IL-5 Signaling Pathway (Homo sapiens)

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Description

Interleukin 5 (IL-5) ligand belongs to the cytokine superfamily. IL-5 is a glycoprotein which belongs to the cytokine superfamily. It possesses the four helical bundle motifs that is conserved among several hematopoietic cytokines. IL-5 plays an important role in the proliferation and differentiation of eosinophils. IL-5 induces terminal maturation of eosinophils, prolongs eosinophils survival by delaying apoptotic death, increases eosinophils adhesion to endothelial cells and enhances eosinophils effector function. IL-5 plays important roles in the pathogenesis of asthma, hypereosinophilic syndromes and eosinophil-dependent inflammatory diseases. IL-5 is produced by eosinophils, mast cells, Th2 cells, Tc2 cells and gamma delta T cells. IL-5 exerts influence on different biological activities by associating with the IL-5 receptor. This receptor is a heterodimeric complex consisting of an alpha chain-IL5RA and a beta chain, CSF2RB, which is shared between IL-5 receptor, IL-3 receptor and granulocyte macrophage colony stimulating factor receptor. Binding of IL-5 to the receptor complex results in the recruitment of adapter proteins including SHC1, GRB2 and SOS1. This leads to the activation of the Ras/Raf/MEK/ERK cascade. Subsequent activation of transcription factors including JUN and ELK-1 regulates the expression of genes involved in the control of cell growth and differentiation. IL-5 stimulation also resulted in the activation of PI3K/AKT/RPS6K pathway resulting in the phosphorylation of RPS6 and regulation of gene expression. JAK phosphorylation and activation is also brought about by IL-5, which in turn results in the activation and nuclear translocation of STAT proteins. The STAT transcription factors are responsible for the expression of early response genes and feedback inhibitor of JAK/STAT pathway. In addition, IL-5 is known to activate various tyrosine kinases such as LYN, BTK and SYK. The interactions and intersections between canonical and non-canonical IL-5 signaling systems are depicted in the pathway map.


Please access this pathway at NetSlim database.

If you use this pathway, you must cite following paper:

Kandasamy, K., Mohan, S. S., Raju, R., Keerthikumar, S., Kumar, G. S. S., Venugopal, A. K., Telikicherla, D., Navarro, J. D., Mathivanan, S., Pecquet, C., Gollapudi, S. K., Tattikota, S. G., Mohan, S., Padhukasahasram, H., Subbannayya, Y., Goel, R., Jacob, H. K. C., Zhong, J., Sekhar, R., Nanjappa, V., Balakrishnan, L., Subbaiah, R., Ramachandra, Y. L., Rahiman, B. A., Prasad, T. S. K., Lin, J., Houtman, J. C. D., Desiderio, S., Renauld, J., Constantinescu, S. N., Ohara, O., Hirano, T., Kubo, M., Singh, S., Khatri, P., Draghici, S., Bader, G. D., Sander, C., Leonard, W. J. and Pandey, A. (2010). NetPath: A public resource of curated signal transduction pathways. Genome Biology. 11:R3.

Ontology Tags

 

Bibliography

  1. Kandasamy K, Mohan SS, Raju R, Keerthikumar S, Kumar GS, Venugopal AK, Telikicherla D, Navarro JD, Mathivanan S, Pecquet C, Gollapudi SK, Tattikota SG, Mohan S, Padhukasahasram H, Subbannayya Y, Goel R, Jacob HK, Zhong J, Sekhar R, Nanjappa V, Balakrishnan L, Subbaiah R, Ramachandra YL, Rahiman BA, Prasad TS, Lin JX, Houtman JC, Desiderio S, Renauld JC, Constantinescu SN, Ohara O, Hirano T, Kubo M, Singh S, Khatri P, Draghici S, Bader GD, Sander C, Leonard WJ, Pandey A; ''NetPath: a public resource of curated signal transduction pathways.''; Genome Biol, 2010 PubMed

History

View all...
CompareRevisionActionTimeUserComment
70017view01:50, 12 July 2013AlexanderPicoModified title
68063view17:57, 29 June 2013MaintBotOntology Term : 'DOID:4' removed !
67853view12:34, 27 June 2013Noopur144Ontology Term : 'Disease' added !
67380view10:44, 26 June 2013Christine ChichesterOntology Term : 'interleukin-5 signaling pathway' added !
64648view15:03, 31 May 2013AndraAdded reference from the description in the pathway
63212view20:58, 8 May 2013MaintBotUpdating gpml version
48438view14:36, 24 May 2012NetPathModified description
45368view20:59, 7 October 2011AlexanderPicoOntology Term : 'DOID:8406' removed !
45132view00:52, 7 October 2011AlexanderPicofixed db refs
44847view09:47, 6 October 2011MartijnVanIerselOntology Term : 'Interleukin mediated signaling pathway' added !
44626view18:05, 22 September 2011KhanspersUpdating content to NetSlim
44104view20:23, 24 August 2011KhanspersReverted to version '23:13, 1 March 2011' by Khanspers
44021view22:48, 22 August 2011KhanspersAdded category
44020view22:48, 22 August 2011KhanspersModified description
44019view22:46, 22 August 2011KhanspersUpdating pathway from NetSlim
41029view23:13, 1 March 2011MaintBotRemoved redundant pathway information and comments
35644view21:34, 12 February 2010KhanspersModified description
20949view11:30, 14 November 2008MaintBot[[Pathway:Homo sapiens:IL-5 NetPath 17]] moved to [[Pathway:WP127]]: Moved to stable identifier
8182view13:46, 7 January 2008MaintBot[[Pathway:Human:IL-5 NetPath 17]] moved to [[Pathway:Homo sapiens:IL-5 NetPath 17]]: Renaming species
7711view16:12, 18 December 2007MaintBotfixed category names
7250view12:41, 4 November 2007MaintBotAdded categories to GPML
6338view22:18, 22 May 2007A.Pandeygpml file for [[Human:IL-5_NetPath_17]]

External references

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NameTypeDatabase referenceComment
CSF2RBProtein1439 (Entrez Gene)
STAT5AProtein6776 (Entrez Gene)
JUNProtein3725 (Entrez Gene)
RPS6KB1Protein6198 (Entrez Gene)
PIM1Rna2353 (Entrez Gene)
MAPK3Protein5595 (Entrez Gene)
SOS1Protein6654 (Entrez Gene)
AKT1Protein207 (Entrez Gene)
STAT1Protein6772 (Entrez Gene)
HRASProtein3845 (Entrez Gene)
IL5Protein3558 (Entrez Gene)
JAK1 Protein3716 (Entrez Gene)
FOSRna2353 (Entrez Gene)
JAK2Protein3717 (Entrez Gene)
MAP2K1Protein5604 (Entrez Gene)
LYNProtein4067 (Entrez Gene)
MAPK1Protein5594 (Entrez Gene)
PTPN11Protein5781 (Entrez Gene)
RPS6KB2Protein6199 (Entrez Gene)
PIK3R1Protein5295 (Entrez Gene)
STAT5BProtein6777 (Entrez Gene)
PIK3R2Protein5296 (Entrez Gene)
RPS6Protein6194 (Entrez Gene)
PIK3CGGeneProduct5294 (Entrez Gene)
BCL2Rna596 (Entrez Gene)
ELK1Protein2002 (Entrez Gene)
MTORProtein4137 (Entrez Gene)
BTKProtein695 (Entrez Gene)
RAF1Protein5894 (Entrez Gene)
RPS6KA1Protein6195 (Entrez Gene)
IL5RAProtein3568 (Entrez Gene)
GSK3AProtein2931 (Entrez Gene)
STAT3Protein6774 (Entrez Gene)
GSK3BProtein2932 (Entrez Gene)
FOXO3AProtein2309 (Entrez Gene)
SPRED1Protein161742 (Entrez Gene)
GRB2Protein2885 (Entrez Gene)
MAP2K2Protein5605 (Entrez Gene)
SYKProtein6850 (Entrez Gene)
SHC1Protein6464 (Entrez Gene)
MYCRna4609 (Entrez Gene)
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