1LysosomeLipid peroxidationLowered pHMitochondriaDNA damageNECROSOMEIronGe NPRIPK1CalciumJNKTRIFlipoxygenasePARP1ATPTNFR1TRADDNec-1Arachidonic acidFADDcPLA2ROSPAMPsSMasesCalpainsGlutaminolysisNecroptosisTNFCeramideCASP82RIPK3TLRsFerritinLabile iron poolGlycogenolysisGlycolysisIron