Physiological ProcessThe core of this pathway was elucidated over a century ago and involves the conversion of angiotensinogen to angiotensin I (Ang I) by renin, its subsequent conversion to angiotensin II (Ang II) by angiotensin converting enzyme. Ang II activates the angiotensin II receptor type 1 to induce aldosterone synthesis, increasing water and salt resorption and potassium excretion in the kidney and increasing blood pressure.
Source: PharmGKB (http://www.pharmgkb.org/do/serve?objId=PA2023&objCls=Pathway)This pathway was inferred from Homo sapiens pathway [http://wikipathways.org/instance/WP554_r77712 WP554(77712)] with a 90.0% conversion rate.b93HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:624HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5972HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1585ce3HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1511HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:185ce3HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:183HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:186bc9HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1636bd1HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:4142c74HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:7040af8HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1215HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1636HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3827HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:4306ce3b5dHomologyConvert: Homo sapiens to Bos taurus: Original ID = L:623HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:4846HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:10159c16HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:59272c74HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1636HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:59272bc9bc915174896PubMedPharmacogenetics of antihypertensive drug responses.Am J Pharmacogenomics2004Schwartz GLTurner STangiotensin signaling pathwayPW:0000245Pathway Ontology16374430PubMedRenin increases mesangial cell transforming growth factor-beta1 and matrix proteins through receptor-mediated, angiotensin II-independent mechanisms.Kidney Int2006Huang YWongamorntham SKasting JMcQuillan DOwens RTYu LNoble NABorder W17464936PubMedThe emerging role of ACE2 in physiology and disease.J Pathol2007Hamming ICooper MEHaagmans BLHooper NMKorstanje ROsterhaus ADTimens WTurner AJNavis Gvan Goor H18417113PubMedThe (pro)renin receptor: a new addition to the renin-angiotensin system?Eur J Pharmacol2008Batenburg WWJan Danser AH18729003PubMedMineralocorticoid receptor antagonists and endothelial function.Curr Opin Investig Drugs2008Maron BALeopold JAACE inhibitor drug pathwayPW:0001228Pathway Ontology15134803PubMedThe regulation of aldosterone synthase expression.Mol Cell Endocrinol2004Bassett MHWhite PCRainey WE17376010PubMedAngiotensin II reactivation and aldosterone escape phenomena in renin-angiotensin-aldosterone system blockade: is oral renin inhibition the solution?Expert Opin Pharmacother2007Athyros VGMikhailidis DPKakafika AITziomalos KKaragiannis A18449520PubMedAre we poised to target ACE2 for the next generation of antihypertensives?J Mol Med2008Ferreira AJRaizada MK16679330PubMedSystematic review and meta-analysis of ethnic differences in risks of adverse reactions to drugs used in cardiovascular medicine.BMJ2006McDowell SEColeman JJFerner RE18035185PubMedEffects of renin-angiotensin system inhibition on end-organ protection: can we do better?Clin Ther2007Weir MR