Integrin-mediated Cell Adhesion (Homo sapiens)

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Curation Tags


Integrins are receptors that mediate attachment between a cell and the tissues surrounding it, which may be other cells or the extracellular matrix (ECM). They also play a role in cell signaling and thereby define cellular shape, mobility, and regulate the cell cycle. Source: Wikipedia

Ontology Tags



  1. Sepulveda JL, Gkretsi V, Wu C; ''Assembly and signaling of adhesion complexes.''; Curr Top Dev Biol, 2005 PubMed
  2. Hermeking H; ''The miR-34 family in cancer and apoptosis.''; Cell Death Differ, 2010 PubMed


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80036view00:19, 2 May 2015KhanspersAdded MIR34C
79982view15:27, 29 April 2015Zarianotated MYO-P gene
71391view18:42, 17 October 2013MaintBotAutomated update of data sources
71275view22:33, 16 October 2013MaintBotAutomated update of data sources
70020view01:51, 12 July 2013AlexanderPicoModified title
63223view21:02, 8 May 2013MaintBotUpdating gpml version
62693view21:36, 1 May 2013MaintBotupdated uniprot data source
44862view09:56, 6 October 2011MartijnVanIerselOntology Term : 'integrin mediated signaling pathway' added !
41226view23:45, 1 March 2011MaintBotRemoved redundant pathway information and comments
38886view19:04, 24 September 2010KhanspersAdded pathway link
38885view18:59, 24 September 2010Khanspers
35591view15:40, 12 February 2010Thomasadded literature
35590view15:38, 12 February 2010ThomasModified description
31991view13:14, 14 August 2009MaintBotFixed group labels
21067view11:30, 14 November 2008MaintBot[[Pathway:Homo sapiens:Integrin-mediated cell adhesion KEGG]] moved to [[Pathway:WP185]]: Moved to stable identifier
14947view16:14, 24 May 2008MartijnVanIersellinked up
13024view11:07, 17 May 2008MaintBotSticky edges patch by Sjoerd
8218view13:46, 7 January 2008MaintBot[[Pathway:Human:Integrin-mediated cell adhesion KEGG]] moved to [[Pathway:Homo sapiens:Integrin-mediated cell adhesion KEGG]]: Renaming species
7729view16:13, 18 December 2007MaintBotfixed category names
7268view12:41, 4 November 2007MaintBotAdded categories to GPML
6345view22:18, 22 May 2007169.230.77.174gpml file for [[Human:Integrin-mediated_cell_adhesion_KEGG]]

External references

View all...
NameTypeDatabase referenceComment
CRKGeneProduct1398 (Entrez Gene) CRK; v-crk sarcoma virus CT10 oncogene homolog (avian
ITGB8GeneProduct3696 (Entrez Gene)
SHC1GeneProduct6464 (Entrez Gene) SHC1; SHC (Src homology 2 domain containing) transforming protein 1
ITGA10GeneProduct8515 (Entrez Gene)
SHC3GeneProduct53358 (Entrez Gene) SHC3; neuronal Sh
ARAFGeneProduct369 (Entrez Gene) ARAF1; v-raf murine sarcoma 3611 viral oncogene homolog 1 [EC:2.7.1.-]
CAPN1GeneProduct823 (Entrez Gene) CAPN1; calpain 1 (mu/I) large subunit [EC:]
BRAFGeneProduct673 (Entrez Gene) BRAF; v-raf murine sarcoma viral oncogene homolog B1 [EC:2.7.1.-]
ITGAXGeneProduct3687 (Entrez Gene)
RAF1GeneProduct5894 (Entrez Gene) RAF1; v-raf-1 murine leukemia viral oncogene homolog 1 [EC:2.7.1.-]
ITGA7GeneProduct3679 (Entrez Gene)
MAPK4GeneProduct5596 (Entrez Gene) MAPK4; mitogen-activated protein kinase 4 [EC:2.7.1.-]
MAP2K6GeneProduct5608 (Entrez Gene) MAP2K6; mitogen-activated protein kinase kinase 6 [EC:2.7.1.-
MAPK7GeneProduct5598 (Entrez Gene) MAPK7; mitogen-activated protein kinase 7 [EC:2.7.1.-
MAPK1GeneProduct5594 (Entrez Gene) MAPK1; mitogen-activated protein kinase 1 [EC:2.7.1.-]
CAPNS1GeneProduct826 (Entrez Gene) CAPNS1; calpain small subunit 1 [EC:]
ITGA5GeneProduct3678 (Entrez Gene)
MYLK2GeneProduct85366 (Entrez Gene) MYLK2; myosin light chain kinase 2 skeletal muscle [EC:
ITGADGeneProduct3681 (Entrez Gene)
ARHGEF7GeneProduct8874 (Entrez Gene) ARHGEF7; Rho guanine nucleotide exchange factor (GEF) 7
ITGB4GeneProduct3691 (Entrez Gene)
RAC1GeneProduct5879 (Entrez Gene) RAC1; ras-related C3 botulinum toxin substrate 1 (rho family small GTP binding protein Rac1)
PXNGeneProduct5829 (Entrez Gene) PXN; paxillin
RAC2GeneProduct5880 (Entrez Gene) RAC2; ras-related C3 botulinum toxin substrate 2 (rho family small GTP binding protein Rac2)
CDC42GeneProduct998 (Entrez Gene) CDC42; cell division cycle 42 (GTP binding protein 25kD)
RAC3GeneProduct5881 (Entrez Gene) RAC3; ras-related C3 botulinum toxin substrate 3 (rho family small GTP binding protein Rac3)
MAP2K3GeneProduct5606 (Entrez Gene) MAP2K3; mitogen-activated protein kinase kinase 3 [EC:2.7.1.-]
PDPK1GeneProduct5170 (Entrez Gene) PDPK1; 3-phosphoinositide dependent protein kinase-1 [EC:]
AKT3GeneProduct10000 (Entrez Gene) AKT3; v-akt murine thymoma viral oncogene homolog 3 (protein kinase B gamma) [EC:2.7.1.-]
VAV2GeneProduct7410 (Entrez Gene) VAV2; vav 2 oncogene
RAP1AGeneProduct5906 (Entrez Gene) RAP1A; RAP1A member of RAS oncogene family
VAV3GeneProduct10451 (Entrez Gene) VAV3; vav 3 oncogene
MAP2K1GeneProduct5604 (Entrez Gene) MAP2K1; mitogen-activated protein kinase kinase 1 [EC:2.7.1.-]
ROCK2GeneProduct9475 (Entrez Gene) ROCK2; Rho-associated coiled-coil containing protein kinase
ITGA3GeneProduct3675 (Entrez Gene)
ROCK1GeneProduct6093 (Entrez Gene) ROCK1; Rho-associated coiled-coil containing protein kinase
ITGA8GeneProduct8516 (Entrez Gene)
SORBS1GeneProduct10580 (Entrez Gene) SH3D5; SH3-domain protein 5 (ponsin
ITGA2BGeneProduct3674 (Entrez Gene)
SOS1GeneProduct6654 (Entrez Gene) SOS1; son of sevenless homolog 1 (Drosophila)
ITGAMGeneProduct3684 (Entrez Gene)
GIT2GeneProduct9815 (Entrez Gene) GIT2; G protein-coupled receptor kinase-interactor 2
ITGB2GeneProduct3689 (Entrez Gene)
PIK3R2GeneProduct5296 (Entrez Gene) PIK3R2; phosphoinositide-3-kinase regulatory subunit polypeptide 2 (p85 beta)
ITGB6GeneProduct3694 (Entrez Gene)
ZYXGeneProduct7791 (Entrez Gene) ZYX; zyxin
TNS1GeneProduct7145 (Entrez Gene) TNS; tensi
CAV1GeneProduct857 (Entrez Gene) CAV1; caveolin 1 caveolae protein 22kD
PAK1GeneProduct5058 (Entrez Gene) PAK1; p21/Cdc42/Rac1-activated kinase 1 (STE20 homolog yeast) [EC:2.7.1.-]
CAV2GeneProduct858 (Entrez Gene) CAV2; caveolin 2
Phosphatidylinositol signaling systemPathway
CAV3GeneProduct859 (Entrez Gene) CAV3; caveolin 3
PAK6GeneProduct56924 (Entrez Gene) PAK6; p21(CDKN1A)-activated kinase
FYNGeneProduct2534 (Entrez Gene) FYN; FYN oncogene related to SRC FGR YES [EC:]
TLN1GeneProduct7094 (Entrez Gene) TLN1; talin 1
GRB2GeneProduct2885 (Entrez Gene) GRB2; growth factor receptor-bound protein 2
MAP2K5GeneProduct5607 (Entrez Gene) MAP2K5; mitogen-activated protein kinase kinase 5 [EC:2.7.1.-]
SEPP1GeneProduct6414 (Entrez Gene) SEPP1; selenoprotein P plasma
MAPK12GeneProduct6300 (Entrez Gene) MAPK12; mitogen-activated protein kinase 12 [EC:2.7.1.-]
HRASGeneProduct3265 (Entrez Gene)
DOCK1GeneProduct1793 (Entrez Gene) DOCK1; dedicator of cyto-kinesis
PTK2GeneProduct5747 (Entrez Gene) PTK2; PTK2 protein tyrosine kinase 2 [EC:
RAPGEF1GeneProduct2889 (Entrez Gene) GRF2; guanine nucleotide-releasing factor 2 (specific for crk proto-oncogene
RAP1BGeneProduct5908 (Entrez Gene) RAP1B; RAP1B member of RAS oncogene family
RHOGeneProduct6010 (Entrez Gene) RHO; rhodopsin (opsin 2 rod pigment) (retinitis pigmentosa 4 autosomal dominant)
MAPK6GeneProduct5597 (Entrez Gene) MAPK6; mitogen-activated protein kinase 6 [EC:2.7.1.-]
MAP2K2GeneProduct5605 (Entrez Gene) MAP2K2; mitogen-activated protein kinase kinase 2 [EC:2.7.1.-]
CSKGeneProduct1445 (Entrez Gene) CSK; c-src tyrosine kinase [EC:]
ITGA2GeneProduct3673 (Entrez Gene)
BCAR1GeneProduct9564 (Entrez Gene) BCAR1; breast cancer anti-estrogen resistance 1
ITGA4GeneProduct3676 (Entrez Gene)
SRCGeneProduct6714 (Entrez Gene) SRC; v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian) [EC:]
ITGA6GeneProduct3655 (Entrez Gene)
AKT1GeneProduct207 (Entrez Gene) AKT1; v-akt murine thymoma viral oncogene homolog 1 [EC:2.7.1.-]
ITGA9GeneProduct3680 (Entrez Gene)
AKT2GeneProduct208 (Entrez Gene) AKT2; v-akt murine thymoma viral oncogene homolog 2 [EC:2.7.1.-]
ITGA11GeneProduct22801 (Entrez Gene)
MYO-PGeneProductENSG00000138347 (Ensembl)
ITGAEGeneProduct3682 (Entrez Gene)
ITGALGeneProduct3683 (Entrez Gene)
CAPN2GeneProduct824 (Entrez Gene) CAPN2; calpain 2 (m/II) large subunit [EC:]
ITGAVGeneProduct3685 (Entrez Gene)
CAPN3GeneProduct825 (Entrez Gene) CAPN3; calpain 3 (p94) [EC:]
ITGB1GeneProduct3688 (Entrez Gene)
CAPN5GeneProduct726 (Entrez Gene) CAPN5; calpain
ITGB3GeneProduct3690 (Entrez Gene)
CAPN7GeneProduct23473 (Entrez Gene) CAPN7; calpain 7 [EC:
ITGB5GeneProduct3693 (Entrez Gene)
CAPN9GeneProduct10753 (Entrez Gene) CAPN9; calpain 9 (nCL-4) [EC:
ITGB7GeneProduct3695 (Entrez Gene)
CAPN10GeneProduct11132 (Entrez Gene) CAPN10; calpain 10 [EC:
VCLGeneProduct7414 (Entrez Gene) VCL; vinculin
CAPN11GeneProduct11131 (Entrez Gene) CAPN11; calpain 11 [EC:]
MAPK10GeneProduct5602 (Entrez Gene)
CAPN6GeneProduct827 (Entrez Gene) CAPN6; calpain 6 [EC:]
ILKGeneProduct3611 (Entrez Gene) ILK; integrin-linked kinase [EC:2.7.1.-]
PAK2GeneProduct5062 (Entrez Gene) PAK2; p21 (CDKN1A)-activated kinase 2 [EC:2.7.1.-]
VASPGeneProduct7408 (Entrez Gene) VASP; vasodilator-stimulated phosphoprotein
PAK3GeneProduct5063 (Entrez Gene) PAK3; p21 (CDKN1A)-activated kinase 3 [EC:2.7.1.-]
ITGA1GeneProduct3672 (Entrez Gene)
PAK4GeneProduct10298 (Entrez Gene) PAK4; p21(CDKN1A)-activated kinase 4 [EC:2.7.1.-]
MIR34CGeneProductENSG00000207562 (Ensembl)
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