Mitochondrial fatty acid synthesis and respiration (WP4318)

Homo sapiens

Open in new tab
Download PNG Download SVG Download JSON Download GPML Learn more about Downloads
"The dynamics of mitochondrial fission and fusion. The localization, as well as some interaction and modification of the principal proteins involved in the two processes are shown. Once dephosphorylated, DRP1 is recruited to the outer membrane by FIS1 or by another, unknown, component. The oligomerization of DRP1 is followed by constriction of the membrane and mitochondrial fission. The pro-fusion proteins (MFNs on the outer membrane and OPA1 on the inner membrane) oligomerize to induce fusion of the membranes. Other additional components of the machinery are shown. BAX, BCL2-associated X protein; BNIP3, BCL2/E1B 19 kDa-interacting protein 3; CAMK1a, calcium/calmodulin-dependent protein kinase 1a; DRP1, dynamin-related protein 1; FIS1, fission protein 1; GDAP1, ganglioside-induced differentiation-associated protein 1; l-OPA1, long form of OPA1; MFN, mitofusin; MIB, mitofusin-binding protein; MTP18, mitochondrial protein 18 kDa; OPA1, optic atrophy 1; PKA, protein kinase A; PLD, phospholipase D; s‑OPA1: short form of OPA1." Luca Scorrano et al 2010

Authors

Amadeo , Kristina Hanspers , Susan Coort , and Ash Iyer

Activity

last edited

Discuss this pathway

Check for ongoing discussions or start your own.

Cited In

Are you planning to include this pathway in your next publication? See How to Cite and add a link here to your paper once it's online.

Organisms

Homo sapiens

Communities

Annotations

Pathway Ontology

mitochondria fusion pathway mitochondria fission pathway

Participants
Query Drugst.One

Label Type Compact URI Comment
MIB1 GeneProduct ensembl:ENSG00000101752
MFN1 GeneProduct ensembl:ENSG00000171109
FIS1 GeneProduct ensembl:ENSG00000214253
MFN2 GeneProduct ensembl:ENSG00000116688
OPA1 GeneProduct ensembl:ENSG00000198836
BNIP3 GeneProduct ensembl:ENSG00000176171
MFN1 GeneProduct ensembl:ENSG00000171109
MFN2 GeneProduct ensembl:ENSG00000116688
BNIP3 GeneProduct ensembl:ENSG00000176171
DRP1 GeneProduct ensembl:ENSG00000087470
DRP1 GeneProduct ensembl:ENSG00000087470
FIS1 GeneProduct ensembl:ENSG00000214253
BAX GeneProduct ensembl:ENSG00000087088
BCL2 GeneProduct ensembl:ENSG00000171552
Endophilin-A1 GeneProduct ensembl:ENSG00000107295
PLD1 GeneProduct ensembl:ENSG00000075651
MTP18 GeneProduct ensembl:ENSG00000242114
OPA1 GeneProduct ensembl:ENSG00000198836
Prohibitin Protein uniprot:A8K401

References

  1. Mitochondrial fatty acid synthesis type II: more than just fatty acids. Hiltunen JK, Schonauer MS, Autio KJ, Mittelmeier TM, Kastaniotis AJ, Dieckmann CL. J Biol Chem. 2009 Apr 3;284(14):9011–5. PubMed Europe PMC Scholia
  2. Mitochondrial fatty acid synthesis and respiration. Hiltunen JK, Autio KJ, Schonauer MS, Kursu VAS, Dieckmann CL, Kastaniotis AJ. Biochim Biophys Acta. 2010;1797(6–7):1195–202. PubMed Europe PMC Scholia