Cholesterol Biosynthesis (Homo sapiens)

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GenMAPP notes 
References: Bard, M., Bruner, D. A., Pierson, C. A., Lees, N. D., Biermann, B., Frye, L., Koegel, C., and Barbuch, R. (1996). Cloning and characterization of ERG25, the Saccharomyces cerevisiae gene encoding C-4 sterol methyl oxidase. Proc Natl Acad Sci U S A 93, 186-190.

Gaylor, J. L. (2002). Membrane-bound enzymes of cholesterol synthesis from lanosterol. Biochem Biophys Res Commun 292, 1139-1146.
Li, L., and Kaplan, J. (1996). Characterization of yeast methyl sterol oxidase (ERG25) and identification of a human homologue. J Biol Chem 271, 16927-16933.
Liu, X. Y., Dangel, A. W., Kelley, R. I., Zhao, W., Denny, P., Botcherby, M., Cattanach, B., Peters, J., Hunsicker, P. R., Mallon, A. M., et al. (1999). The gene mutated in bare patches and striated mice encodes a novel 3beta-hydroxysteroid dehydrogenase. Nat Genet 22, 182-187.
Ohashi, M., Mizushima, N., Kabeya, Y., and Yoshimori, T. (2003). Localization of mammalian NAD(P)H steroid dehydrogenase-like protein on lipid droplets. J Biol Chem 278, 36819-36829.
Sagami, H., Korenaga, T., and Ogura, K. (1993). Geranylgeranyl diphosphate synthase catalyzing the single condensation between isopentenyl diphosphate and farnesyl diphosphate. J Biochem (Tokyo) 114, 118-121.
Yoshida, Y., Noshiro, M., Aoyama, Y., Kawamoto, T., Horiuchi, T., and Gotoh, O. (1997). Structural and evolutionary studies on sterol 14-demethylase P450 (CYP51), the most conserved P450 monooxygenase: II. Evolutionary analysis of protein and gene structures. J Biochem (Tokyo) 122, 1122-1128.

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view11:30, 14 November 2008MaintBot[[Pathway:Homo sapiens:Cholesterol Biosynthesis]] moved to [[Pathway:WP197]]: Moved to stable identifier
view15:13, 22 May 2008Pahlesfor some metabolites the type was unknown
view13:51, 22 May 2008Pahlesreactions connected
view13:40, 22 May 2008PahlesPeriodical save, work in progress
view13:29, 22 May 2008Pahlesmetabolites added
view13:28, 22 May 2008PahlesPeriodical save, work in progress
view13:18, 22 May 2008PahlesPeriodical save, work in progress
view13:08, 22 May 2008PahlesPeriodical save, work in progress
view12:57, 22 May 2008PahlesPeriodical save, work in progress
view11:11, 17 May 2008MaintBotautomated metabolite conversion
view13:46, 7 January 2008MaintBot[[Pathway:Human:Cholesterol Biosynthesis]] moved to [[Pathway:Homo sapiens:Cholesterol Biosynthesis]]: Renaming species
view16:03, 18 December 2007MaintBotfixed category names
view12:42, 4 November 2007MaintBotAdded categories to GPML
view22:17, 22 May 2007N.Manteigpml file for [[Human:Cholesterol_Biosynthesis]]
view22:17, 22 May 2007M.Liebermangpml file for [[Human:Cholesterol_Biosynthesis]]

Pathway Info

DataNodes

View all 30 DataNodes

Name Type Backpage Header Database reference
FDPSGeneProductFDPS | farnesyl diphosphate synthase (farnesyl ...2224 (Entrez Gene)
Mevalonic acid 5-pyrophosphateMetabolite1492-08-6 (CAS)
IDI1GeneProductIDI1 | isopentenyl-diphosphate delta isomerase3422 (Entrez Gene)
CholesterolMetabolite57-88-5 (CAS)
HMGCS1GeneProductHMGCS1 | 3-hydroxy-3-methylglutaryl-Coenzyme A ...3157 (Entrez Gene)
7-DehydrocholesterolMetabolite434-16-2 (CAS)
HMGCRGeneProductHMGCR | 3-hydroxy-3-methylglutaryl-Coenzyme A r...3156 (Entrez Gene)
SqualeneMetabolite111-02-4 (CAS)
MVKGeneProductMVK | mevalonate kinase (mevalonic aciduria)4598 (Entrez Gene)
Mevalonic acidMetabolite150-97-0 (CAS)
MVDGeneProductMVD | mevalonate (diphospho) decarboxylase4597 (Entrez Gene)
Geranyl-PPMetabolite6699-20-3 (CAS)
FDFT1GeneProductFDFT1 | farnesyl-diphosphate farnesyltransferas...2222 (Entrez Gene)
(S)-2,3-EpoxysqualeneMetabolite9029-62-3 (CAS)
DHCR7GeneProductDHCR7 | 7-dehydrocholesterol reductase1717 (Entrez Gene)
Acetyl-CoAUnknown72-89-9 (CAS)
SC5DLGeneProductSC5DL | sterol-C5-desaturase (ERG3 delta-5-desa...6309 (Entrez Gene)
LathosterolMetabolite80-99-9 (CAS)
LSSGeneProductLSS | lanosterol synthase (23-oxidosqualene-la...4047 (Entrez Gene)
HMG-CoAMetabolite (CAS)
SQLEGeneProductSQLE | squalene epoxidase6713 (Entrez Gene)
Mevalonic acid-5PMetabolite73566-35-5 (CAS)
PMVKGeneProductPMVK | phosphomevalonate kinase10654 (Entrez Gene)
farnesyl pyrophosphateMetabolite13058-04-3 (CAS)
NSDHLGeneProductNSDHL | NAD(P) dependent steroid dehydrogenase-...50814 (Entrez Gene)
DimethylallylpyrophosphateMetabolite358-72-5 (CAS)
CYP51A1GeneProductCYP51A1 | cytochrome P450 family 51 subfamily...1595 (Entrez Gene)
LanosterinMetabolite79-63-0 (CAS)
SC4MOLGeneProductSC4MOL | sterol-C4-methyl oxidase-like6307 (Entrez Gene)
isopentenyl pyrophosphateMetabolite358-71-4 (CAS)
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