Vitamin B12 Metabolism (Homo sapiens)

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History

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CompareRevisionActionTimeUserComment
70117view19:15, 12 July 2013MaintBotupdated to 2013 schema
69054view18:01, 8 July 2013EgonwReplaced an outdated HMDB identifier with the 3.5 one.
68769view16:12, 7 July 2013EgonwFixed the fibrin PubChem-compound data source name, Wikipedia identifier, and Enzyme Nomenclature data source names.
49537view09:35, 20 July 2012AndraCorrected Identifier error found in Rdf export
48238view06:00, 17 May 2012MaintBotUpdating PubChem xrefs
45013view18:13, 6 October 2011KhanspersOntology Term : 'pernicious anemia' added !
45012view18:07, 6 October 2011KhanspersOntology Term : 'Vitamin B12 (cobalamin) metabolic pathway' added !
41028view23:13, 1 March 2011MaintBotRemoved redundant pathway information and comments
39775view21:34, 17 January 2011AlexanderPicomore complete title
38840view17:36, 24 September 2010KhanspersAdded pathway links, changed line types
38839view17:34, 24 September 2010KhanspersPeriodical save, work in progress
37210view20:44, 21 May 2010KhanspersModified categories
37066view15:02, 15 May 2010DamarizEnd
37065view15:00, 15 May 2010DamarizFructosamine
37064view14:58, 15 May 2010DamarizHBA1
37063view14:54, 15 May 2010DamarizPAI-1
37062view14:52, 15 May 2010DamarizPeriodical save, work in progress
37061view14:50, 15 May 2010Damarizalb(2)
37060view14:46, 15 May 2010Damarizalb
37059view14:40, 15 May 2010DamarizINS
37058view14:36, 15 May 2010Damariztpa
37057view14:30, 15 May 2010DamarizCreatinine(2)
37056view14:26, 15 May 2010DamarizCreatinine
37055view14:20, 15 May 2010Damarizfactor VII
37054view14:16, 15 May 2010Damarizplg
37053view14:10, 15 May 2010Damarizoxldl
37052view14:06, 15 May 2010DamarizLDL
37051view14:03, 15 May 2010Damarizadenosylcobalamin
37050view14:01, 15 May 2010DamarizPeriodical save, work in progress
37049view13:59, 15 May 2010DamarizNADP
37048view13:55, 15 May 2010DamarizNadph
37047view13:50, 15 May 2010DamarizPeriodical save, work in progress
37046view09:52, 15 May 2010Damarizvitamin d(2)
37045view09:51, 15 May 2010Damarizvitamin d
37044view09:48, 15 May 2010Damarizriboflavin
37043view09:45, 15 May 2010Damarizs-adenosyl(2)
37042view09:42, 15 May 2010Damarizzinc(2)
37041view09:39, 15 May 2010Damariz5-methyl-THF(2)
37040view09:35, 15 May 2010Damarizs-adenosyl
37039view09:34, 15 May 2010Damarizzinc
37038view09:33, 15 May 2010Damariz5-methyl-THF
37037view09:28, 15 May 2010DamarizPeriodical save, work in progress
37036view09:26, 15 May 2010DamarizS-adenosyl(2)
37035view09:23, 15 May 2010DamarizMethylcob (2)
37034view09:21, 15 May 2010DamarizHomocysteine(2)
37033view09:18, 15 May 2010DamarizS-Adenosyl
37032view09:17, 15 May 2010DamarizMethylcob
37031view09:16, 15 May 2010DamarizHomocysteine
37030view09:12, 15 May 2010DamarizPyridoxal(2)
37029view09:10, 15 May 2010DamarizChlorine(2)

External references

View all...
NameTypeDatabase referenceComment
L-Methylmalonyl-CoAMetaboliteHMDB01269 (HMDB)
IF*GeneProduct2694 (Entrez Gene)
  • gastric intrinsic factor (vitamin B synthesis)
  • Also known as GIF
O3Metabolite25812 (ChEBI) ozone
HCGeneProduct6947 (Entrez Gene)
  • Haptocorrin
  • transcobalamin I (vitamin B12 binding protein, R binder family)
VLDL-TAGMetabolite47776 (ChEBI)
  • very-low-density lipoprotein-triglyceride
  • Triglyceride transport
CUBNGeneProduct8029 (Entrez Gene) cubilin (intrinsic factor-cobalamin receptor)
TNFaProtein7124 (Entrez Gene) tumor necrosis factor (TNF superfamily, member 2)
TCN2*GeneProduct6948 (Entrez Gene) transcobalamin II; macrocytic anemia
HDL/SAAMetabolite39025 (ChEBI)
  • high-density lipoprotein
  • SAA circulates in plasma as a constituent of high density lipoproteins (HDL).
MegalinGeneProduct4036 (Entrez Gene) Low density lipoprotein receptor-related protein 2
8-OHdGMetaboliteHMDB03333 (HMDB) 8-Hydroxy-deoxyguanosine
MCP1GeneProduct6347 (Entrez Gene)
  • Monocyte Chemotactic Protein 1
  • CCL2
D-dimerProteinFibrin_degradation_product (Wikipedia) http://en.wikipedia.org/wiki/Fibrin_degradation_product
RELAGeneProduct5970 (Entrez Gene) nuclear factor of kappa light polypeptide gene enhancer in B-cells 3, p65
S-AdenosylhomocysteineMetaboliteHMDB00939 (HMDB)
NFkB1GeneProduct4790 (Entrez Gene) nuclear factor NF-kappa-B p50 subunit
LDL-CMetabolite47774 (ChEBI)
  • low-density lipoprotein cholesterol
NFkB2GeneProduct4791 (Entrez Gene) nuclear factor of kappa light polypeptide gene enhancer in B-cells 2
APOEProtein348 (Entrez Gene) apolipoprotein A-I
PGF2aMetaboliteHMDB01139 (HMDB) Prostaglandin F2a
FADMetaboliteHMDB01248 (HMDB) Flavin adenine dinucleotide
Thromboxane A2MetaboliteHMDB01452 (HMDB)
SOD2Protein6648 (Entrez Gene)
  • EC 1.15.1.1
  • superoxide dismutase 2, mitochondrial
Thromboxane B2MetaboliteHMDB03252 (HMDB)
N2OMetabolite17045 (ChEBI)
  • Dinitrogen oxide
  • Nitrous oxide
PGE1MetaboliteHMDB01442 (HMDB) Prostaglandin E1
ALBProtein213 (Entrez Gene) albumin
PGE2MetaboliteHMDB01220 (HMDB) Prostaglandin E2
IL6Protein3569 (Entrez Gene) interleukin 6 (interferon, beta 2)
a-TocopherolMetaboliteHMDB01893 (HMDB) Vitamin E
Cbl/HCMetaboliteHMDB02174 (HMDB) Cobalamin haptocorrin complex
F2-IsoprostaneMetabolite53788444 (PubChem-substance)
FructosamineMetaboliteHMDB02030 (HMDB)
8-Isoprostaglandin F2aMetaboliteHMDB05083 (HMDB)
SAA3Protein6290 (Entrez Gene) serum amyloid A3 pseudogene
Prostaglandin metabolismPathway
SRB1Protein949 (Entrez Gene) scavenger receptor class B, member 1
DNA OxidationPathway
VLDL/APOBMetabolite39027 (ChEBI)
  • very-low-density lipoprotein
  • The VLDL is produced in the liver, contains one molecule of apoB100
Lipid peroxidationPathway
Cob(II)alaminMetaboliteHMDB06316 (HMDB) oxidized cobalamin
Lipoprotein metabolismPathway
AdenosylcobalaminMetaboliteHMDB02086 (HMDB)
Protein tyrosine nitrationPathway
vitamin DMetabolite27300 (ChEBI)
MSR*Protein4552 (Entrez Gene)
  • EC 1.16.1.8
  • 5-methyltetrahydrofolate-homocysteine methyltransferase reductase
HOClMetaboliteHMDB01050 (HMDB) Hypochlorite
MTR*Protein4548 (Entrez Gene)
  • EC 2.1.1.13
  • 5-methyltetrahydrofolate-homocysteine methyltransferase
  • Also known as MS
HNO2Metabolite25567 (ChEBI) Nitrous acid
MATProtein4143 (Entrez Gene)
  • EC 2.5.1.6
  • Methionine adenosyltransferase
sICAM-1Protein3383 (Entrez Gene) soluble intercellular adhesion molecule 1
MUTProtein4594 (Entrez Gene)
  • EC 5.4.99.2
  • methylmalonyl Coenzyme A mutase
  • Also known as MCM
INSRProtein3643 (Entrez Gene) Insulin receptor
MMABProtein326625 (Entrez Gene)
  • EC 2.5.1.17
  • methylmalonic aciduria (cobalamin deficiency) cblB type
  • Also known as ATR
HbA1cProteinGlycated_hemoglobin (Wikipedia)
  • Glycated hemoglobin
  • http://en.wikipedia.org/wiki/Glycated_hemoglobin
SHMTProtein6472 (Entrez Gene)
  • EC 2.1.2.1
  • Serine hydroxymethyltransferase
IL1BProtein3553 (Entrez Gene) interleukin 1, beta
CBRProtein1.16.1.4 (Enzyme Nomenclature)
  • EC 1.16.1.4
  • cob(II)alamin reductase
O2MetaboliteHMDB02168 (HMDB) Superoxide
MM-CoA-HProtein3.1.2.17 (Enzyme Nomenclature)
  • EC 3.1.2.17
  • (S)-methylmalonyl-CoA hydrolase
D-Methylmalonyl-CoAMetaboliteHMDB01269 (HMDB)
MCEEProtein84693 (Entrez Gene)
  • EC 5.1.99.1
  • methylmalonyl CoA epimerase
Cbl/TCMetaboliteHMDB02174 (HMDB) Cobalamin Transcobalamin complex
CBSProtein875 (Entrez Gene)
  • EC 4.2.1.22
  • cystathionine-beta-synthase
NitrotyrosineMetaboliteHMDB01904 (HMDB)
NADP+MetaboliteHMDB00217 (HMDB) Nicotinamide adenine dinucleotide phosphate-Oxidized
Protein
NADHMetaboliteHMDB01487 (HMDB) Reduced nicotinamide adenine diphosphate
SAA1Protein6288 (Entrez Gene) serum amyloid A1
MPOProtein4353 (Entrez Gene)
  • EC 1.11.1.7
  • Myeloperoxidase
SAA2Protein6289 (Entrez Gene) serum amyloid A2
CysteineMetaboliteHMDB00574 (HMDB)
SAA4Protein6291 (Entrez Gene) serum amyloid A4, constitutive
ThrombinProtein2147 (Entrez Gene)
  • EC 3.4.21.5
  • coagulation factor II (thrombin)
ABCA1Protein19 (Entrez Gene) ATP-binding cassette, sub-family A (ABC1), member 1
PLGProtein5340 (Entrez Gene)
  • EC 3.4.21.7
  • Plasminogen
ACTProtein12 (Entrez Gene)
  • alpha-1-antichymotrypsin
  • serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
Factor VIIProtein2155 (Entrez Gene)
  • EC 3.4.21.21
  • coagulation factor VII (serum prothrombin conversion accelerator)
TAGMetabolite17855 (ChEBI)
  • Triglyceride
  • Triacylglycerol
PAI-1Protein5054 (Entrez Gene) Serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
VLDLMetabolite39027 (ChEBI) very-low-density lipoprotein
tPAProtein5327 (Entrez Gene)
  • EC 3.4.21.68
  • plasminogen activator, tissue
Cob(I)alaminMetaboliteHMDB03429 (HMDB) Reduced cobalamin
H2O2MetaboliteHMDB03125 (HMDB) Hydrogen peroxide
Methylcob(III)alaminMetaboliteHMDB02274 (HMDB)
5,10-Methylene-THFMetaboliteHMDB01533 (HMDB) 5,10-Methylenetetrahydrofolate
Vitamin B12/CobalaminMetaboliteHMDB02174 (HMDB)
5-methyl-THFMetaboliteHMDB01396 (HMDB)
  • 5-methyltetrahydrofolate
  • Predominant food folate
ChlorineMetaboliteHMDB00492 (HMDB)
CreatinineMetaboliteHMDB00562 (HMDB)
  • Creatine anhydride
  • A breakdown product of creatine phosphate in muscle
CystathionineMetaboliteHMDB00099 (HMDB)
SOD3Protein6649 (Entrez Gene)
  • EC 1.15.1.1
  • superoxide dismutase 3, extracellular
ZincMetaboliteHMDB01303 (HMDB)
CTHProtein1491 (Entrez Gene)
  • EC 4.4.1.1
  • cystathionase
NOMetaboliteHMDB03378 (HMDB) Nitric oxide
THFMetaboliteHMDB01846 (HMDB) Tetrahydrofolic acid
NO2Metabolite33101 (ChEBI) Nitrogen dioxide
NADPHMetaboliteHMDB00221 (HMDB) Nicotinamide adenine dinucleotide phosphate-Reduced
NO3-MetaboliteHMDB02878 (HMDB) Nitrate
NADMetaboliteHMDB00902 (HMDB) Nicotinamide adenine dinucleotide
CRPProtein1401 (Entrez Gene) C-reactive protein, pentraxin-related
MTHFR*Protein4524 (Entrez Gene)
  • EC 1.5.1.20
  • 5,10-methylenetetrahydrofolate reductase
  • Homozygous of (MTHFR) 677C-T variant may have enzyme activities up to 50% lower than those without the polymorphism increasing the risk of hyperhomocysteinemia
FibrinogenProteinGO:0005577 (Other)
HomocysteineMetaboliteHMDB00742 (HMDB)
FibrinProtein439199 (PubChem-compound)
SOD1Protein6647 (Entrez Gene)
  • EC 1.15.1.1
  • superoxide dismutase 1, soluble
INSProtein3630 (Entrez Gene) Insulin
Pyridoxal 5'-phosphateMetaboliteHMDB01491 (HMDB) Vitamin B6
HBBProtein3043 (Entrez Gene) hemoglobin, beta
SerineMetaboliteHMDB00187 (HMDB)
HBA1Protein3039 (Entrez Gene) hemoglobin, alpha 1
APOA1-NO2TyrProtein335 (Entrez Gene) Nitrotyrosinated apolipoprotein A-I
RANTESProtein6352 (Entrez Gene)
  • CCL5
  • chemokine (C-C motif) ligand 5
HDLMetabolite39025 (ChEBI) high-density lipoprotein
IL10Protein3458 (Entrez Gene) interferon, gamma
APOA1Protein335 (Entrez Gene) apolipoprotein A-I
RiboflavinMetaboliteHMDB00244 (HMDB)
HDL-CMetabolite47775 (ChEBI)
  • high-density lipoprotein cholesterol
  • Cholesterol transport
MethionineMetaboliteHMDB00696 (HMDB)
HDL/APOA1Metabolite39025 (ChEBI)
  • high-density lipoprotein
  • ApoA-I is present on the majority of HDL particles and constitutes aprox 70% of the apolipoprotein content of HDL particles
S-AdenosylmethionineMetaboliteHMDB01185 (HMDB)
CholesterolMetaboliteHMDB00067 (HMDB)
Succinyl-CoAMetaboliteHMDB01022 (HMDB)
oxLDLMetabolite39026 (ChEBI) oxidized low-density lipoprotein
Cbl/IFMetaboliteHMDB02174 (HMDB) Cobalamin Intrinsic factor complex
LDLRProtein3949 (Entrez Gene) low density lipoprotein receptor
Methylmalonic acidMetaboliteHMDB00202 (HMDB) Methylmalonate
LDLMetabolite39026 (ChEBI) low-density lipoprotein
ONOO-ONOOHMetaboliteHMDB02179 (HMDB) Peroxynitrite
APOBProtein338 (Entrez Gene) apolipoprotein B
GlucoseMetaboliteHMDB00122 (HMDB)
LDL/APOBMetabolite39026 (ChEBI)
  • low-density lipoprotein
  • LDL particle contains 1 molecule of apo B
Ascorbic acidMetabolite29073 (ChEBI) Vitamin C
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