5, 111318, 144, 123, 57, 102, 6platelet dense tubular network lumencytosolDiacylglycerollipasePRKCD Fatty AcidTRPC6 TRPC7 H2OProtein kinase C,novel isoforms:DAGADPDAG MGLLITPR1 DAG-activatedTRPC3/6/7DiacylglycerolkinaseDAG ITPR3 ATP2AG1,2-diacyl-glycerol3-phosphateProtein kinase C,novel isoformsPRKCQ AAITPR2 Ca2+DAG RASGRP1 Ca2+ Ca2+ PRKCE IP3Rtetramer:I(1,4,5)P3:4xCa2+TRPC3/6/7DAGRASGRP2 CalDAG-GEFsIP3R tetramerITPR3 CalDAG-GEFs:DAG:Ca2+H+PRKCH Ca2+I(1,4,5)P3ITPR2 I(1,4,5)P3 TRPC3(1-848) GlycerolITPR1 9