Cholesterol Biosynthesis (Bos taurus)

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Description

Cholesterol is a waxy steroid metabolite found in the cell membranes and transported in the blood plasma of all animals. It is an essential structural component of mammalian cell membranes, where it is required to establish proper membrane permeability and fluidity. In addition, cholesterol is an important component for the manufacture of bile acids, steroid hormones, and several fat-soluble vitamins. Cholesterol is the principal sterol synthesized by animals, but small quantities are synthesized in other eukaryotes, such as plants and fungi. It is almost completely absent among prokaryotes, which include bacteria. Source: Wikipedia

Comments

HomologyConvert 
This pathway was inferred from Homo sapiens pathway WP197(78758) with a 100.0% conversion rate.

Quality Tags

Ontology Terms

 

Bibliography

No bibliography


History

View all...
CompareRevisionActionTimeUserComment
85039view07:05, 10 April 2016EgonwReverted to version '15:24, 30 June 2015' by Egonw
85038view03:21, 10 April 2016KhanspersQuick edit to datanode annotation or property
80735view15:24, 30 June 2015Mkutmonhomology conversion
71427view19:03, 17 October 2013MaintBotAutomated update of data sources
67110view10:07, 26 June 2013Christine ChichesterOntology Term : 'cholesterol biosynthetic pathway' added !
63450view17:14, 10 May 2013MaintBotUpdated to 2013 gpml schema
40584view19:33, 1 March 2011MaintBotRemoved redundant pathway information and comments
35152view14:22, 11 February 2010ThomasModified description
35151view14:21, 11 February 2010Thomasmoved literature from genmapp comments to bibliography
33822view00:25, 9 December 2009MaintBotAutomatic update of empty xrefs
31703view11:50, 14 August 2009MaintBotFixed group labels
30639view22:29, 29 July 2009MaintBotNew pathway

External references

Datanodes

View all...
NameTypeDatabase referenceComment
(S)-2,3-EpoxysqualeneMetabolite9029-62-3 (CAS)
7-DehydrocholesterolMetabolite434-16-2 (CAS)
Acetyl-CoAMetabolite72-89-9 (CAS)
CYP51A1GeneProductENSBTAG00000001992 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1595
CholesterolMetabolite57-88-5 (CAS)
DHCR7GeneProductENSBTAG00000016465 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1717
DimethylallylpyrophosphateMetabolite358-72-5 (CAS)
FDFT1GeneProductENSBTAG00000012432 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2222
FDPSGeneProductENSBTAG00000003948 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2224
Geranyl-PPMetabolite6699-20-3 (CAS)
HMG-CoAMetaboliteHMDB01375 (HMDB)
HMGCRGeneProductENSBTAG00000007840 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3156
HMGCS1GeneProductENSBTAG00000011839 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3157
IDI1GeneProductENSBTAG00000004075 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3422
LSSGeneProductENSBTAG00000018936 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:4047
LanosterinMetabolite79-63-0 (CAS)
LathosterolMetabolite80-99-9 (CAS)
MVDGeneProductENSBTAG00000012059 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:4597
MVKGeneProductENSBTAG00000005183 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:4598
Mevalonic acid 5-pyrophosphateMetabolite1492-08-6 (CAS)
Mevalonic acid-5PMetabolite73566-35-5 (CAS)
Mevalonic acidMetabolite150-97-0 (CAS)
NSDHLGeneProductENSBTAG00000009231 (Ensembl)
  • NAD(P) dependent steroid dehydrogenase-like
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:50814
PMVKGeneProductENSBTAG00000017819 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:10654
SC4MOLGeneProductENSBTAG00000003068 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6307
SC5DLGeneProductENSBTAG00000019246 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6309
SQLEGeneProductENSBTAG00000005498 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6713
SqualeneMetabolite111-02-4 (CAS)
farnesyl pyrophosphateMetabolite13058-04-3 (CAS)
isopentenyl pyrophosphateMetabolite358-71-4 (CAS)

Annotated Interactions

No annotated interactions
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