Phase 1 - Functionalization of compounds (Homo sapiens)

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Description

Phase 1 of metabolism is concerned with functionalization, that is the introduction or exposure of functional groups on the chemical structure of a compound. This provides a 'handle' for phase 2 conjugating species with which to react with. Many xenobiotics are lipophilic and almost chemically inert (e.g. PAHs) so would not necessarily undergo a phase 2 reaction. Making them more chemically reactive would facilitate their excretion but also increases their chance of reacting with cellular macromolecules (e.g. proteins, DNA). There is a fine balance between producing a more reactive metabolite and conjugation reactions.
There are two groups of enzymes in phase 1 - oxidoreductases and hydrolases. Oxidoreductases introduce an oxygen atom into or remove electrons from their substrates. The major oxidoreductase enzyme system is called the P450 monooxygenases. Other systems include flavin-containing monooxygenases (FMO), cyclooxygenases (COX) and monoamine oxidases (MAO). Hydrolases hydrolyse esters, amides, epoxides and glucuronides.Original Pathway at Reactome: http://www.reactome.org/PathwayBrowser/#DB=gk_current&FOCUS_SPECIES_ID=48887&FOCUS_PATHWAY_ID=211945

Ontology Tags

 

Bibliography

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  101. Nugteren DH, Hazelhof E.; ''Isolation and properties of intermediates in prostaglandin biosynthesis.''; PubMed
  102. Jin R, Koop DR, Raucy JL, Lasker JM.; ''Role of human CYP4F2 in hepatic catabolism of the proinflammatory agent leukotriene B4.''; PubMed
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  107. Kawamoto T, Mitsuuchi Y, Toda K, Yokoyama Y, Miyahara K, Miura S, Ohnishi T, Ichikawa Y, Nakao K, Imura H.; ''Role of steroid 11 beta-hydroxylase and steroid 18-hydroxylase in the biosynthesis of glucocorticoids and mineralocorticoids in humans.''; PubMed
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  111. He XY, Shen J, Hu WY, Ding X, Lu AY, Hong JY.; ''Identification of Val117 and Arg372 as critical amino acid residues for the activity difference between human CYP2A6 and CYP2A13 in coumarin 7-hydroxylation.''; PubMed
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History

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CompareRevisionActionTimeUserComment
76834view08:05, 17 July 2014ReactomeTeamFixed remaining interactions
76538view11:51, 16 July 2014ReactomeTeamFixed remaining interactions
75871view09:52, 11 June 2014ReactomeTeamRe-fixing comment source
75571view10:38, 10 June 2014ReactomeTeamReactome 48 Update
74926view13:45, 8 May 2014AnweshaFixing comment source for displaying WikiPathways description
74570view08:36, 30 April 2014ReactomeTeamReactome46
72910view15:13, 14 December 2013EgonwArgh...
72908view15:12, 14 December 2013EgonwFixed the Uniprot-TrEMBL data sources.
72906view15:09, 14 December 2013EgonwUpdated the UniProt data source with UniProt/TrEMBL.
42095view21:56, 4 March 2011MaintBotAutomatic update
39905view05:55, 21 January 2011MaintBotNew pathway

External references

View all...
NameTypeDatabase referenceComment
MTZ-SOXMetaboliteCHEBI:63828 (ChEBI)
19-OH PGH2MetaboliteCHEBI:63912 (ChEBI)
Cytochrome P450 (CYP2A3 based)ProteinREACT_165042 (Reactome) This CandidateSet contains sequences identified by William Pearson's analysis of Reactome catalyst entities. Catalyst entity sequences were used to identify analagous sequences that shared overall homology and active site homology. Sequences in this Candidate set were identified in an April 24, 2012 analysis.
TXA2MetaboliteCHEBI:15627 (ChEBI)
NAD+MetaboliteCHEBI:15846 (ChEBI)
PGH2MetaboliteCHEBI:15554 (ChEBI)
HatRAMetaboliteCHEBI:63795 (ChEBI)
e-MetaboliteCHEBI:10545 (ChEBI)
5HTMetaboliteCHEBI:28790 (ChEBI)
TBXAS1ProteinP24557 (Uniprot-TrEMBL)
DEXTMetaboliteCHEBI:29133 (ChEBI)
H2OMetaboliteCHEBI:15377 (ChEBI)
Cytochrome P450 (CYP8A1 based)ProteinREACT_165317 (Reactome) This CandidateSet contains sequences identified by William Pearson's analysis of Reactome catalyst entities. Catalyst entity sequences were used to identify analagous sequences that shared overall homology and active site homology. Sequences in this Candidate set were identified in an April 24, 2012 analysis.
PGI2MetaboliteCHEBI:15552 (ChEBI)
MTZMetaboliteCHEBI:50673 (ChEBI)
NADP+MetaboliteCHEBI:18009 (ChEBI)
MAOA [mitochondrial outer membrane]ProteinP21397 (Uniprot-TrEMBL)
H+MetaboliteCHEBI:15378 (ChEBI)
APrOHMetaboliteCHEBI:18090 (ChEBI)
NADPHMetaboliteCHEBI:16474 (ChEBI)
ACSS2ProteinQ9NR19 (Uniprot-TrEMBL)
E1MetaboliteCHEBI:17263 (ChEBI)
Cytochrome P450 (CYP2E1 based)ProteinREACT_161337 (Reactome) This CandidateSet contains sequences identified by William Pearson's analysis of Reactome catalyst entities. Catalyst entity sequences were used to identify analagous sequences that shared overall homology and active site homology. Sequences in this Candidate set were identified in an April 24, 2012 analysis.
DOCMetaboliteCHEBI:16973 (ChEBI)
Cytochrome P450 (CYP3A7 based)ProteinREACT_164659 (Reactome) This CandidateSet contains sequences identified by William Pearson's analysis of Reactome catalyst entities. Catalyst entity sequences were used to identify analagous sequences that shared overall homology and active site homology. Sequences in this Candidate set were identified in an April 24, 2012 analysis.
25-hydroxycholesterolMetaboliteCHEBI:42977 (ChEBI)
O2MetaboliteCHEBI:15379 (ChEBI)
CYP11A1ProteinP05108 (Uniprot-TrEMBL)
INDOLMetaboliteCHEBI:16881 (ChEBI)
Cholest-5-ene-3beta,7alpha,25-triolMetaboliteCHEBI:37623 (ChEBI)
TAMMetaboliteCHEBI:41774 (ChEBI)
LNSOLMetaboliteCHEBI:16521 (ChEBI)
FMO1 (FAD cofactor)ComplexREACT_14390 (Reactome)
CORSTMetaboliteCHEBI:16827 (ChEBI)
NH3MetaboliteCHEBI:16134 (ChEBI)
CYP17A1ProteinP05093 (Uniprot-TrEMBL)
NASPMMetaboliteCHEBI:17927 (ChEBI)
P4MetaboliteCHEBI:17026 (ChEBI)
FAD [peroxisomal matrix]MetaboliteCHEBI:16238 (ChEBI)
4,4-dimethylcholesta-8(9),14,24-trien-3beta-olMetaboliteCHEBI:17813 (ChEBI)
Ac-CoAMetaboliteCHEBI:15351 (ChEBI)
20alpha,22beta dihydroxycholesterolMetaboliteCHEBI:1294 (ChEBI)
PPiMetaboliteCHEBI:29888 (ChEBI)
CORTMetaboliteCHEBI:17650 (ChEBI)
PTGS1 dimerComplexREACT_19925 (Reactome)
PregnenoloneMetaboliteCHEBI:16581 (ChEBI)
SMOXProteinQ9NWM0 (Uniprot-TrEMBL)
24-hydroxycholesterolMetaboliteCHEBI:34310 (ChEBI)
Cytochrome P450 (CYP11B2 based)ProteinREACT_165394 (Reactome) This CandidateSet contains sequences identified by William Pearson's analysis of Reactome catalyst entities. Catalyst entity sequences were used to identify analagous sequences that shared overall homology and active site homology. Sequences in this Candidate set were identified in an April 24, 2012 analysis.
CholesterolMetaboliteCHEBI:16113 (ChEBI)
Cytochrome P450 (CYP2J2 based)ProteinREACT_165599 (Reactome) This CandidateSet contains sequences identified by William Pearson's analysis of Reactome catalyst entities. Catalyst entity sequences were used to identify analagous sequences that shared overall homology and active site homology. Sequences in this Candidate set were identified in an April 24, 2012 analysis.
CYP51A1ProteinQ16850 (Uniprot-TrEMBL)
Cytochrome P450 (CYP4F11 based)ProteinREACT_164168 (Reactome) This CandidateSet contains sequences identified by William Pearson's analysis of Reactome catalyst entities. Catalyst entity sequences were used to identify analagous sequences that shared overall homology and active site homology. Sequences in this Candidate set were identified in an April 24, 2012 analysis.
EST17bMetaboliteCHEBI:16469 (ChEBI)
HcRAMetaboliteCHEBI:63802 (ChEBI)
4-OH-EstradiolMetaboliteCHEBI:62845 (ChEBI)
CYP26A1ProteinO43174 (Uniprot-TrEMBL)
7 alpha-hydroxycholesterolMetaboliteCHEBI:17500 (ChEBI)
HPALMMetaboliteCHEBI:37248 (ChEBI)
Cholest-5-ene-3beta,7alpha,24(S)-triolMetaboliteCHEBI:37640 (ChEBI)
TAMOMetaboliteCHEBI:63825 (ChEBI)
17alpha-hydroxypregnenoloneMetaboliteCHEBI:28750 (ChEBI)
FMO3 [endoplasmic reticulum membrane]ProteinP31513 (Uniprot-TrEMBL)
HCOOHMetaboliteCHEBI:30751 (ChEBI)
FMO2(2-535)

[endoplasmic

reticulum membrane]
ProteinQ99518 (Uniprot-TrEMBL)
CYP1B1ProteinQ16678 (Uniprot-TrEMBL)
PGG2MetaboliteCHEBI:27647 (ChEBI)
PREGMetaboliteCHEBI:16581 (ChEBI)
MAOB-FAD complexComplexREACT_4664 (Reactome)
CYP27A1ProteinQ02318 (Uniprot-TrEMBL)
TYRMetaboliteCHEBI:15760 (ChEBI)
CYP19A1(2-503)ProteinP11511 (Uniprot-TrEMBL)
PEAMetaboliteCHEBI:18397 (ChEBI)
4-Androstene-3, 17-dioneMetaboliteCHEBI:16422 (ChEBI)
3-acetamidopropanalMetaboliteCHEBI:30322 (ChEBI)
CYP39A1ProteinQ9NYL5 (Uniprot-TrEMBL)
SPMMetaboliteCHEBI:16610 (ChEBI)
11-deoxycortisolMetaboliteCHEBI:28324 (ChEBI)
CH3CHOMetaboliteCHEBI:15343 (ChEBI)
CYP21A2ProteinP08686 (Uniprot-TrEMBL)
NADHMetaboliteCHEBI:16908 (ChEBI)
CYP46A1ProteinQ9Y6A2 (Uniprot-TrEMBL)
ALDH2 [mitochondrial matrix]ProteinP05091 (Uniprot-TrEMBL)
ISCALMetaboliteCHEBI:17998 (ChEBI)
ALDH1A1 [cytosol]ProteinP00352 (Uniprot-TrEMBL)
27-hydroxycholesterolMetaboliteCHEBI:17703 (ChEBI)
ACSS1ProteinQ9NUB1 (Uniprot-TrEMBL)
4-cholesten-7alpha, 12alpha-diol-3-oneMetaboliteCHEBI:28477 (ChEBI)
20oh-LTB4MetaboliteCHEBI:15646 (ChEBI)
4-cholesten-7alpha,12alpha,24(S)-triol-3-oneMetaboliteCHEBI:63839 (ChEBI)
heme b [endoplasmic reticulum membrane]MetaboliteCHEBI:26355 (ChEBI)
4-cholesten-7alpha-ol-3-oneMetaboliteCHEBI:17899 (ChEBI)
CYP2S1ProteinQ96SQ9 (Uniprot-TrEMBL)
4-cholesten-7alpha,24(S)-diol-3-oneMetaboliteCHEBI:63838 (ChEBI)
CYP2U1ProteinQ7Z449 (Uniprot-TrEMBL)
4-cholesten-7alpha,12alpha,27-triol-3-oneMetaboliteCHEBI:48333 (ChEBI)
Cytochrome P450 (CYP4B1 based)ProteinREACT_164913 (Reactome) This CandidateSet contains sequences identified by William Pearson's analysis of Reactome catalyst entities. Catalyst entity sequences were used to identify analagous sequences that shared overall homology and active site homology. Sequences in this Candidate set were identified in an April 24, 2012 analysis.
4-cholesten-7alpha,27-diol-3-oneMetaboliteCHEBI:48825 (ChEBI)
Cytochrome P450 (CYP3A5 based)ProteinREACT_165182 (Reactome) This CandidateSet contains sequences identified by William Pearson's analysis of Reactome catalyst entities. Catalyst entity sequences were used to identify analagous sequences that shared overall homology and active site homology. Sequences in this Candidate set were identified in an April 24, 2012 analysis.
Arachidonic acidMetaboliteCHEBI:15843 (ChEBI)
Cytochrome P450 (CYP2C18 based)ProteinREACT_165418 (Reactome) This CandidateSet contains sequences identified by William Pearson's analysis of Reactome catalyst entities. Catalyst entity sequences were used to identify analagous sequences that shared overall homology and active site homology. Sequences in this Candidate set were identified in an April 24, 2012 analysis.
cis-EETMetaboliteREACT_14302 (Reactome)
Cytochrome P450 (CYP4F8 based)ProteinREACT_165609 (Reactome) This CandidateSet contains sequences identified by William Pearson's analysis of Reactome catalyst entities. Catalyst entity sequences were used to identify analagous sequences that shared overall homology and active site homology. Sequences in this Candidate set were identified in an April 24, 2012 analysis.
DDCXMetaboliteCHEBI:30805 (ChEBI)
Cytochrome P450 (CYP26C1 based)ProteinREACT_165169 (Reactome) This CandidateSet contains sequences identified by William Pearson's analysis of Reactome catalyst entities. Catalyst entity sequences were used to identify analagous sequences that shared overall homology and active site homology. Sequences in this Candidate set were identified in an April 24, 2012 analysis.
omega-Hydroxydodecanoic acidMetaboliteCHEBI:39567 (ChEBI)
Cytochrome P450 (CYP8B1 based)ProteinREACT_164336 (Reactome) This CandidateSet contains sequences identified by William Pearson's analysis of Reactome catalyst entities. Catalyst entity sequences were used to identify analagous sequences that shared overall homology and active site homology. Sequences in this Candidate set were identified in an April 24, 2012 analysis.
12-hydroxy-5,8,10,14-eicosatetraenoic acidMetaboliteCHEBI:19138 (ChEBI)
9cisRAMetaboliteCHEBI:50648 (ChEBI)
18-hydroxyarachidonateMetaboliteCHEBI:63590 (ChEBI)
atRAMetaboliteCHEBI:15367 (ChEBI)
HTOLBMetaboliteCHEBI:63799 (ChEBI)
CYP26B1ProteinQ9NR63 (Uniprot-TrEMBL)
TESMetaboliteCHEBI:17347 (ChEBI)
19-hydroxyarachidonic acidMetaboliteCHEBI:63998 (ChEBI)
N-demethylated loperamideMetaboliteCHEBI:64043 (ChEBI)
OxindoleMetaboliteCHEBI:31697 (ChEBI)
6BHTMetaboliteCHEBI:34477 (ChEBI)
3,16-dihydroxypalmitateMetaboliteCHEBI:63904 (ChEBI)
HCPMMetaboliteCHEBI:1864 (ChEBI)
TMAOMetaboliteCHEBI:15724 (ChEBI)
CYP1A1ProteinP04798 (Uniprot-TrEMBL)
TMAMetaboliteCHEBI:18139 (ChEBI)
TBMMetaboliteCHEBI:27999 (ChEBI)
FMO3 (FAD cofactor)ComplexREACT_14498 (Reactome)
HDBQMetaboliteCHEBI:63800 (ChEBI)
FAD [endoplasmic reticulum membrane]MetaboliteCHEBI:16238 (ChEBI)
HPTXLMetaboliteCHEBI:63859 (ChEBI)
FMO2 (FAD, Mg2+ cofactors)ComplexREACT_14675 (Reactome)
CPMMetaboliteCHEBI:4026 (ChEBI)
Mg2+ [endoplasmic reticulum membrane]MetaboliteCHEBI:18420 (ChEBI)
DSQMetaboliteCHEBI:34665 (ChEBI)
FMO1 [endoplasmic reticulum lumen]ProteinQ01740 (Uniprot-TrEMBL)
C2H4MetaboliteCHEBI:18153 (ChEBI)
MAOA-FAD complexComplexREACT_5113 (Reactome)
COUMMetaboliteCHEBI:28794 (ChEBI)
FAD [mitochondrial outer membrane]MetaboliteCHEBI:16238 (ChEBI)
MINDMetaboliteCHEBI:9171 (ChEBI)
MAOB [mitochondrial outer membrane]ProteinP27338 (Uniprot-TrEMBL)
EtOMetaboliteCHEBI:27561 (ChEBI)
H2O2MetaboliteCHEBI:16240 (ChEBI)
LosecMetaboliteCHEBI:7772 (ChEBI)
HPHACMetaboliteCHEBI:15621 (ChEBI)
AFTB1MetaboliteCHEBI:2504 (ChEBI)
HIALDMetaboliteCHEBI:50157 (ChEBI)
PhenytoinMetaboliteCHEBI:8107 (ChEBI)
PhenylacetaldehydeMetaboliteCHEBI:16424 (ChEBI)
3MEINMetaboliteCHEBI:63905 (ChEBI)
NASPNMetaboliteCHEBI:17312 (ChEBI)
LPAMMetaboliteCHEBI:6532 (ChEBI)
SPNMetaboliteCHEBI:15746 (ChEBI)
HOMZMetaboliteCHEBI:63840 (ChEBI)
PutrescineMetaboliteCHEBI:17148 (ChEBI)
HCOUMetaboliteCHEBI:27510 (ChEBI)
PAO-FAD complexComplexREACT_3389 (Reactome)
PTXLMetaboliteCHEBI:45863 (ChEBI)
PAOX(2-649) [peroxisomal matrix]ProteinQ6QHF9 (Uniprot-TrEMBL)
HPHTMetaboliteCHEBI:63804 (ChEBI)
AMPMetaboliteCHEBI:16027 (ChEBI)
Aflatoxin exo-8,9-oxideMetaboliteCHEBI:2505 (ChEBI)
ATPMetaboliteCHEBI:15422 (ChEBI)
ParaxanthineMetaboliteCHEBI:25858 (ChEBI)
CoA-SHMetaboliteCHEBI:15346 (ChEBI)
CH2OMetaboliteCHEBI:16842 (ChEBI)
aldehyde

dehydrogenase, mitochondrial,

tetramer
ComplexREACT_2466 (Reactome)
NHABPMetaboliteCHEBI:16580 (ChEBI)
CH3COO-MetaboliteCHEBI:15366 (ChEBI)
CAFMetaboliteCHEBI:27732 (ChEBI)
aldehyde

dehydrogenase 1A1

tetramer
ComplexREACT_5868 (Reactome)
ABPHMetaboliteCHEBI:1784 (ChEBI)
EtOHMetaboliteCHEBI:16236 (ChEBI)
CYP1A2ProteinP05177 (Uniprot-TrEMBL)
alcohol

dehydrogenase

complex
REACT_21845 (Reactome)
HALOMetaboliteCHEBI:5615 (ChEBI)
DEXMMetaboliteCHEBI:4470 (ChEBI)
2CEOMetaboliteCHEBI:29129 (ChEBI)
LTB4MetaboliteCHEBI:15647 (ChEBI)
Acetaminophen (TN TYLENOL)MetaboliteCHEBI:46195 (ChEBI)
POMC(138-176)ProteinP01189 (Uniprot-TrEMBL)
TFACMetaboliteCHEBI:29138 (ChEBI)
PTGS1 [endoplasmic reticulum membrane]ProteinP23219 (Uniprot-TrEMBL)
CCl4MetaboliteCHEBI:27385 (ChEBI)
Cytochrome P450 (CYP7B1 based)ProteinREACT_160403 (Reactome) This CandidateSet contains sequences identified by William Pearson's analysis of Reactome catalyst entities. Catalyst entity sequences were used to identify analagous sequences that shared overall homology and active site homology. Sequences in this Candidate set were identified in an April 24, 2012 analysis.
Cl-MetaboliteCHEBI:17996 (ChEBI)
Cytochrome P450 (CYP26A1 based)ProteinREACT_160369 (Reactome) This CandidateSet contains sequences identified by William Pearson's analysis of Reactome catalyst entities. Catalyst entity sequences were used to identify analagous sequences that shared overall homology and active site homology. Sequences in this Candidate set were identified in an April 24, 2012 analysis.
Trichloromethyl radicalREACT_4348 (Reactome)
CYP3A43ProteinQ9HB55 (Uniprot-TrEMBL)
H2MetaboliteCHEBI:18276 (ChEBI)
Cytochrome P450 (CYP2C8 based)ProteinREACT_165596 (Reactome) This CandidateSet contains sequences identified by William Pearson's analysis of Reactome catalyst entities. Catalyst entity sequences were used to identify analagous sequences that shared overall homology and active site homology. Sequences in this Candidate set were identified in an April 24, 2012 analysis.
VCMetaboliteCHEBI:28509 (ChEBI)
Cytochrome P450 (CYP2D6 based)ProteinREACT_164947 (Reactome) This CandidateSet contains sequences identified by William Pearson's analysis of Reactome catalyst entities. Catalyst entity sequences were used to identify analagous sequences that shared overall homology and active site homology. Sequences in this Candidate set were identified in an April 24, 2012 analysis.
HBrMetaboliteCHEBI:47266 (ChEBI)
Cytochrome P450 (CYP2C9 based)ProteinREACT_164982 (Reactome) This CandidateSet contains sequences identified by William Pearson's analysis of Reactome catalyst entities. Catalyst entity sequences were used to identify analagous sequences that shared overall homology and active site homology. Sequences in this Candidate set were identified in an April 24, 2012 analysis.
C6H6MetaboliteCHEBI:16716 (ChEBI)
Cytochrome P450 (CYP11B1 based)ProteinREACT_165034 (Reactome) This CandidateSet contains sequences identified by William Pearson's analysis of Reactome catalyst entities. Catalyst entity sequences were used to identify analagous sequences that shared overall homology and active site homology. Sequences in this Candidate set were identified in an April 24, 2012 analysis.
PhOHMetaboliteCHEBI:15882 (ChEBI)
Cytochrome P450 (CYP2B6 based)ProteinREACT_165424 (Reactome) This CandidateSet contains sequences identified by William Pearson's analysis of Reactome catalyst entities. Catalyst entity sequences were used to identify analagous sequences that shared overall homology and active site homology. Sequences in this Candidate set were identified in an April 24, 2012 analysis.
NABQIMetaboliteCHEBI:29132 (ChEBI)
Cytochrome P450 (CYP7A1 based)ProteinREACT_165338 (Reactome) This CandidateSet contains sequences identified by William Pearson's analysis of Reactome catalyst entities. Catalyst entity sequences were used to identify analagous sequences that shared overall homology and active site homology. Sequences in this Candidate set were identified in an April 24, 2012 analysis.
VD3MetaboliteCHEBI:28940 (ChEBI)
Cytochrome P450 (CYP2F1 based)ProteinREACT_164521 (Reactome) This CandidateSet contains sequences identified by William Pearson's analysis of Reactome catalyst entities. Catalyst entity sequences were used to identify analagous sequences that shared overall homology and active site homology. Sequences in this Candidate set were identified in an April 24, 2012 analysis.
CDLMetaboliteCHEBI:17933 (ChEBI)
Cytochrome P450 (CYP2C19 based)ProteinREACT_164482 (Reactome) This CandidateSet contains sequences identified by William Pearson's analysis of Reactome catalyst entities. Catalyst entity sequences were used to identify analagous sequences that shared overall homology and active site homology. Sequences in this Candidate set were identified in an April 24, 2012 analysis.
CYP2R1ProteinQ6VVX0 (Uniprot-TrEMBL)
Cytochrome P450 (CYP4F2/4F3 based)ProteinREACT_125551 (Reactome) This CandidateSet contains sequences identified by William Pearson's analysis of Reactome catalyst entities. Catalyst entity sequences were used to identify analagous sequences that shared overall homology and active site homology. Sequences in this Candidate set were identified in an April 24, 2012 analysis.
1,25-dihydroxyvitamin D3MetaboliteCHEBI:17823 (ChEBI)
Cytochrome P450 (CYP4A11 based)ProteinREACT_165074 (Reactome) This CandidateSet contains sequences identified by William Pearson's analysis of Reactome catalyst entities. Catalyst entity sequences were used to identify analagous sequences that shared overall homology and active site homology. Sequences in this Candidate set were identified in an April 24, 2012 analysis.
1,24,25-trihydroxyvitamin D3MetaboliteCHEBI:63911 (ChEBI)
Cytochrome P450 (CYP2A13 based)ProteinREACT_164514 (Reactome) This CandidateSet contains sequences identified by William Pearson's analysis of Reactome catalyst entities. Catalyst entity sequences were used to identify analagous sequences that shared overall homology and active site homology. Sequences in this Candidate set were identified in an April 24, 2012 analysis.
CYP24A1ProteinQ07973 (Uniprot-TrEMBL)
Cytochrome P450 (CYP2W1 based)ProteinREACT_165430 (Reactome) This CandidateSet contains sequences identified by William Pearson's analysis of Reactome catalyst entities. Catalyst entity sequences were used to identify analagous sequences that shared overall homology and active site homology. Sequences in this Candidate set were identified in an April 24, 2012 analysis.
CTLMetaboliteCHEBI:17823 (ChEBI)
Cytochrome P450 (CYP4F12 based)ProteinREACT_164281 (Reactome) This CandidateSet contains sequences identified by William Pearson's analysis of Reactome catalyst entities. Catalyst entity sequences were used to identify analagous sequences that shared overall homology and active site homology. Sequences in this Candidate set were identified in an April 24, 2012 analysis.
CYP27B1(?-508)ProteinO15528 (Uniprot-TrEMBL) The start coordinate is not yet known
Cytochrome P450 (CYPIIIA4 based)ProteinREACT_165595 (Reactome) This CandidateSet contains sequences identified by William Pearson's analysis of Reactome catalyst entities. Catalyst entity sequences were used to identify analagous sequences that shared overall homology and active site homology. Sequences in this Candidate set were identified in an April 24, 2012 analysis.
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