Phase 1 - Functionalization of compounds (Homo sapiens)

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Description

Phase 1 of metabolism is concerned with functionalization, that is the introduction or exposure of functional groups on the chemical structure of a compound. This provides a 'handle' for phase 2 conjugating species with which to react with. Many xenobiotics are lipophilic and almost chemically inert (e.g. PAHs) so would not necessarily undergo a phase 2 reaction. Making them more chemically reactive would facilitate their excretion but also increases their chance of reacting with cellular macromolecules (e.g. proteins, DNA). There is a fine balance between producing a more reactive metabolite and conjugation reactions.
There are two groups of enzymes in phase 1 - oxidoreductases and hydrolases. Oxidoreductases introduce an oxygen atom into or remove electrons from their substrates. The major oxidoreductase enzyme system is called the P450 monooxygenases. Other systems include flavin-containing monooxygenases (FMO), cyclooxygenases (COX) and monoamine oxidases (MAO). Hydrolases hydrolyse esters, amides, epoxides and glucuronides. View original pathway at:Reactome.

Ontology Tags

 

Bibliography

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History

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CompareRevisionActionTimeUserComment
83057view09:47, 18 November 2015ReactomeTeamVersion54
76834view08:05, 17 July 2014ReactomeTeamFixed remaining interactions
76538view11:51, 16 July 2014ReactomeTeamFixed remaining interactions
75871view09:52, 11 June 2014ReactomeTeamRe-fixing comment source
75571view10:38, 10 June 2014ReactomeTeamReactome 48 Update
74926view13:45, 8 May 2014AnweshaFixing comment source for displaying WikiPathways description
74570view08:36, 30 April 2014ReactomeTeamReactome46
72910view15:13, 14 December 2013EgonwArgh...
72908view15:12, 14 December 2013EgonwFixed the Uniprot-TrEMBL data sources.
72906view15:09, 14 December 2013EgonwUpdated the UniProt data source with UniProt/TrEMBL.
42095view21:56, 4 March 2011MaintBotAutomatic update
39905view05:55, 21 January 2011MaintBotNew pathway

External references

View all...
NameTypeDatabase referenceComment
CYP26A1,B1,C1ComplexR-HSA-5362528 (Reactome)
CYP2C19 ProteinP33261 (Uniprot-TrEMBL)
19OH-PGH2MetaboliteCHEBI:63912 (ChEBI)
ALDH2 tetramerComplexR-HSA-71721 (Reactome)
TXA2MetaboliteCHEBI:15627 (ChEBI)
CYP3A5 ProteinP20815 (Uniprot-TrEMBL)
PGH2MetaboliteCHEBI:15554 (ChEBI)
MeOHMetaboliteCHEBI:17790 (ChEBI)
e-MetaboliteCHEBI:10545 (ChEBI)
ADH7 ProteinP40394 (Uniprot-TrEMBL)
TBXAS1ProteinP24557 (Uniprot-TrEMBL)
CYP2W1 ProteinQ8TAV3 (Uniprot-TrEMBL)
H2OMetaboliteCHEBI:15377 (ChEBI)
PTGIS ProteinQ16647 (Uniprot-TrEMBL)
PGI2MetaboliteCHEBI:15552 (ChEBI)
CYP11B2ProteinP19099 (Uniprot-TrEMBL)
NADP+MetaboliteCHEBI:18009 (ChEBI)
BZAMMetaboliteCHEBI:40538 (ChEBI)
H+MetaboliteCHEBI:15378 (ChEBI)
PPiMetaboliteCHEBI:29888 (ChEBI)
NADPHMetaboliteCHEBI:16474 (ChEBI)
PTGS1 ProteinP23219 (Uniprot-TrEMBL)
E1MetaboliteCHEBI:17263 (ChEBI)
CYP2A7 ProteinP20853 (Uniprot-TrEMBL)
11DCORSTMetaboliteCHEBI:16973 (ChEBI)
CYP4F22 ProteinQ6NT55 (Uniprot-TrEMBL)
25OH-CHOLMetaboliteCHEBI:42977 (ChEBI)
Cytochrome P450 (CYP2C19 based)ComplexR-HSA-3222363 (Reactome) This CandidateSet contains sequences identified by William Pearson's analysis of Reactome catalyst entities. Catalyst entity sequences were used to identify analagous sequences that shared overall homology and active site homology. Sequences in this Candidate set were identified in an April 24, 2012 analysis.
CHOL3b,7a,25TRIOLMetaboliteCHEBI:37623 (ChEBI)
NCOA1,2:RXRA:NR1H4:DCA,CDCA,LCHAComplexR-HSA-5340274 (Reactome)
LNSOLMetaboliteCHEBI:16521 (ChEBI)
CYP11A1 ProteinP05108 (Uniprot-TrEMBL)
CYP17A1ProteinP05093 (Uniprot-TrEMBL)
S-HMGSHMetaboliteCHEBI:48926 (ChEBI)
P4MetaboliteCHEBI:17026 (ChEBI)
HistMetaboliteCHEBI:18295 (ChEBI)
4,4DMCHOLtrienolMetaboliteCHEBI:17813 (ChEBI)
4-ethoxyanilineMetaboliteCHEBI:85505 (ChEBI)
20a,22b-DHCHOLMetaboliteCHEBI:1294 (ChEBI)
ALDH1A1 tetramerComplexR-HSA-71689 (Reactome)
CORTMetaboliteCHEBI:17650 (ChEBI)
ADH1B ProteinP00325 (Uniprot-TrEMBL)
PREGMetaboliteCHEBI:16581 (ChEBI)
LTB4MetaboliteCHEBI:15647 (ChEBI)
24OH-CHOLMetaboliteCHEBI:34310 (ChEBI)
CYP7A1 ProteinP22680 (Uniprot-TrEMBL)
CHOLMetaboliteCHEBI:16113 (ChEBI)
CYP2S1 ProteinQ96SQ9 (Uniprot-TrEMBL)
CYP51A1ProteinQ16850 (Uniprot-TrEMBL)
CYP2C18 ProteinP33260 (Uniprot-TrEMBL)
EST17bMetaboliteCHEBI:16469 (ChEBI)
CYP4B1 ProteinP13584 (Uniprot-TrEMBL)
4OH-EST17bMetaboliteCHEBI:62845 (ChEBI)
CYP11B1 ProteinP15538 (Uniprot-TrEMBL)
7 alpha-hydroxycholesterolMetaboliteCHEBI:17500 (ChEBI)
Cytochrome P450 (CYP7A1 based)ComplexR-HSA-3219435 (Reactome) This CandidateSet contains sequences identified by William Pearson's analysis of Reactome catalyst entities. Catalyst entity sequences were used to identify analagous sequences that shared overall homology and active site homology. Sequences in this Candidate set were identified in an April 24, 2012 analysis.
CHOL7a,24(S)DIOLMetaboliteCHEBI:37640 (ChEBI)
Cytochrome P450 (CYP4F8 based)ComplexR-HSA-3222393 (Reactome) This CandidateSet contains sequences identified by William Pearson's analysis of Reactome catalyst entities. Catalyst entity sequences were used to identify analagous sequences that shared overall homology and active site homology. Sequences in this Candidate set were identified in an April 24, 2012 analysis.
17aHPREGMetaboliteCHEBI:28750 (ChEBI)
Cytochrome P450 (CYP4F11 based)ComplexR-HSA-3229083 (Reactome) This CandidateSet contains sequences identified by William Pearson's analysis of Reactome catalyst entities. Catalyst entity sequences were used to identify analagous sequences that shared overall homology and active site homology. Sequences in this Candidate set were identified in an April 24, 2012 analysis.
HCOOHMetaboliteCHEBI:30751 (ChEBI)
NR1H4 ProteinQ96RI1 (Uniprot-TrEMBL)
CYP1B1ProteinQ16678 (Uniprot-TrEMBL)
9cRAMetaboliteCHEBI:50648 (ChEBI)
CYP27A1ProteinQ02318 (Uniprot-TrEMBL)
FDX1L ProteinQ6P4F2 (Uniprot-TrEMBL)
CYP19A1ProteinP11511 (Uniprot-TrEMBL)
Cytochrome P450 (CYP4F3 based)ComplexR-HSA-3222400 (Reactome) This CandidateSet contains sequences identified by William Pearson's analysis of Reactome catalyst entities. Catalyst entity sequences were used to identify analagous sequences that shared overall homology and active site homology. Sequences in this Candidate set were identified in an April 24, 2012 analysis.
ANDSTMetaboliteCHEBI:16422 (ChEBI)
4HPCPMetaboliteCHEBI:196991 (ChEBI)
CYP39A1ProteinQ9NYL5 (Uniprot-TrEMBL)
CES2 ProteinO00748 (Uniprot-TrEMBL)
11DCORTMetaboliteCHEBI:28324 (ChEBI)
Ca2+ MetaboliteCHEBI:29108 (ChEBI)
CYP21A2ProteinP08686 (Uniprot-TrEMBL)
ALDH1B1 tetramerComplexR-HSA-5696086 (Reactome)
CYP46A1ProteinQ9Y6A2 (Uniprot-TrEMBL)
CoA-SHMetaboliteCHEBI:15346 (ChEBI)
ISCALMetaboliteCHEBI:17998 (ChEBI)
CH3COOHMetaboliteCHEBI:15366 (ChEBI)
27OH-CHOLMetaboliteCHEBI:17703 (ChEBI)
CH3COO-MetaboliteCHEBI:15366 (ChEBI)
4CHOL7a,12aDONEMetaboliteCHEBI:28477 (ChEBI)
ADH1A ProteinP07327 (Uniprot-TrEMBL)
4CHOL7a,12a,24(S)TONEMetaboliteCHEBI:63839 (ChEBI)
ADH4 ProteinP08319 (Uniprot-TrEMBL)
4CHOL7aOLONEMetaboliteCHEBI:17899 (ChEBI)
DEXMMetaboliteCHEBI:4470 (ChEBI)
4CHOL7a,24(S)DONEMetaboliteCHEBI:63838 (ChEBI)
POMC(138-176)ProteinP01189 (Uniprot-TrEMBL)
4CHOL7a,12a,27TONEMetaboliteCHEBI:48333 (ChEBI)
Cytochrome P450 (CYP7B1 based)ComplexR-HSA-2975806 (Reactome) This CandidateSet contains sequences identified by William Pearson's analysis of Reactome catalyst entities. Catalyst entity sequences were used to identify analagous sequences that shared overall homology and active site homology. Sequences in this Candidate set were identified in an April 24, 2012 analysis.
4CHOL7a,27DONEMetaboliteCHEBI:48825 (ChEBI)
CYP2E1 ProteinP05181 (Uniprot-TrEMBL)
ARAMetaboliteCHEBI:15843 (ChEBI)
CYP2C9 ProteinP11712 (Uniprot-TrEMBL)
cis-EETComplexR-HSA-R-ALL-215062 (Reactome)
CYP2A6 ProteinP11509 (Uniprot-TrEMBL)
5,6-EET MetaboliteCHEBI:34450 (ChEBI)
CYP3A43ProteinQ9HB55 (Uniprot-TrEMBL)
8,9-EET MetaboliteCHEBI:34490 (ChEBI)
Cytochrome P450 (CYP2D6 based)ComplexR-HSA-3219409 (Reactome) This CandidateSet contains sequences identified by William Pearson's analysis of Reactome catalyst entities. Catalyst entity sequences were used to identify analagous sequences that shared overall homology and active site homology. Sequences in this Candidate set were identified in an April 24, 2012 analysis.
11,12-EET MetaboliteCHEBI:34130 (ChEBI)
Cytochrome P450 (CYP2C9 based)ComplexR-HSA-3219414 (Reactome) This CandidateSet contains sequences identified by William Pearson's analysis of Reactome catalyst entities. Catalyst entity sequences were used to identify analagous sequences that shared overall homology and active site homology. Sequences in this Candidate set were identified in an April 24, 2012 analysis.
14,15-EET MetaboliteCHEBI:34157 (ChEBI)
CYP4A22 ProteinQ5TCH4 (Uniprot-TrEMBL)
DDCXMetaboliteCHEBI:30805 (ChEBI)
CYP4F11 ProteinQ9HBI6 (Uniprot-TrEMBL)
12OH-DDCXMetaboliteCHEBI:39567 (ChEBI)
Cytochrome P450 (CYP2B6 based)ComplexR-HSA-3219427 (Reactome) This CandidateSet contains sequences identified by William Pearson's analysis of Reactome catalyst entities. Catalyst entity sequences were used to identify analagous sequences that shared overall homology and active site homology. Sequences in this Candidate set were identified in an April 24, 2012 analysis.
12-HETEMetaboliteCHEBI:19138 (ChEBI)
CYP3A7 ProteinP24462 (Uniprot-TrEMBL)
18OH-ARAMetaboliteCHEBI:63590 (ChEBI)
Cytochrome P450 (CYP2F1 based)ComplexR-HSA-3222321 (Reactome) This CandidateSet contains sequences identified by William Pearson's analysis of Reactome catalyst entities. Catalyst entity sequences were used to identify analagous sequences that shared overall homology and active site homology. Sequences in this Candidate set were identified in an April 24, 2012 analysis.
HTOLBMetaboliteCHEBI:63799 (ChEBI)
Cytochrome P450 (CYP4F2/4F3 based)ComplexR-HSA-2161611 (Reactome) This CandidateSet contains sequences identified by William Pearson's analysis of Reactome catalyst entities. Catalyst entity sequences were used to identify analagous sequences that shared overall homology and active site homology. Sequences in this Candidate set were identified in an April 24, 2012 analysis.
TESMetaboliteCHEBI:17347 (ChEBI)
Cytochrome P450 (CYP4A11 based)ComplexR-HSA-3222396 (Reactome) This CandidateSet contains sequences identified by William Pearson's analysis of Reactome catalyst entities. Catalyst entity sequences were used to identify analagous sequences that shared overall homology and active site homology. Sequences in this Candidate set were identified in an April 24, 2012 analysis.
N-demethylated loperamideMetaboliteCHEBI:64043 (ChEBI)
Cytochrome P450 (CYP2A13 based)ComplexR-HSA-3222449 (Reactome) This CandidateSet contains sequences identified by William Pearson's analysis of Reactome catalyst entities. Catalyst entity sequences were used to identify analagous sequences that shared overall homology and active site homology. Sequences in this Candidate set were identified in an April 24, 2012 analysis.
6BHTMetaboliteCHEBI:34477 (ChEBI)
Cytochrome P450 (CYP8B1 based)ComplexR-HSA-3229177 (Reactome) This CandidateSet contains sequences identified by William Pearson's analysis of Reactome catalyst entities. Catalyst entity sequences were used to identify analagous sequences that shared overall homology and active site homology. Sequences in this Candidate set were identified in an April 24, 2012 analysis.
HCPMMetaboliteCHEBI:1864 (ChEBI)
CDCA MetaboliteCHEBI:16755 (ChEBI)
CYP1A1ProteinP04798 (Uniprot-TrEMBL)
NCOA1 ProteinQ15788 (Uniprot-TrEMBL)
TBMMetaboliteCHEBI:27999 (ChEBI)
CYP26B1 ProteinQ9NR63 (Uniprot-TrEMBL)
HDBQMetaboliteCHEBI:63800 (ChEBI)
CYP26C1ProteinQ6V0L0 (Uniprot-TrEMBL)
HPTXLMetaboliteCHEBI:63859 (ChEBI)
FDX1 ProteinP10109 (Uniprot-TrEMBL)
CPMMetaboliteCHEBI:4026 (ChEBI)
(2Fe-2S)2+ MetaboliteCHEBI:33737 (ChEBI)
DSQMetaboliteCHEBI:34665 (ChEBI)
ALDOMetaboliteCHEBI:27584 (ChEBI)
C2H4MetaboliteCHEBI:18153 (ChEBI)
20OH-TrXA3MetaboliteCHEBI:83782 (ChEBI)
COUMMetaboliteCHEBI:28794 (ChEBI)
ADH5:2xZn2+ dimerComplexR-HSA-5692229 (Reactome)
MINDMetaboliteCHEBI:9171 (ChEBI)
ALDH3A1ProteinP30838 (Uniprot-TrEMBL)
EtOMetaboliteCHEBI:27561 (ChEBI)
CES1 trimer, CES2ComplexR-HSA-5693688 (Reactome)
LosecMetaboliteCHEBI:7772 (ChEBI)
BaP4,5-DHDMetaboliteCHEBI:81621 (ChEBI)
AFB1MetaboliteCHEBI:2504 (ChEBI)
AOC1 dimer:2xCu2+:4xCa2+ComplexR-HSA-5696130 (Reactome)
PhenytoinMetaboliteCHEBI:8107 (ChEBI)
4HPAAMetaboliteCHEBI:15621 (ChEBI)
3MEINMetaboliteCHEBI:63905 (ChEBI)
AOC3 dimer:2xCu2+:4xCa2+ComplexR-HSA-5696173 (Reactome)
LPAMMetaboliteCHEBI:6532 (ChEBI)
PHENMetaboliteCHEBI:8050 (ChEBI)
HOMZMetaboliteCHEBI:63840 (ChEBI)
O2MetaboliteCHEBI:15379 (ChEBI)
HCOUMetaboliteCHEBI:27510 (ChEBI)
Ac-CoAMetaboliteCHEBI:15351 (ChEBI)
PTXLMetaboliteCHEBI:45863 (ChEBI)
ALDH2 ProteinP05091 (Uniprot-TrEMBL)
HPHTMetaboliteCHEBI:63804 (ChEBI)
ACSS2ProteinQ9NR19 (Uniprot-TrEMBL)
AFXBOMetaboliteCHEBI:30725 (ChEBI)
ALDH1A1 ProteinP00352 (Uniprot-TrEMBL)
ParaxanthineMetaboliteCHEBI:25858 (ChEBI)
EtOHMetaboliteCHEBI:16236 (ChEBI)
CH2OMetaboliteCHEBI:16842 (ChEBI)
alcohol

dehydrogenase

complex
ComplexR-HSA-449883 (Reactome)
NHABPMetaboliteCHEBI:16580 (ChEBI)
Zn2+ MetaboliteCHEBI:29105 (ChEBI)
CAFMetaboliteCHEBI:27732 (ChEBI)
ADH1C ProteinP00326 (Uniprot-TrEMBL)
ABPHMetaboliteCHEBI:1784 (ChEBI)
ADH6 ProteinP28332 (Uniprot-TrEMBL)
CYP1A2ProteinP05177 (Uniprot-TrEMBL)
ACSS1ProteinQ9NUB1 (Uniprot-TrEMBL)
HALOMetaboliteCHEBI:5615 (ChEBI)
DEXTMetaboliteCHEBI:29133 (ChEBI)
2CEOMetaboliteCHEBI:29129 (ChEBI)
20OH-LTB4MetaboliteCHEBI:15646 (ChEBI)
Acetaminophen (TN TYLENOL)MetaboliteCHEBI:46195 (ChEBI)
PTGS1 dimerComplexR-HSA-428986 (Reactome)
TFACMetaboliteCHEBI:29138 (ChEBI)
heme b MetaboliteCHEBI:26355 (ChEBI)
CCl4MetaboliteCHEBI:27385 (ChEBI)
CYP7B1 ProteinO75881 (Uniprot-TrEMBL)
Cl-MetaboliteCHEBI:17996 (ChEBI)
Cytochrome P450 (CYP2E1 based)ComplexR-HSA-2990860 (Reactome) This CandidateSet contains sequences identified by William Pearson's analysis of Reactome catalyst entities. Catalyst entity sequences were used to identify analagous sequences that shared overall homology and active site homology. Sequences in this Candidate set were identified in an April 24, 2012 analysis.
Trichloromethyl radicalR-NUL-76433 (Reactome)
CYP2B6 ProteinP20813 (Uniprot-TrEMBL)
H2MetaboliteCHEBI:18276 (ChEBI)
CYP2C8 ProteinP10632 (Uniprot-TrEMBL)
VCMetaboliteCHEBI:28509 (ChEBI)
CYP2D6 ProteinP10635 (Uniprot-TrEMBL)
HBrMetaboliteCHEBI:47266 (ChEBI)
CYP2F1 ProteinP24903 (Uniprot-TrEMBL)
C6H6MetaboliteCHEBI:16716 (ChEBI)
CYP2A13 ProteinQ16696 (Uniprot-TrEMBL)
PhOHMetaboliteCHEBI:15882 (ChEBI)
CYP2S1ProteinQ96SQ9 (Uniprot-TrEMBL)
NABQIMetaboliteCHEBI:29132 (ChEBI)
Cytochrome P450 (CYP2C8 based)ComplexR-HSA-3215460 (Reactome) This CandidateSet contains sequences identified by William Pearson's analysis of Reactome catalyst entities. Catalyst entity sequences were used to identify analagous sequences that shared overall homology and active site homology. Sequences in this Candidate set were identified in an April 24, 2012 analysis.
VD3MetaboliteCHEBI:28940 (ChEBI)
CYP2U1ProteinQ7Z449 (Uniprot-TrEMBL)
CDLMetaboliteCHEBI:17933 (ChEBI)
CYP2J2 ProteinP51589 (Uniprot-TrEMBL)
CYP2R1ProteinQ6VVX0 (Uniprot-TrEMBL)
Cytochrome P450 (CYP2A3 based)ComplexR-HSA-3219412 (Reactome) This CandidateSet contains sequences identified by William Pearson's analysis of Reactome catalyst entities. Catalyst entity sequences were used to identify analagous sequences that shared overall homology and active site homology. Sequences in this Candidate set were identified in an April 24, 2012 analysis.
CTLMetaboliteCHEBI:17823 (ChEBI)
Cytochrome P450 (CYP4B1 based)ComplexR-HSA-3219417 (Reactome) This CandidateSet contains sequences identified by William Pearson's analysis of Reactome catalyst entities. Catalyst entity sequences were used to identify analagous sequences that shared overall homology and active site homology. Sequences in this Candidate set were identified in an April 24, 2012 analysis.
CTLAMetaboliteCHEBI:63911 (ChEBI)
CYP4A11 ProteinQ02928 (Uniprot-TrEMBL)
CYP24A1ProteinQ07973 (Uniprot-TrEMBL)
CYP4F2 ProteinP78329 (Uniprot-TrEMBL)
CYP27B1(?-508)ProteinO15528 (Uniprot-TrEMBL) The start coordinate is not yet known
CYP4F3 ProteinQ08477 (Uniprot-TrEMBL)
atRAMetaboliteCHEBI:15367 (ChEBI)
Cytochrome P450 (CYP11B1 based)ComplexR-HSA-3219421 (Reactome) This CandidateSet contains sequences identified by William Pearson's analysis of Reactome catalyst entities. Catalyst entity sequences were used to identify analagous sequences that shared overall homology and active site homology. Sequences in this Candidate set were identified in an April 24, 2012 analysis.
4OH-atRAMetaboliteCHEBI:63795 (ChEBI)
CYP11B2 ProteinP19099 (Uniprot-TrEMBL)
19HETEMetaboliteCHEBI:63998 (ChEBI)
Cytochrome P450 (CYP3A5 based)ComplexR-HSA-3219430 (Reactome) This CandidateSet contains sequences identified by William Pearson's analysis of Reactome catalyst entities. Catalyst entity sequences were used to identify analagous sequences that shared overall homology and active site homology. Sequences in this Candidate set were identified in an April 24, 2012 analysis.
INDOLMetaboliteCHEBI:16881 (ChEBI)
CYP3A4 ProteinP08684 (Uniprot-TrEMBL)
OxindoleMetaboliteCHEBI:31697 (ChEBI)
CYP3A43 ProteinQ9HB55 (Uniprot-TrEMBL)
3OH-PALMMetaboliteCHEBI:37248 (ChEBI)
Cytochrome P450 (CYP3A7 based)ComplexR-HSA-3219438 (Reactome) This CandidateSet contains sequences identified by William Pearson's analysis of Reactome catalyst entities. Catalyst entity sequences were used to identify analagous sequences that shared overall homology and active site homology. Sequences in this Candidate set were identified in an April 24, 2012 analysis.
3,16DOH-PALMMetaboliteCHEBI:63904 (ChEBI)
Cytochrome P450 (CYP2C18 based)ComplexR-HSA-3222327 (Reactome) This CandidateSet contains sequences identified by William Pearson's analysis of Reactome catalyst entities. Catalyst entity sequences were used to identify analagous sequences that shared overall homology and active site homology. Sequences in this Candidate set were identified in an April 24, 2012 analysis.
MTZMetaboliteCHEBI:50673 (ChEBI)
Cytochrome P450 (CYP2J2 based)ComplexR-HSA-3222379 (Reactome) This CandidateSet contains sequences identified by William Pearson's analysis of Reactome catalyst entities. Catalyst entity sequences were used to identify analagous sequences that shared overall homology and active site homology. Sequences in this Candidate set were identified in an April 24, 2012 analysis.
TMAOMetaboliteCHEBI:15724 (ChEBI)
CYP4F8 ProteinP98187 (Uniprot-TrEMBL)
TAMOMetaboliteCHEBI:63825 (ChEBI)
CYP4F12 ProteinQ9HCS2 (Uniprot-TrEMBL)
TMAMetaboliteCHEBI:18139 (ChEBI)
PTGIS,CYP8B1ComplexR-HSA-3222410 (Reactome) This CandidateSet contains sequences identified by William Pearson's analysis of Reactome catalyst entities. Catalyst entity sequences were used to identify analagous sequences that shared overall homology and active site homology. Sequences in this Candidate set were identified in an April 24, 2012 analysis.
TAMMetaboliteCHEBI:41774 (ChEBI)
CYP8B1 ProteinQ9UNU6 (Uniprot-TrEMBL)
FMO3:FADComplexR-HSA-217276 (Reactome)
Cytochrome P450 (CYP2W1 based)ComplexR-HSA-3229080 (Reactome) This CandidateSet contains sequences identified by William Pearson's analysis of Reactome catalyst entities. Catalyst entity sequences were used to identify analagous sequences that shared overall homology and active site homology. Sequences in this Candidate set were identified in an April 24, 2012 analysis.
FMO3 ProteinP31513 (Uniprot-TrEMBL)
Cytochrome P450 (CYP4F12 based)ComplexR-HSA-3229155 (Reactome) This CandidateSet contains sequences identified by William Pearson's analysis of Reactome catalyst entities. Catalyst entity sequences were used to identify analagous sequences that shared overall homology and active site homology. Sequences in this Candidate set were identified in an April 24, 2012 analysis.
FAD MetaboliteCHEBI:16238 (ChEBI)
Cytochrome P450 (CYPIIIA4 based)ComplexR-HSA-3229233 (Reactome) This CandidateSet contains sequences identified by William Pearson's analysis of Reactome catalyst entities. Catalyst entity sequences were used to identify analagous sequences that shared overall homology and active site homology. Sequences in this Candidate set were identified in an April 24, 2012 analysis.
MTZ-SOXMetaboliteCHEBI:63828 (ChEBI)
DCA MetaboliteCHEBI:28834 (ChEBI)
FMO2:FAD:Mg2+ComplexR-HSA-217317 (Reactome)
LCHA MetaboliteCHEBI:16325 (ChEBI)
FMO2 ProteinQ99518 (Uniprot-TrEMBL)
RXRA ProteinP19793 (Uniprot-TrEMBL)
Mg2+ MetaboliteCHEBI:18420 (ChEBI)
NCOA2 ProteinQ15596 (Uniprot-TrEMBL)
FMO1:FADComplexR-HSA-217261 (Reactome)
CYP26A1 ProteinO43174 (Uniprot-TrEMBL)
FMO1 ProteinQ01740 (Uniprot-TrEMBL)
CYP26C1 ProteinQ6V0L0 (Uniprot-TrEMBL)
PGG2MetaboliteCHEBI:27647 (ChEBI)
4OH-9cRAMetaboliteCHEBI:63802 (ChEBI)
MAOA:FADComplexR-HSA-141332 (Reactome)
CYP11A1:FDXR:FDX1,FDX1L (red.)ComplexR-HSA-5580249 (Reactome)
MAOA ProteinP21397 (Uniprot-TrEMBL)
FDXR ProteinP22570 (Uniprot-TrEMBL)
MAOB:FADComplexR-HSA-141326 (Reactome)
(2Fe-2S)(1+) MetaboliteCHEBI:33738 (ChEBI)
MAOB ProteinP27338 (Uniprot-TrEMBL)
CYP11A1:FDXR:FDX1,FDX1L (ox.)ComplexR-HSA-5580259 (Reactome)
NH3MetaboliteCHEBI:16134 (ChEBI)
CORSTMetaboliteCHEBI:16827 (ChEBI)
H2O2MetaboliteCHEBI:16240 (ChEBI)
18HCORSTMetaboliteCHEBI:16485 (ChEBI)
TYRMetaboliteCHEBI:15760 (ChEBI)
SMOX-3ProteinQ9NWM0-3 (Uniprot-TrEMBL)
HPHACMetaboliteCHEBI:15621 (ChEBI)
TrXA3MetaboliteCHEBI:15630 (ChEBI)
5HTMetaboliteCHEBI:28790 (ChEBI)
CYP4F22ProteinQ6NT55 (Uniprot-TrEMBL)
5HIALDMetaboliteCHEBI:50157 (ChEBI)
S-FGSHMetaboliteCHEBI:16225 (ChEBI)
PEAMetaboliteCHEBI:18397 (ChEBI)
ADH5 ProteinP11766 (Uniprot-TrEMBL)
PhenylacetaldehydeMetaboliteCHEBI:16424 (ChEBI)
CXPAMetaboliteCHEBI:3410 (ChEBI)
NASPMMetaboliteCHEBI:17927 (ChEBI)
COCNMetaboliteCHEBI:27958 (ChEBI)
NASPNMetaboliteCHEBI:17312 (ChEBI)
BEGMetaboliteCHEBI:41001 (ChEBI)
3AAPNALMetaboliteCHEBI:30322 (ChEBI)
CES1 ProteinP23141 (Uniprot-TrEMBL)
SPNMetaboliteCHEBI:15746 (ChEBI)
BaP4,5OMetaboliteCHEBI:34560 (ChEBI)
3APALMetaboliteCHEBI:18090 (ChEBI)
EPHX1ProteinP07099 (Uniprot-TrEMBL)
PTCNMetaboliteCHEBI:17148 (ChEBI)
I4AHMetaboliteCHEBI:27398 (ChEBI)
SPMMetaboliteCHEBI:16610 (ChEBI)
AOC1 ProteinP19801 (Uniprot-TrEMBL)
PAOX:FADComplexR-HSA-141346 (Reactome)
Cu2+ MetaboliteCHEBI:28694 (ChEBI)
PAOX ProteinQ6QHF9 (Uniprot-TrEMBL)
AOC2ProteinO75106 (Uniprot-TrEMBL)
CH3CHOMetaboliteCHEBI:15343 (ChEBI)
BZALMetaboliteCHEBI:17169 (ChEBI)
AMPMetaboliteCHEBI:16027 (ChEBI)
AOC3 ProteinQ16853 (Uniprot-TrEMBL)
NAD+MetaboliteCHEBI:15846 (ChEBI)
ALDH1B1 ProteinP30837 (Uniprot-TrEMBL)
ATPMetaboliteCHEBI:15422 (ChEBI)
acetyl groupMetaboliteCHEBI:40574 (ChEBI)
NADHMetaboliteCHEBI:16908 (ChEBI)
AADACProteinP22760 (Uniprot-TrEMBL)
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