Based on Intracellular Signaling Pathways Regulating Pluripotency of Embryonic Stem Cells, Okita et al, Current Stem Cell Research and Therapy, 2006, 1, 103-111 Cellular Process The cytokine LIF and its downstream effector STAT3 are essential for maintenance of pluripotency in mouse ES cells. The requirement for the transcription factor Oct3/4 for ES cell pluripotency is also well-documented. However, LIF is not involved in self-renewal of human ES cells, suggesting that other pathways must play an important role in this process. The importance of other signal transduction pathways, including BMP and Wnt signalings, as well as novel transcription factors such as Nanog, is now being recognized. Source: Intracellular Signaling Pathways Regulating Pluripotency of Embryonic Stem Cells, Okita et al, Current Stem Cell Research and Therapy, 2006, 1, 103-111 a79 Also known as Compound C Type your comment here e8b d82 a1a

15867910 PubMed Transient inhibition of BMP signaling by Noggin induces cardiomyocyte differentiation of mouse embryonic stem cells. Nat Biotechnol 2005 Yuasa S Itabashi Y Koshimizu U Tanaka T Sugimura K Kinoshita M Hattori F Fukami S Shimazaki T Ogawa S Okano H Fukuda K 18220859 PubMed Intracellular signaling pathways regulating pluripotency of embryonic stem cells. Curr Stem Cell Res Ther 2006 Okita K Yamanaka S 11602624 PubMed Role of AMP-activated protein kinase in mechanism of metformin action. J Clin Invest 2001 Zhou G Myers R Li Y Chen Y Shen X Fenyk-Melody J Wu M Ventre J Doebber T Fujii N Musi N Hirshman MF Goodyear LJ Moller DE 18682835 PubMed Dorsomorphin, a selective small molecule inhibitor of BMP signaling, promotes cardiomyogenesis in embryonic stem cells. PLoS ONE 2008 Hao J Daleo MA Murphy CK Yu PB Ho JN Hu J Peterson RT Hatzopoulos AK Hong CC