3, 5, 11, 15, 18171714, 17116714, 1714, 177114102-4, 6, 8...14, 17172-4, 6, 8...12-4, 6, 8...11114, 17162-4, 6, 8...11012-4, 6, 8...1172-4, 6, 8...2-4, 6, 8...171101ChromatinremodellingG2–MCheckpointBlocked replicationROSChange in the Cell conditionDNA repair and damage preventionAlkylating agentsCell-cycle progressionDNA damage sourceChromatin alterationReplication stressApoptosisBlocked transcriptionCell-cycleDifferent pathwayG2/M transitionDNA damage ATM dependentSenescenceDNA adductMetaboliteGene productEndogenous:Collapsed replication forksSingle stranded DNA replication breaksFree radicals (ROS)DNA repairROSG2/M checkpointActivationExogenous:Cigarette SmokeCaffeineRadiation (UV)ClastogenesHypoxiaGenotoxic drugsG1/S transitionSpecialized:Somatic hypermutaionV(D)J recombinationClass switchingInhibitionBulky DNA lesionDouble-strand breaksCaption:Cell survivalE2F1CCNB3CDKN1BRB1TLK1TP53AIP1BIDE2F1DDB2CASP8PMLCCND3CHEK1MRE11TNFRSF10BGADD45APRKDCATMPMAIP1RAD50RAD1CHEK2CDC25CCDK2GADD45ACCNB1c-MycCCND1ABL1CDK6CDC25ACCNE1FASPIDDAPAF1TP53CCNE2RRM2BATRGADD45GFANCD2CaffeineCASP9BAXCDKN1AGADD45BEstradiolGADD45GCCNB2RAD52ATRIPCCND2CYCSGADD45BNBNRAD9ACREBH2AFXCASP3SESN1HUS1RPA2SFNRAD51CDC2SMC1ARFCRB1TLK2CDK57-hydroxystaurosporineRAD17BBC3CDK4BRCA1