1Growth and MitogenesisStress Activated PathwaysGip38 MAPK PathwayNucleusActivatedRap1GAPGqGb and GgNRASMAP2K6RRASPLCB3GDPRapGAPIIMAP2K4RASA3HRASMAPK10MAPK3MAP3K12GTPMAP2K2ApoptosisMAP2K7MAP2K4KRASMBPMAP3K3MAPK14MAP3K1JUNELK1SIPA1MAP2RAF1MAP2K3MAPK1BRAFMAP2K1MAP3K2MAPK12ARAF