Effects of PIP2 hydrolysis (Homo sapiens)

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Curation Tags

Description

Hydrolysis of phosphatidyl inositol-bisphosphate (PIP2) by phospholipase C (PLC) produces diacylglycerol (DAG) and inositol triphosphate (IP3). Both are potent second messengers. IP3 diffuses into the cytosol, but as DAG is a hydrophobic lipid it remains within the plasma membrane. IP3 stimulates the release of calcium ions from the smooth endoplasmic reticulum, while DAG activates the conventional and unconventional protein kinase C (PKC) isoforms, facilitating the translocation of PKC from the cytosol to the plasma membrane. The effects of DAG are mimicked by tumor-promoting phorbol esters. DAG is also a precursor for the biosynthesis of prostaglandins, the endocannabinoid 2-arachidonoylglycerol and an activator of a subfamily of TRP-C (Transient Receptor Potential Canonical) cation channels 3, 6, and 7.

Ontology Tags

 

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History

CompareRevisionActionTimeUserComment
42032view21:51, 4 March 2011MaintBotAutomatic update
39835view05:52, 21 January 2011MaintBotNew pathway

External references

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NameTypeDatabase referenceComment
Monoglyceride

lipase

ProteinQ99685 (UniProt)
1D-myo-Inositol

1,4,5-trisphosphate

Metabolite16595 (ChEBI)
IP3 receptor ComplexREACT_18961 (Reactome)
IP3 receptor bound

to IP3 and Ca++

ComplexREACT_4346 (Reactome)
Diacylglycerol kinase ProteinREACT_20449 (Reactome)
Calcium Metabolite29108 (ChEBI)
Glycerol Metabolite17754 (ChEBI)
CalDAG-GEFs ProteinREACT_18194 (Reactome) Rap1 can be activated by certain GEFs that respond to calcium and diacylglycerol (CalDAG-GEFs).
ADP Metabolite16761 (ChEBI)
1,2-

Diacylglycerol

Unknown17815 (ChEBI)
H2O Metabolite15377 (ChEBI)
Protein kinase C, novel

isoforms

ProteinREACT_22540 (Reactome) These isoforms of PKC bind DAG and phosphatidylserine (PS), but unlike the conventional forms, do not require calcium for PS binding.
Diacylglycerol

lipase

ProteinREACT_19676 (Reactome)
Protein kinase C,

novel isoforms:DAG

ComplexREACT_23271 (Reactome)
Arachidonate Metabolite15843 (ChEBI)
TRPC3/6/7 ProteinREACT_23108 (Reactome)
ATP Metabolite15422 (ChEBI)
DAG-activated

TRPC3/6/7

ComplexREACT_24061 (Reactome)
1,2-diacyl-glycerol 3-

phosphate

Unknown29089 (ChEBI)
2-Arachidonoylglycerol Metabolite52392 (ChEBI)
CalDAG-GEFs:

DAG:Ca2+

ComplexREACT_24405 (Reactome)
Fatty Acid UnknownREACT_19601 (Reactome)
H+ Metabolite15378 (ChEBI)
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