SREBP signalling (Homo sapiens)

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Description

Sterol regulatory element-binding proteins (SREBPs) are membrane-bound proteins that act as transcription factors. They regulate lipid, especially cholesterol, biosynthesis and uptake at a transcriptional level to maintain cellular lipid homeostasis. In addition, SREBP appears to be involved in a variety of other cellular processes. This pathway of SREBP focusses on the regulation of lipid metabolism by SREBP. The data on which this pathway is based, is derived from a variety of in vitro and in vivo studies using different species, including mouse, rat, hamster and human. This pathway served as the basis for a review about SREBP that was published in Genes and Nutrition: PubMed.

Ontology Tags

 

Bibliography

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History

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CompareRevisionActionTimeUserComment
73382view05:26, 25 January 2014MaintBotremoved newlines from datanode labels
71987view11:08, 24 October 2013MkutmonChanged Unknown -> RNA for miRNA33a
71698view19:46, 17 October 2013MaintBotUpdated UniProt/TrEMBL data source
68403view09:40, 5 July 2013EveloModified description
68402view09:39, 5 July 2013EveloModified description
68401view09:32, 5 July 2013EveloAdded reference for review paper.
67653view11:44, 26 June 2013DdiglesOntology Term : 'sterol regulatory element-binding protein signaling pathway' added !
63160view20:19, 8 May 2013MaintBotUpdating gpml version
59430view09:37, 27 February 2013SabinedaemenModified description
59171view18:35, 22 February 2013MaintBotUpdated Ensembl data source
58748view12:15, 20 February 2013Sabinedaemenannotations
58745view09:56, 20 February 2013Sabinedaemenannotations
58744view09:52, 20 February 2013Sabinedaemenannotations
58743view09:01, 20 February 2013Sabinedaemenannotations
58578view10:43, 16 February 2013SabinedaemenModified description
58567view16:25, 15 February 2013Sabinedaemenliterature added
58566view16:21, 15 February 2013Sabinedaemenupdate
58565view10:58, 15 February 2013SabinedaemenRBP4
58564view08:59, 15 February 2013SabinedaemenFGF21
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External references

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NameTypeDatabase referenceComment
LPLGeneProductENSG00000175445 (Ensembl)
SCAPGeneProductENSG00000114650 (Ensembl)
S2PGeneProductENSG00000012174 (Ensembl)
INSIG1GeneProductENSG00000186480 (Ensembl)
SEC24AGeneProductENSG00000113615 (Ensembl)
nSREBPGeneProductENSG00000072310 (Ensembl)
LSSGeneProductENSG00000160285 (Ensembl)
S1PGeneProductENSG00000140943 (Ensembl)
MDHGeneProductENSG00000014641 (Ensembl)
OxysterolsMetaboliteCHEBI:53030 (ChEBI)
SEC13GeneProductENSG00000157020 (Ensembl)
CholesterolMetaboliteHMDB00067 (HMDB)
SP1GeneProductENSG00000185591 (Ensembl)
importin betaGeneProductENSG00000108424 (Ensembl)
FDPSGeneProductENSG00000160752 (Ensembl)
NFYGeneProductENSG00000001167 (Ensembl)
GPAGeneProductENSG00000119927 (Ensembl)
InsulinProteinP01308 (Uniprot-TrEMBL)
SREBP2GeneProductENSG00000198911 (Ensembl)
PUFAsMetaboliteCHEBI:26208 (ChEBI) Inhibition of SREBP1 processing
SEC24CGeneProductENSG00000176986 (Ensembl)
TRC8GeneProductENSG00000170881 (Ensembl)
SEC31BGeneProductENSG00000075826 (Ensembl)
LXRGeneProductENSG00000131408 (Ensembl)
nSREBP2GeneProductENSG00000198911 (Ensembl)
GlucoseMetaboliteHMDB00122 (HMDB)
PGC-1betaGeneProductENSG00000155846 (Ensembl)
ATF6GeneProductENSG00000118217 (Ensembl)
MVDGeneProductENSG00000167508 (Ensembl)
GlutamineMetaboliteHMDB00641 (HMDB)
SQLEGeneProductENSG00000104549 (Ensembl)
GSK3GeneProductENSG00000105723 (Ensembl)
SCARB1GeneProductENSG00000073060 (Ensembl)
HMGCRGeneProductENSG00000113161 (Ensembl)
DBIGeneProductENSG00000155368 (Ensembl)
mTORC1GeneProductENSG00000198793 (Ensembl)
ACSGeneProductENSG00000154930 (Ensembl)
miRNA33aRnaMI0000091 (miRBase Sequence)
SEC23BGeneProductENSG00000101310 (Ensembl)
miRNA33bRnaMI0003646 (miRBase Sequence)
SEC24BGeneProductENSG00000138802 (Ensembl)
PI3KGeneProductENSG00000121879 (Ensembl)
SEC24DGeneProductENSG00000150961 (Ensembl)
AKTGeneProductENSG00000142208 (Ensembl)
SEC31AGeneProductENSG00000138674 (Ensembl)
LPIN1GeneProductENSG00000134324 (Ensembl)
SREBF2GeneProductENSG00000198911 (Ensembl)
CDK8GeneProductENSG00000132964 (Ensembl)
nSREBP1a,-cGeneProductENSG00000072310 (Ensembl)
UFAsMetaboliteCHEBI:26208 (ChEBI)
CREBGeneProductENSG00000118260 (Ensembl)
SIRT1GeneProductENSG00000096717 (Ensembl)
YY1GeneProductENSG00000100811 (Ensembl)
AMPKGeneProductENSG00000249325 (Ensembl)
ARC105GeneProductENSG00000099917 (Ensembl) activator recruited cofactor (ARC)-mediator activator complex
FGF21GeneProductENSG00000105550 (Ensembl)
HMGCSGeneProductENSG00000112972 (Ensembl)
RBP4GeneProductENSG00000138207 (Ensembl)
IDIGeneProductENSG00000067064 (Ensembl)
gp78GeneProductENSG00000159461 (Ensembl)
FDFTGeneProductENSG00000079459 (Ensembl)
PKAGeneProductENSG00000072062 (Ensembl)
CYP51A1GeneProductENSG00000001630 (Ensembl)
CAMPGeneProductENSG00000164047 (Ensembl)
LDLRGeneProductENSG00000130164 (Ensembl)
INSIG2GeneProductENSG00000125629 (Ensembl)
ACACAGeneProductENSG00000132142 (Ensembl)
SREBP1a,-cGeneProductENSG00000072310 (Ensembl)
FASNGeneProductENSG00000169710 (Ensembl)
SAR1AGeneProductENSG00000079332 (Ensembl)
ACLYGeneProductENSG00000131473 (Ensembl)
SAR1BGeneProductENSG00000152700 (Ensembl)
PPARGGeneProductENSG00000132170 (Ensembl)
SEC23AGeneProductENSG00000100934 (Ensembl)
SCDGeneProductENSG00000099194 (Ensembl)
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