1-5SulfationSulfationMCF-7 cell proliferationMain pathwayDeaminationAlcohol metabolismAlternate pathwaySulfationCYP3A4SULT1E1CYP3A4cis-N-desmethyltamoxifen-O-glucuronideN,N-didesmethyltamoxifenUGT1A10alpha-hydroxytamoxifenCYP2D6CYP2C9CYP1A2CYP2C19CYP2D6FMO1alpha-hydroxy-N-desmethyltamoxifentrans-tamoxifenCYP2D6UGT2B7CYP3A5CYP3A5SULT2A1CYP2C19deamino-hydroxytamoxifenPAPStrans-4-Sulfoxytamoxifencis-4-hydroxytamoxifenCYP3A4CYP2C9CYP3A4MetaboliteSULT1A1Tamoxifen-N-oxideUGT1A8tamoxifen-N-glucuronidePAPCYP3A4FMO3PAPScis-tamoxifen-4-O-glucuronidetrans-4-hydroxytamoxifen-N-glucuronideCYP2C8UGT1A4trans-4-SulfoxytamoxifenN-desmethyltamoxifenCYP2E1CYP1B1CYP3A4trans-4-hydroxytamoxifenPAPSULT1E1cis-4-hydroxytamoxifen-N-glucuronidetrans-tamoxifen-4-O-glucuronideSULT2A1UGT1A4CYP2A6trans-N-desmethyltamoxifen-O-glucuronideSULT2A1SULT1A1UGT2B154-hydroxy-N-desmethyltamoxifencis-4-hydroxy-N-desmethyltamoxifenSSRICYP1A1CYP2C19CYP2D6CYP3A4UGT1A4