ROSCa2+Cytochrome CArachidonic acidNUCytochrome CApoptosisTNF alpha Signaling PathwayNUCYCeramidePLA2ROSProcaspase 3/7CYHydroperoxidesNecrosisNFKBIESELEAPAF1OTUD7BKSR1CASP7BIRC2BAXJUNRFKTNFRELACSNK2A1PPP2CANOXO1RFFLMAP2K7BTRCSOS1RAF1BCL2L1DIABLONOX1CREBBPNFKB2MAPK8MAP2K4TBK1RELBIDPro-CASP8CDC37NFKB1TNFRSF1ATNFAIP3TRAF2BIRC3MAP3K8TNFRSF1ATNFRSF1BTAB1TNFCASP3MAPK9RIPK3CUL1MAPK1SKP1BIRC2MAPK9NFKB2TNFMAP2K3MAP2K6DIABLOBADPLK1TNFTAB2MAP3K7NFKB1BIRC3MAP4K2MAP3K1TRADDRIPK1TRADDRAC1MAP3K5PYGLCYBAFBXW11TXNPRKCZTRAP1IKBKGCASP8TNFMAP3K3TNFRSF1BRIPK1KSR2NSMAFTNFRSF1BMADDCFLARGLUL IL6AKT1IKBKBFADDTRAF2CHUKRELNFKBIBHSP90AA1CCL2GRB2TAB3SMPD2PSMD2NFKBIATNFBCL2L1TANKMAPK3TNFRSF1ARELACASP9TRAF1RASMAP3K14MAPK8PPPPPPPPPCPPPUbUbPPNUCYCYMTCYMTProteinReceptorProteinProteinmRNASmall moleculeLigandInduced activationEnzyme complexInhibitionAuto catalysisTransportPositive regulation of gene expressionLeads to through unknown mechanismNegative regulation of gene expressionTranslocation UbiquitinationDeubiquitinationSumoylationInduced catalysisProtein-protein interactionAcetylationDephosphorylationLEGENDPhosphorylationDeacetylationGolgi apparatusEndosomeNucleusMitochondrionDesumoylationMethylationDemethylationPalmitoylationCytoplasmECPlasma membraneMTEndoplasmic reticulumCYPMGONUExtracellularERENProteolytic cleavageMoleculeProtein-protein dissociation