estrogen signalling (Danio rerio)

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Curation Tags

Description

Estrogen receptor refers to a group of receptors which are activated by the hormone 17β-estradiol (estrogen). Two types of estrogen receptor exist: ER which is a member of the nuclear hormone family of intracellular receptors and the estrogen G protein coupled receptor GPR30 (GPER), which is a G-protein coupled receptor. The main function of the estrogen receptor is as a DNA binding transcription factor which regulates gene expression. However the estrogen receptor also has additional functions independent of DNA binding.


Comments

HomologyConvert 
This pathway was inferred from Homo sapiens pathway WP712(r29739) with a 81% conversion rate.

Bibliography

  1. Song YJ, Jen KY, Soni V, Kieff E, Cahir-McFarland E; ''IL-1 receptor-associated kinase 1 is critical for latent membrane protein 1-induced p65/RelA serine 536 phosphorylation and NF-kappaB activation.; ''Proc Natl Acad Sci U S A, 2006 - PubMed
  2. Battaglia F, Delfino S, Merello E, Puppo M, Piva R, Varesio L, Bosco MC; ''Hypoxia transcriptionally induces macrophage-inflammatory protein-3alpha/CCL-20 in primary human mononuclear phagocytes through nuclear factor (NF)-kappaB.; ''J Leukoc Biol, 2008 - PubMed
  3. Uemura N, Kajino T, Sanjo H, Sato S, Akira S, Matsumoto K, Ninomiya-Tsuji J; ''TAK1 is a component of the Epstein-Barr virus LMP1 complex and is essential for activation of JNK but not of NF-kappaB.; ''J Biol Chem, 2006 - PubMed

Categories

History

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34184view21:22, 9 December 2009MaintBotAutomatic update of empty xrefs
32319view13:24, 15 August 2009MaintBotFixed text labels
31920view12:52, 14 August 2009MaintBotFixed group labels
31354view20:32, 13 August 2009MaintBotFixed text labels
31040view01:18, 30 July 2009MaintBotNew pathway

Pathway Info

DataNodes

View all 76 DataNodes

Name Type Backpage Header Database reference
creb1GeneProductcreb1573207 (Entrez Gene)
si:dkey-94n12.3GeneProductsi:dkey-94n12.3562011 (Entrez Gene)
ep300aGeneProductep300a559273 (Entrez Gene)
hdac3GeneProducthdac3393965 (Entrez Gene)
crebbpbGeneProductcrebbpb503776 (Entrez Gene)
srcGeneProductsrc325084 (Entrez Gene)
zgc:110584GeneProductzgc:110584798997 (Entrez Gene)
fosGeneProductfos394198 (Entrez Gene)
tbpGeneProducttbp368882 (Entrez Gene)
HDAC2GeneProduct
ilkGeneProductilk393543 (Entrez Gene)
LOC567895GeneProductLOC567895567895 (Entrez Gene)
gtf2h2GeneProductgtf2h2323239 (Entrez Gene)
LOC792354GeneProductLOC792354792354 (Entrez Gene)
gtf2e2GeneProductgtf2e2334854 (Entrez Gene)
chukGeneProductchukENSDARG00000011662 (Ensembl Zebrafish)
ercc2GeneProductercc2393900 (Entrez Gene)
gperGeneProductgper565271 (Entrez Gene)
mnat1GeneProductmnat1450080 (Entrez Gene)
hdac1GeneProducthdac1192302 (Entrez Gene)
TAF12GeneProducttaf12386637 (Entrez Gene)
SIN3GeneProduct
taf9GeneProducttaf9321485 (Entrez Gene)
brafGeneProductbraf403065 (Entrez Gene)
gtf2bGeneProductgtf2b324823 (Entrez Gene)
grb2GeneProductgrb2406308 (Entrez Gene)
taf5GeneProducttaf5641491 (Entrez Gene)
LOC100149273GeneProductLOC100149273100149273 (Entrez Gene)
taf6GeneProducttaf6447818 (Entrez Gene)
EstradiolMetabolite5757 (PubChem)
taf7GeneProducttaf7100002261 (Entrez Gene)
ikbkbGeneProductikbkbENSDARG00000079123 (Ensembl Zebrafish)
GTF2H3GeneProductgtf2h3436837 (Entrez Gene)
sp1GeneProductsp1324109 (Entrez Gene)
GTF2F2GeneProductgtf2f2415217 (Entrez Gene)
GNB1GeneProductgnb1322104 (Entrez Gene)
taf13GeneProducttaf13324153 (Entrez Gene)
esr1GeneProductesr1259252 (Entrez Gene)
ercc3GeneProductercc3324323 (Entrez Gene)
hdac6GeneProducthdac6565482 (Entrez Gene)
cdk7GeneProductcdk7405897 (Entrez Gene)
HDAC7AGeneProduct
si:ch211-194d6.2GeneProductsi:ch211-194d6.2567899 (Entrez Gene)
hdac8GeneProducthdac8406740 (Entrez Gene)
ccnhGeneProductccnh541325 (Entrez Gene)
ccnd1GeneProductccnd130222 (Entrez Gene)
gtf2h4GeneProductgtf2h4334839 (Entrez Gene)
mapk1GeneProductmapk1ENSDARG00000027552 (Ensembl Zebrafish)
zgc:92126GeneProductzgc:92126447857 (Entrez Gene)
RASGeneProduct
polr2eGeneProductpolr2e445170 (Entrez Gene)
map2k1GeneProductmap2k1ENSDARG00000007825 (Ensembl Zebrafish)
LOC792188GeneProductLOC792188792188 (Entrez Gene)
SOSGeneProduct
LOC100149268GeneProductLOC100149268100149268 (Entrez Gene)
mapk14aGeneProductmapk14a65237 (Entrez Gene)
LOC791979GeneProductLOC791979791979 (Entrez Gene)
LOC561737GeneProductLOC561737561737 (Entrez Gene)
LOC792258GeneProductLOC792258792258 (Entrez Gene)
Cyclic AMPMetabolite6076 (PubChem)
polr2jGeneProductpolr2j554099 (Entrez Gene)
zgc:158799GeneProductzgc:158799564064 (Entrez Gene)
POLR2KGeneProduct
BCL2GeneProductbcl2570772 (Entrez Gene)
polr2glGeneProductpolr2gl324088 (Entrez Gene)
ikbkgGeneProductikbkgENSDARG00000017037 (Ensembl Zebrafish)
POLR2IGeneProduct
NFKBGeneProduct
polr2aGeneProductpolr2a553347 (Entrez Gene)
junGeneProductjun335916 (Entrez Gene)
ncor1GeneProductncor1393246 (Entrez Gene)
LOC557353GeneProductLOC557353557353 (Entrez Gene)
hdac4GeneProducthdac4568877 (Entrez Gene)
gngt1GeneProductgngt1335656 (Entrez Gene)
LOC557486GeneProductLOC557486557486 (Entrez Gene)
BRCA1GeneProduct
Retrieved from "http://www.wikipathways.org/index.php/Pathway:WP1330"
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