
XRCC3GeneProductENSG00000126215 (Ensembl)
TGFR1ProteinP36897 (Uniprot-TrEMBL)
HDAC1/HDAC2GeneProductENSG00000116478 (Ensembl)
TGFR2ProteinP37173 (Uniprot-TrEMBL)
GCRGeneProductENSG00000113161 (Ensembl)
TAK1LProteinP57077 (Uniprot-TrEMBL)
NCOA2GeneProductENSG00000124151 (Ensembl)
TAB1ProteinQ15750 (Uniprot-TrEMBL)
FOXO1GeneProductENSG00000150907 (Ensembl)
RPP38GeneProductENSG00000152464 (Ensembl)
CASP9GeneProductENSG00000132906 (Ensembl)
CIP1ProteinQ9NPC3 (Uniprot-TrEMBL)
BleomycinMetabolite456190 (PubChem-compound)
JKIP1ProteinQ96N16 (Uniprot-TrEMBL)
CorticosteroneMetabolite5753 (PubChem-compound)
UBP15ProteinQ9Y4E8 (Uniprot-TrEMBL)
NFKB1 ProteinP19838 (Uniprot-TrEMBL)
UBP16ProteinQ9Y5T5 (Uniprot-TrEMBL)
TSC2GeneProductENSG00000103197 (Ensembl)
FADDProteinQ13158 (Uniprot-TrEMBL)
MTORGeneProductENSG00000198793 (Ensembl)
TRADDProteinQ15628 (Uniprot-TrEMBL)
Gene Expression
FLIP1ProteinQ7Z7B0 (Uniprot-TrEMBL)
Anti-Apoptosis
BIDProteinP55957 (Uniprot-TrEMBL)
DonepezilMetabolite3152 (PubChem-compound)
UBP21ProteinQ9UK80 (Uniprot-TrEMBL)
MPIP2 ProteinP30305 (Uniprot-TrEMBL)
B5MEC1ProteinB5MEC1 (Uniprot-TrEMBL)
GR ProteinP01833 (Uniprot-TrEMBL)
EGFRProteinP00533 (Uniprot-TrEMBL)
AHRGeneProductENSG00000106546 (Ensembl)
JAK1ProteinP23458 (Uniprot-TrEMBL)
CDK7GeneProduct1022 (Entrez Gene)
DNA
AmpicillinMetabolite6249 (PubChem-compound)
VEGFAGeneProductENSG00000112715 (Ensembl)
P65 ProteinC9JP65 (Uniprot-TrEMBL)
Angiogenesis
CYP19A1GeneProductENSG00000137869 (Ensembl)
Proliferative genes
LetrozoleMetabolite3765 (Chemspider)
CERKGeneProduct64781 (Entrez Gene)
ODC1Protein
SMEK1GeneProductENSG00000100796 (Ensembl)
CTNB1 degradation
IKKAProteinO15111 (Uniprot-TrEMBL)
MYCProtein
B3KP27ProteinB3KP27 (Uniprot-TrEMBL)
fra-1Protein
RAFProteinP10398 (Uniprot-TrEMBL)
PPARProtein
AQP73ProteinA6NL99 (Uniprot-TrEMBL)
FluoxymesteroneMetabolite6205 (Chemspider)
GADD45AGeneProductENSG00000116717 (Ensembl)
LapatnibMetabolite208908 (PubChem-compound)
MYT1ProteinQ01538 (Uniprot-TrEMBL)
TestosteroneMetabolite5791 (Chemspider)
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