MAPK9PSMAD3PMAPK3PSMAD3PSTAT5BPIKBKBPAGERPNeuriteAGE/RAGE Signaling PathwayCalcification of smooth muscle cellsAGERPCDC42GTPRAC1GTPGgRHOAGTPCASP3IRS1PRKCAMYD88PIRAK4MSNPTIRAPROCK1PHRASSRCGTPPMAPK1PFOXO1SP1dePNFKB1RELAPPAKT1dePPMAPK14MAPK8PPFOXO4JAK2STAT1PPSTAT3CHUKPCASP8PNFKBIAUbPNFKB1RELAPPSMAD2PSMAD2PTubular epithelium myofibroblast transitionDIAPH1PLCPLA2G4APNa+ K+ ATPaseNeutrophilRearrangement of the actin cytoskeletonAutophagy in vascular smooth muscle cellsDissolution of gap junctions in human hepatoma cellsCell proliferationATF2JUNPPFibroblastsCASP9Retinal pericytesOsteoblastsINS-1 cellsNONeuroblastoma cellsIncrease in monolayer permeabilityRenal cellular hypertrophyMitogeneis in NRK-49F cellsMAP2K1PRAF1PALPLMonocyte adhesion to retinal endothelial cellsNCF1PSTAT5APSP1NOXApoptosis inFOXO1FOXO4Osteogenicdifferentiationof VSMCsRenal proximal tubular cellsNOS2NOS3Endothelial cellDegradationDissociationH2O2MitochondrialPRKCBPRKCZProteinDissociation of PPIReceptorProteinTransportLeads toInduced catalysisProtein-protein interaction (PPI)LEGENDPhosphorylationNucleusCytoplasmCYNUEnzymeEnzyme complex or specific component unknownCYNUCYNUCYNUCYNUCYNUCYNUCMLCELAGE-modified albuminPentosidineLigandSmall moleculesEnzymeProteins activated (identified by assays)MTMitochondriaCYMTApoptosis inPodocytesFibroblastsCYCSCYCSSOD1burstTGF-betaindependentDephosphorylationInhibition of proliferation and migration ofbone marrow mesenchymal stem cellsT-cellsEndothelial cell permeabilityPIP2DAGCa2+Arachidonic acidROSoutgrowthpermeabilitytransitiondysfunctionsGlyc-FBSPhosphorylated stateUbUbiquitinated stateGgGeranylgeranylated statedePDephosphrylated stateRegulation ofcytoskeletonCML-CollagenFormation of F-actin stress fibersSHC1PEGFRPDDOSTInternalizationAGE removalandAGEsMSR1AGEsINSINSRHIF1AHIF1ACYNUInhibition oftubulogenesis ofproximal tubule cellsEZRdePPPlacenta andgestational membranesProstaglandin F2alphaProstaglandin E2Released fromChondrocytesLGALS3AGEsincreasedPRKCDPInhibition ofMicroglial cellsMMP2MMP14MMP13MMP9MMP7