Cholesterol Biosynthesis (Homo sapiens)

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Curation Tags

Description

Cholesterol is a waxy steroid metabolite found in the cell membranes and transported in the blood plasma of all animals. It is an essential structural component of mammalian cell membranes, where it is required to establish proper membrane permeability and fluidity. In addition, cholesterol is an important component for the manufacture of bile acids, steroid hormones, and several fat-soluble vitamins. Cholesterol is the principal sterol synthesized by animals, but small quantities are synthesized in other eukaryotes, such as plants and fungi. It is almost completely absent among prokaryotes, which include bacteria. Source: Wikipedia

Ontology Tags

 

Bibliography

View all 7 references
  1. Bard M, Bruner DA, Pierson CA, Lees ND, Biermann B, Frye L, Koegel C, Barbuch R; ''Cloning and characterization of ERG25, the Saccharomyces cerevisiae gene encoding C-4 sterol methyl oxidase.; ''Proc Natl Acad Sci U S A, 1996 - PubMed
  2. Sagami H, Korenaga T, Ogura K; ''Geranylgeranyl diphosphate synthase catalyzing the single condensation between isopentenyl diphosphate and farnesyl diphosphate.; ''J Biochem, 1993 - PubMed
  3. Liu XY, Dangel AW, Kelley RI, Zhao W, Denny P, Botcherby M, Cattanach B, Peters J, Hunsicker PR, Mallon AM, Strivens MA, Bate R, Miller W, Rhodes M, Brown SD, Herman GE; ''The gene mutated in bare patches and striated mice encodes a novel 3beta-hydroxysteroid dehydrogenase.; ''Nat Genet, 1999 - PubMed
  4. Ohashi M, Mizushima N, Kabeya Y, Yoshimori T; ''Localization of mammalian NAD(P)H steroid dehydrogenase-like protein on lipid droplets.; ''J Biol Chem, 2003 - PubMed
  5. Gaylor JL; ''Membrane-bound enzymes of cholesterol synthesis from lanosterol.; ''Biochem Biophys Res Commun, 2002 - PubMed
  6. Li L, Kaplan J; ''Characterization of yeast methyl sterol oxidase (ERG25) and identification of a human homologue.; ''J Biol Chem, 1996 - PubMed
  7. Noshiro M, Aoyama Y, Kawamoto T, Gotoh O, Horiuchi T, Yoshida Y; ''Structural and evolutionary studies on sterol 14-demethylase P450 (CYP51), the most conserved P450 monooxygenase: I. Structural analyses of the gene and multiple sizes of mRNA.; ''J Biochem, 1997 - PubMed

Categories


History

View all
CompareRevisionActionTimeUserComment
44991view14:36, 6 October 2011MartijnVanIerselOntology Term : 'cholesterol biosynthetic pathway' added !
43562view21:55, 29 June 2011Samuel SklarSREBP added
41229view23:46, 1 March 2011MaintBotRemoved redundant pathway information and comments
35133view13:55, 11 February 2010ThomasModified description
35132view13:53, 11 February 2010Thomasremoved genmapp comments
35131view13:52, 11 February 2010Thomasadded references
34473view18:34, 10 December 2009MaintBotAutomatic update of empty xrefs
31995view13:15, 14 August 2009MaintBotFixed group labels
21093view11:30, 14 November 2008MaintBot[[Pathway:Homo sapiens:Cholesterol Biosynthesis]] moved to [[Pathway:WP197]]: Moved to stable identifier
14362view15:13, 22 May 2008Pahlesfor some metabolites the type was unknown
14346view13:51, 22 May 2008Pahlesreactions connected
14344view13:40, 22 May 2008PahlesPeriodical save, work in progress
14338view13:29, 22 May 2008Pahlesmetabolites added
14336view13:28, 22 May 2008PahlesPeriodical save, work in progress
14329view13:18, 22 May 2008PahlesPeriodical save, work in progress
14324view13:08, 22 May 2008PahlesPeriodical save, work in progress
14318view12:57, 22 May 2008PahlesPeriodical save, work in progress
13048view11:11, 17 May 2008MaintBotautomated metabolite conversion
7954view13:46, 7 January 2008MaintBot[[Pathway:Human:Cholesterol Biosynthesis]] moved to [[Pathway:Homo sapiens:Cholesterol Biosynthesis]]: Renaming species
7601view16:03, 18 December 2007MaintBotfixed category names
7334view12:42, 4 November 2007MaintBotAdded categories to GPML
19405view22:17, 22 May 2007N.Manteigpml file for [[Human:Cholesterol_Biosynthesis]]
6302view22:17, 22 May 2007M.Liebermangpml file for [[Human:Cholesterol_Biosynthesis]]

External references

View all 32...

Name Type Database reference
SREBF1GeneProductENSG00000072310 (Ensembl Human)
Mevalonic acid 5-pyrophosphateMetabolite1492-08-6 (CAS)
IDI1GeneProduct3422 (Entrez Gene)
CholesterolMetabolite57-88-5 (CAS)
HMGCS1GeneProduct3157 (Entrez Gene)
7-DehydrocholesterolMetabolite434-16-2 (CAS)
HMGCRGeneProduct3156 (Entrez Gene)
SqualeneMetabolite111-02-4 (CAS)
MVKGeneProduct4598 (Entrez Gene)
Mevalonic acidMetabolite150-97-0 (CAS)
MVDGeneProduct4597 (Entrez Gene)
Geranyl-PPMetabolite6699-20-3 (CAS)
FDFT1GeneProduct2222 (Entrez Gene)
(S)-2,3-EpoxysqualeneMetabolite9029-62-3 (CAS)
DHCR7GeneProduct1717 (Entrez Gene)
FDPSGeneProduct2224 (Entrez Gene)
SC5DLGeneProduct6309 (Entrez Gene)
LathosterolMetabolite80-99-9 (CAS)
LSSGeneProduct4047 (Entrez Gene)
HMG-CoAMetabolite (CAS)
SQLEGeneProduct6713 (Entrez Gene)
Mevalonic acid-5PMetabolite73566-35-5 (CAS)
PMVKGeneProduct10654 (Entrez Gene)
farnesyl pyrophosphateMetabolite13058-04-3 (CAS)
NSDHLGeneProduct50814 (Entrez Gene)
DimethylallylpyrophosphateMetabolite358-72-5 (CAS)
CYP51A1GeneProduct1595 (Entrez Gene)
LanosterinMetabolite79-63-0 (CAS)
SC4MOLGeneProduct6307 (Entrez Gene)
isopentenyl pyrophosphateMetabolite358-71-4 (CAS)
Acetyl-CoAMetabolite72-89-9 (CAS)
SREBF2GeneProductENSG00000198911 (Ensembl Human)
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