21DNAApoptotic factors"Amplification loop"Modulation of apoptosisApoptosomeTRAFsPIDDosomeDNA-FragmentationActivation of Caspases- extrinsic pathwayMitochondriaJNKCa2+MIR29B1C-IAP2IL1R1AP-1IKB-alphaDAXXsurvivinBFL-1CASP2APAF1BOKIKKBimBAXTOLLIPOsteoprotegerinIL1R2MADDc-FLIPAIFM1TRADDFasLTRAF6CASP3TRADDCASP4NIKDR3ERKMYD88CASP6TNFR-2CASP2CRADDARTSCASP9CASP1p16-INK4BLKBAG3HSPA1APIDDApollonBIKCyto CAsk1BADBcl-WAP-1BIDTP53CASP7JNKTNFR-1HRKPRKD1c-FLIPHumaninNAIPXIAPCalpainAIFM2TNFR-1IL1R1MCL1BMFDR3DcR3Bit1RIPK1FAP-1TRAIL-R1ENDOGCASP2TRAILBAK1HTRA2/OmiDFFABNIP3SurvivinPEA15CASP10c-fosBcl-BFADDDFFBFASCASP8TRAIL-R4BCL2CASP8Smac/DIABLOIRAK1IG20Nf-kBTRAIL-R2RIPK1BCL-XLTNFR-1TRAF3Bcl-XsC-IAP1TRADDLivinFASPumaTRAIL-R3NoxaThe interactions of this pathway were computationally validated. See reference.DISCActivation of Caspases- intrinsic pathwayMIR29B2