Apoptosis Modulation and Signaling (Homo sapiens)

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Description

Apoptosis, or cell death program, can be activated by various mechanisms within the extrinsic and the intrinsic pathway. While activation of cell death receptors leads to the engagement of the extrinsic pathway, the intrinsic pathway is activated by mitochondria during cellular stress, both

resulting in an activation of caspases. In the present pathway we emphasized the activation of caspases by those two pathways in pancreatic cancer (PDAC) cells. Please notice, that PDAC cells are so called type-II cells. In these cells the activation of cell death receptors is not sufficient to activated caspases. By cleavage of Bid, type-II cells activate the intrinsic pathway as "amplification loop".

Comments

GenMAPP notes 
Rückert F et al. Examination of Apoptosis Signaling in Pancreatic Cancer by Computational Signal Transduction Analysis.

PLoS ONE, 2010. 5: e12243

GenMAPP remarks 
Arrows: activation, broken arrows: inhibtion

Ontology Tags

 

Bibliography

  1. Rückert F, Dawelbait G, Winter C, Hartmann A, Denz A, Ammerpohl O, Schroeder M, Schackert HK, Sipos B, Klöppel G, Kalthoff H, Saeger HD, Pilarsky C, Grützmann R; ''Examination of apoptosis signaling in pancreatic cancer by computational signal transduction analysis.''; PLoS One, 2010 PubMed

History

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CompareRevisionActionTimeUserComment
63162view20:24, 8 May 2013MaintBotUpdating GPML version
44957view12:39, 6 October 2011MartijnVanIerselOntology Term : 'apoptotic cell death pathway' added !
42308view17:21, 16 March 2011KhanspersReverted to version '23:30, 1 March 2011' by Khanspers
42307view16:56, 15 March 2011Frances55Apoptosis Modulation and Signaling (Homo sapiens
41111view23:30, 1 March 2011Khanspers
40443view22:59, 25 February 2011Khansperstest
39652view13:15, 7 January 2011Felix555Design
39651view13:14, 7 January 2011Felix555Modified categories
39624view19:39, 4 January 2011KhanspersModified categories
39608view13:01, 30 December 2010Felix555New design
39607view12:53, 30 December 2010Felix555New design
39606view12:42, 30 December 2010Felix555Database connotations
39604view11:31, 30 December 2010Felix555Periodical save, work in progress
39603view11:09, 30 December 2010Felix555Periodical save, work in progress
39596view13:55, 29 December 2010Felix555Specify description
39595view13:54, 29 December 2010Felix555Bibliography
39594view13:49, 29 December 2010Felix555Modified description
39593view13:48, 29 December 2010Felix555...
39592view13:47, 29 December 2010Felix555New pathway

External references

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NameTypeDatabase referenceComment
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NoxaGeneProductPMAIP1 (HGNC)
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