1Receptor-mediated NP uptakeIntegrinAutocrine loopNP-induced extracellular ROS productionFibronectinEGFRHRASCollagenαAmphiregulinApoptosisROSNRASKRASRAFMAP2K1MAP2K2MAPK1JNK1JNK2JNK3MAPK12MAPK13MAPK14MAPK11βTalinPaxillinSrcFAKSosGrbPI3KAKTProliferationInflammationMigrationAngiogenesisDifferentiationROSEndocytosis of NP