14118, 24611, 4213, 281331, 36, 372622139, 32, 423334, 156101461463352230, 40194, 1331, 36, 3725205, 1913, 2817, 1938, 431221440271056131110275, 191416, 18344, 41313403HepatocyteGlucose UptakeActivationInhibitionp70 S6 KinasesPancreatic Beta-cell proliferationLegendPI 3-Kinase isoformsErk SignalTransduction PathwayAmpk isoformsT3mTORC1Insulin Receptor SubstratesmTORInsulin Signaling Pathway PIK3CBSREBP PathwayPIK3CAPIK3CDProtein synthesis and Translation RegulationPIK3R4PIK3R1RPS6KB1SOS2PIK3CGGSSREBP2PI(3,4,5)P3PTPChrebpF-2,6-P2PIK3R3PIK3C2ARictorPIK3C2GCIP42TSC1Exo70RHEBIRS2GLUT4Autophagy SignalingSOS1GLUT1RAF1RPS6KB2INSRGCKLPLInsulinCD45+ hematopoietic- derived cell proliferation G-6-PRaptorRASTSC2amino acidsPIK3C3PEPCKIRS1 AMPKPathwayX-5-PCell GrowthDifferentiationGlucoseGlycolysis-Gluconeogenesismlst8PI(4,5)P2glycogenPIK3R2GlycogenesismTORPP2ALXRIRS4Triacylglyceride SynthesisGRB2PPARalphaSREBP1a-cFBPG6PCSIN1SEST3342544DIO2RXRATHRATHRBSLC16A2SLCO1C1T3T4RXRAANGPTL8T3 and T4 intracelullar uptakeSHC2SHC3SHC1GSK3AGSK3BPDKPKB/Akt isoformsAKT1AKT2pT308pT308EIF4EEIF4EBP1mlst8mTORSIN1pRictormlst8mTORC2FOXO1AFOXO3AmTORC2INSRCAP1CBLFLOT1FLOT2CRKRAPGEF1RHOQTransport of GLUT4 Transporters toPlasma MembraneRictorRXRA21, 35ABCG839FASN2ABCG5CYP3A439CYP7A12CYP2B622LXR target genes7Drug and steroidmetabolismMulti-drugresistancelipogenesisSCDTranscriptionfactorsMEK/MAP Kinasesp90 Rsk KinasesMAP2K1MAP3K7MAPK14MAPK1MAP2K2RPS6KA5MAP3K2MAP3K6MAPK8MAP4K1MAP3K11MAP4K3MAPK10RPS6KA6MAP2K7MAP3K4MAP3K1MAP3K12MAPK4RPS6KA4MAPK11MAP4K5MAPK6MAP4K4MAPK3MAP3K14MAPK12MAP2K5MAP2K4MAPK13RPS6KA1RPS6KA2MAP3K5RPS6KA3MAPK9MAPK7MAP3K3MAP3K9MAP3K8MAP2K6MAP3K13MAP4K2MAP2K3MAP3K10MINK1PI(3,4,5)P3PKB/Akt isoformsAKT1pS473pT308AKT2pT308pS473CBLCCBLBFOXO1AFOXO3AInsulinINSRLXR target genes7CatalysisInsulin Signaling Pathway Undefined MechanismT4Activation from within the PathwayAMPKy3AMPKa1AMPKy2AMPKy1AMPKb2AMPKb1AMPKa2Ampk isoforms1616, 18