ERNucleus4434361, 4113COPII coated vesicleLipogenic enzymesGolgi 40Positive effectLegendNegative effectUp regulation CleavageCatalysisCholesterol effluxTranscription-TranslationInhibitionCofactorCholesterol synthesisstimulationSREExact mechanism unknownAKTHMGCRRBP4FGF21PKAUFAsCDK8importin betaInsulinmiRNA33bmiRNA33aPUFAsNFYCAMPSCAPSIRT1PI3KSREBP2gp78ATF6nSREBPAMPKCholesterolS1PGlutamineGlucoseINSIG1LXRLPIN1GSK3TRC8mTORC1Oxysterols312, 196SCAP2291757, 163712152510188911, 42353321, 38243923, 26, 4520SCAPINSIG2INSIG1INSIG2SREBP1a,-c3, 27SREBP2SREBP1a,-cSREBP2SREBP1a,-cSAR1ASCAPSREBP2SREBP1a,-cSAR1BSAR1ASAR1BSEC23ASEC23BSEC24ASEC24BSEC24CSEC24DSEC13SEC31ASEC31BSEC13SEC23ASEC23BSEC24ASEC24BSEC24CSEC24DSAR1ASCAPSREBF2SREBP1a,-cSAR1BSEC31ASEC31BS2P29SCAPSREBP2SREBP1a,-cnSREBP1a,-cGeneSREnSREBP2GeneCholesterogenic enzymesLipoprotein metabolismCholesterol uptakeCofactorCREBSP132NFYCREBSP1YY114, 30YY1PGC-1beta4ARC105ARC10528LSSHMGCSMVDIDIFDPSFDFTSQLECYP51A1LPLLDLRSCARB1ACACAGPAFASNDBIACLYMDHPPARGACSSCDFatty aciddegradationFatty acid synthesisSIRT143INSIG1INSIG2SREBP2SREBP1a,-c