1-5MCF-7 cell proliferationDeaminationAlternate pathwayMain pathwayAlcohol metabolismSulfationSulfationSulfationtamoxifen-N-glucuronideSULT2A1SSRIUGT1A4deamino-hydroxytamoxifenSULT1E1Tamoxifen-N-oxideCYP3A4CYP2C19CYP2A6CYP3A4CYP1B1FMO3alpha-hydroxytamoxifen4-hydroxy-N-desmethyltamoxifenUGT1A8CYP3A4CYP3A5trans-4-SulfoxytamoxifenCYP2C9CYP2C9SULT1A1SULT1A1cis-4-hydroxy-N-desmethyltamoxifenCYP2E1CYP2C8CYP3A4SULT2A1SULT1E1FMO1UGT1A10cis-4-hydroxytamoxifenPAPSalpha-hydroxy-N-desmethyltamoxifenCYP1A1PAPtrans-tamoxifen-4-O-glucuronideUGT1A4CYP3A4cis-4-hydroxytamoxifen-N-glucuronidePAPCYP2D6CYP2D6UGT2B15trans-4-hydroxytamoxifenCYP3A4N-desmethyltamoxifenCYP3A4SULT2A1cis-tamoxifen-4-O-glucuronidetrans-N-desmethyltamoxifen-O-glucuronidePAPSUGT2B7CYP2C19cis-N-desmethyltamoxifen-O-glucuronidetrans-4-Sulfoxytamoxifentrans-4-hydroxytamoxifen-N-glucuronideCYP2D6UGT1A4N,N-didesmethyltamoxifenCYP1A2trans-tamoxifenCYP2D6MetaboliteCYP3A5CYP2C19