TP53 Network (Homo sapiens)

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Description

P53 is not a lonely genome guardian, it operates with the assistance of p73 and p63 within a complex network including distinct but complementary pathways. This protein family presents a high level of sequence homology in its DNA binding domain. The complexity of the family has been enriched by the alternatively spliced forms of the genes. At present pathway, the alternatively spliced forms of p63 and p73 and how they interact with p53 are shown . However, little is known about the transcriptional regulation of p53 family members. Further studies will tell us whether the three genes of the family also share others regulatory activities.

Ontology Tags

 

Bibliography

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  1. Ishimoto O, Kawahara C, Enjo K, Obinata M, Nukiwa T, Ikawa S; ''Possible oncogenic potential of DeltaNp73: a newly identified isoform of human p73.''; Cancer Res, 2002 PubMed
  2. Bunt J, de Haas TG, Hasselt NE, Zwijnenburg DA, Koster J, Versteeg R, Kool M; ''Regulation of Cell Cycle Genes and Induction of Senescence by Overexpression of OTX2 in Medulloblastoma Cell Lines.''; Mol Cancer Res, 2010 PubMed
  3. Shaul Y; ''c-Abl: activation and nuclear targets.''; Cell Death Differ, 2000 PubMed
  4. Yang A, Kaghad M, Wang Y, Gillett E, Fleming MD, Dötsch V, Andrews NC, Caput D, McKeon F; ''p63, a p53 homolog at 3q27-29, encodes multiple products with transactivating, death-inducing, and dominant-negative activities.''; Mol Cell, 1998 PubMed
  5. Dohn M, Zhang S, Chen X; ''p63alpha and DeltaNp63alpha can induce cell cycle arrest and apoptosis and differentially regulate p53 target genes.''; Oncogene, 2001 PubMed
  6. Yuan ZM, Shioya H, Ishiko T, Sun X, Gu J, Huang YY, Lu H, Kharbanda S, Weichselbaum R, Kufe D; ''p73 is regulated by tyrosine kinase c-Abl in the apoptotic response to DNA damage.''; Nature, 1999 PubMed

History

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CompareRevisionActionTimeUserComment
71700view19:51, 17 October 2013MaintBotUpdated data sources
70104view18:54, 12 July 2013MaintBotupdated to 2013 schema
70032view01:57, 12 July 2013AlexanderPicoModified title
59109view22:22, 21 February 2013MaintBotUpdated Ensembl data source
48062view18:41, 1 May 2012KhanspersReplaced special characters
48060view18:14, 1 May 2012KhanspersPeriodical save, work in progress
45074view20:17, 6 October 2011KhanspersOntology Term : 'cancer' added !
45073view20:16, 6 October 2011KhanspersOntology Term : 'p53 signaling pathway' added !
41057view23:17, 1 March 2011MaintBotRemoved redundant pathway information and comments
39274view22:33, 9 November 2010AlexanderPicoModified categories
39273view22:32, 9 November 2010AlexanderPicoconnected line from SUMO-1 to TP53
39272view22:30, 9 November 2010AlexanderPicospecified xref systems, e.g., Entrez, UniProt or Ensembl
39264view11:17, 8 November 2010GlendaPeriodical save, work in progress
39263view10:56, 8 November 2010GlendaPeriodical save, work in progress
39262view10:36, 8 November 2010GlendaPeriodical save, work in progress
39261view09:54, 8 November 2010GlendaPeriodical save, work in progress
39260view09:43, 8 November 2010GlendaPeriodical save, work in progress
39205view07:57, 28 October 2010GlendaPeriodical save, work in progress
39204view07:47, 28 October 2010GlendaPeriodical save, work in progress
39203view07:10, 28 October 2010GlendaModified description
39202view05:03, 28 October 2010GlendaModified description
39197view14:05, 27 October 2010GlendaPeriodical save, work in progress
39196view13:49, 27 October 2010GlendaPeriodical save, work in progress
39195view13:38, 27 October 2010GlendaPeriodical save, work in progress
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39172view07:02, 27 October 2010GlendaPeriodical save, work in progress
39168view10:13, 26 October 2010GlendaPeriodical save, work in progress
39163view07:37, 26 October 2010Glendawork in progress
39151view14:03, 22 October 2010GlendaPeriodical save, work in progress

External references

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NameTypeDatabase referenceComment
BIDGeneProductENSG00000015475 (Ensembl)
ATMGeneProductENSG00000149311 (Ensembl)
BBC3GeneProduct27113 (Entrez Gene)
ABL1GeneProduct25 (Entrez Gene)
MDM2GeneProductENSG00000135679 (Ensembl)
TP73zetaProteinO15350 (Uniprot-TrEMBL)
IGFBP-3GeneProductHs.146732 (UniGene)
BAXGeneProduct581 (Entrez Gene)
DeltaNp63gammaProteinQ9H3D4 (Uniprot-TrEMBL)
TP73betaProteinO15350 (Uniprot-TrEMBL)
SUMO-1Protein7341 (Entrez Gene)
DeltaNp63betaProteinQ9H3D4 (Uniprot-TrEMBL)
BOKGeneProduct666 (Entrez Gene)
TAp63alphaProteinQ9H3D4 (Uniprot-TrEMBL)
OTX2GeneProductENSG00000165588 (Ensembl)
TP73deltaProteinO15350 (Uniprot-TrEMBL)
TP73alphaProteinO15350 (Uniprot-TrEMBL)
TP53GeneProduct7157 (Entrez Gene)
TAp63betaProteinQ9H3D4 (Uniprot-TrEMBL)
MYCGeneProduct4609 (Entrez Gene)
GADD45AGeneProduct1647 (Entrez Gene)
TAp63gammaProteinQ9H3D4 (Uniprot-TrEMBL)
PMAIP1GeneProduct5366 (Entrez Gene)
TP73 Delta Np73ProteinO15350 (Uniprot-TrEMBL)
CDKN2AGeneProduct1029 (Entrez Gene)
TP63GeneProduct8626 (Entrez Gene)
CDKN1AGeneProductENSG00000124762 (Ensembl)
TP73gammaProteinO15350 (Uniprot-TrEMBL)
TP73GeneProduct7161 (Entrez Gene)
TP73epsilonProteinO15350 (Uniprot-TrEMBL)
TNFSF10GeneProduct8743 (Entrez Gene)
DelatNp63alphaProteinQ9H3D4 (Uniprot-TrEMBL)
BCL2GeneProductENSG00000171791 (Ensembl)
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