Eicosanoid Synthesis (Homo sapiens)

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In biochemistry, eicosanoids are signaling molecules made by oxidation of twenty-carbon essential fatty acids, (EFAs). They exert complex control over many bodily systems, mainly in inflammation or immunity, and as messengers in the central nervous system. Source: Wikipedia

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  1. Funk CD; ''Prostaglandins and leukotrienes: advances in eicosanoid biology.''; Science, 2001 PubMed


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82702view07:46, 23 October 2015EgonwReplaced to CAS numbers with the ChEBI identifiers: 70608-72-9 cannot be 5-HETE, 12-HETE, and 15-HETE at the same time.
79809view16:44, 16 April 2015Mkutmonfixed unconnected line
71381view18:40, 17 October 2013MaintBotAutomated update of data sources
67184view10:17, 26 June 2013Christine ChichesterOntology Term : 'eicosanoid biosynthetic pathway' added !
63178view20:30, 8 May 2013MaintBotUpdating gpml version
45234view17:44, 7 October 2011AlexanderPicoOntology Term : 'epithelial cell' added !
45226view17:36, 7 October 2011AlexanderPicoOntology Term : 'inflammatory response pathway' added !
45138view01:00, 7 October 2011AlexanderPicofixed reaction
45103view22:21, 6 October 2011AlexanderPicofixed reactions
45099view21:51, 6 October 2011AlexanderPicoupdated reactions
45098view21:46, 6 October 2011AlexanderPicoupdated refs and reactions
45095view21:16, 6 October 2011AlexanderPicodb refs
41942view18:41, 2 March 2011CarlospirolaPNPLA3 added
41939view17:39, 2 March 2011CarlospirolaPeriodical save, work in progress
41143view23:39, 1 March 2011MaintBotRemoved redundant pathway information and comments
35467view12:07, 12 February 2010Thomasadded literature
35466view12:06, 12 February 2010ThomasModified description
34433view18:14, 10 December 2009MaintBotAutomatic update of empty xrefs
31982view13:11, 14 August 2009MaintBotFixed group labels
21031view11:30, 14 November 2008MaintBot[[Pathway:Homo sapiens:Eicosanoid Synthesis]] moved to [[Pathway:WP167]]: Moved to stable identifier
15401view22:56, 27 May 2008Khanspersconnectors and metabolites
15399view22:53, 27 May 2008KhanspersPeriodical save, work in progress
15397view22:43, 27 May 2008KhanspersPeriodical save, work in progress
13058view11:12, 17 May 2008MaintBotautomated metabolite conversion
8002view13:46, 7 January 2008MaintBot[[Pathway:Human:Eicosanoid Synthesis]] moved to [[Pathway:Homo sapiens:Eicosanoid Synthesis]]: Renaming species
7624view16:05, 18 December 2007MaintBotfixed category names
7337view12:42, 4 November 2007MaintBotAdded categories to GPML
6310view22:17, 22 May 2007A.Kwagpml file for [[Human:Eicosanoid_Synthesis]]

External references

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NameTypeDatabase referenceComment
Prostaglandin H2MetaboliteHMDB01381 (HMDB)
PLA2G2AGeneProduct5320 (Entrez Gene)
PLA2G6GeneProduct8398 (Entrez Gene)
Prostaglandin I2MetaboliteHMDB01335 (HMDB)
ALOX5APGeneProduct241 (Entrez Gene)
Arachidonic acidMetaboliteHMDB01043 (HMDB)
ALOX5GeneProduct240 (Entrez Gene)
Leukotriene B4MetaboliteHMDB01085 (HMDB)
ALOX15GeneProduct246 (Entrez Gene)
Prostaglandin E2Metabolite363-24-6 (CAS)
PeroxidaseGeneProduct1.11.1.7 (Enzyme Nomenclature)
12-HETEMetaboliteCHEBI:19138 (ChEBI)
DPEP1GeneProduct1800 (Entrez Gene)
Thromboxane B2MetaboliteHMDB03252 (HMDB)
PTGISGeneProduct5740 (Entrez Gene)
Prostaglandin F2aMetaboliteHMDB01139 (HMDB)
ALOX12GeneProduct239 (Entrez Gene)
Leukotriene D4MetaboliteHMDB03080 (HMDB)
ALOX15BGeneProduct247 (Entrez Gene)
12-HPETEMetabolite71030-35-8 (CAS)
PTGS1GeneProduct5742 (Entrez Gene)
dehydrogenaseGeneProduct1.1.1.231 (Enzyme Nomenclature)
PTGS2GeneProduct5743 (Entrez Gene)
15-HETEMetaboliteCHEBI:64017 (ChEBI)
TBXAS1GeneProduct6916 (Entrez Gene)
5-HETEMetabolite70608-72-9 (CAS)
LTC4SGeneProduct4056 (Entrez Gene)
5-HPETEMetaboliteHMDB01193 (HMDB)
GGT1GeneProduct2678 (Entrez Gene)
Thromboxane A2MetaboliteHMDB01452 (HMDB)
GSH peroxidaseGeneProduct1.11.1.9 (Enzyme Nomenclature)
Prostaglandin D2MetaboliteHMDB01403 (HMDB)
PNPLA8GeneProduct50640 (Entrez Gene)
Leukotriene A4MetaboliteHMDB01337 (HMDB)
LTA4HGeneProduct4048 (Entrez Gene)
Leukotriene C4MetaboliteHMDB01198 (HMDB)
PGE2 9-ketoreducGeneProduct1.1.1.189 (Enzyme Nomenclature)
Leukotriene E4MetaboliteHMDB02200 (HMDB)
PTGESGeneProduct9536 (Entrez Gene)
PTGES2GeneProduct80142 (Entrez Gene)
15-HPETEMetabolite70981-96-3 (CAS)
PTGDSGeneProduct5730 (Entrez Gene)
15-oxo-prostaglandin I2Metabolite
PGD2 11-ketoreducGeneProduct1.1.1.188 (Enzyme Nomenclature)
Thromboxane A3Metabolite
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